Pathophysiology Final Detailed Exam
Questions and Verified Solutions 2026
The human body requires cholesterol. It is used to construct:
a. muscle fibers
b. proteins
c. DNA
d. the cell membrane - Correct Answer-correct answer: d. the cell membrane
Cholesterol is used by the cell to construct the phospholipid bilayer of the cell
membrane. Every cell in the body.
Mitochondria contain the enzymes necessary for:
a. gluconeogenesis
b. phagocytosis
c. photosynthesis
d. ATP production - Correct Answer-correct answer: d. ATP production
Mitochondria are the powerhouses of the cell. Their main function is to produce ATP.
The movement of ions through the sodium-potassium pump is an example of ________.
a. osmosis
b. active transport
c. simple diffusion
d. passive transport - Correct Answer-correct answer: b. active transport
The sodium-potassium pump is an example of an active transport pump. Active
transport requires an energy input; in this case, ATP.
In the resting membrane potential, potassium is predominantly an ________-cellular ion
and sodium is predominantly an ________-cellular ion.
a. extra-; intra-
b. intra-; intra-
c. intra-; extra-
d. extra-; extra- - Correct Answer-correct answer: c. intra-; extra-
Sodium in predominantly an extracellular ion, with a normal serum concentration of 135-
145 mEq/L and intracellular concentration of 3.5-5 mEq/L. Potassium is largely an
intracellular ion, at concentrations of 135-145 mEq/L intracellularly and extracellular
concentration of 3.5-5 mEq/L.
Pathophysiology
,Pathophysiology
During the action potential of a muscle or nerve cells, sodium rushing into the cell
causes an ________ response. - Correct Answer-correct answer: all or none
An all-or-none response occurs after sodium influx, which results in the subsequent
phases of the action potential. Once sodium influxes into the cell, conduction cannot be
stopped.
Hypertension, or high blood pressure, requires the heart to become stronger. The cell's
adaption strategy in response to hypertension is ________.
a. atrophy
b. hypertrophy
c. metaplasia
d. dysplasia - Correct Answer-correct answer: b. hypertrophy
Hypertrophy is the equivalent of body builders getting huge from lifting weights.
Gangrene is an example of:
a. hyperplasia
b. apoptosis
c. necrosis
d. cellular aging - Correct Answer-correct answer: c. necrosis
An individual who carries a copy of the gene is a carrier. A synonym for carrier, in this
case, is ________.
a. recessive
b. dominant
c. heterozygous
d. homozygous - Correct Answer-correct answer: c. heterozygous
Huntington's disease is an autosomal dominant genetic disorder. One strange and cruel
feature of Huntington's disease is that patients usually have had children by the time
symptoms emerge. What is the likelihood that children of parents—each homozygous
(i.e. HH and HH)—will inherit the disease?
a. 25%
b. 75%
c. 50%
d. 100% - Correct Answer-correct answer: d. 100%
Since Huntington's disease follows an autosomal dominant inheritance pattern, any
dominant allele (i.e. "big H") that is passed on will result in the disease. In the case of
two homozygous parents, 100% of the offspring will have the disease.
What is epigenetics? - Correct Answer-Epigenetics is the study of changes in organisms
caused by modification of gene expression rather than alteration of the genetic code
itself.
Pathophysiology
, Pathophysiology
Antigen-presenting cells function to:
a. initiate the complement cascade by way of the alternate pathway
b. stimulate cytokine production by macrophages
c. phagocytose and degrade foreign antigens
d. display foreign antigen on their cell surfaces bound to MHC - Correct Answer-correct
answer: d. display foreign antigen on their cell surfaces bound to MHC
Which clinical finding is most indicative of an acute bacterial infection?
a. increased (band) neutrophils
b. elevated erythrocyte sedimentation rate
c. elevated WBC count
d. elevated temperature - Correct Answer-correct answer: a. increased (band)
neutrophils
Remember that initially in the stress response (release of cortisol) WBCs are released
from their moorings along the vessel walls. It takes time for more WBCs to be produced
in the bone marrow and the first WBCs to be released are immature "teenagers" who
haven't yet matured into fully functional neutrophils. THAT's the indication that there's
an active infection. We call it a "left shift;" a shift to less mature cells in response to
active infection.
Interleukin-1, interleukin-6, and tumor necrosis factor-α are inflammatory cytokines
secreted by:
a. lymphocytes
b. plasma cells
c. neutrophils
d. macrophages - Correct Answer-correct answer: d. macrophages
Immunity to a specific organism can be determined by a lab test to check the ________.
a. erythrocyte sedimentation rate
b. WBC count
c. antibody titer
d. active phase protein count - Correct Answer-correct answer: c. antibody titer
The primary function of B cells is:
a. killing antigen-presenting cells
b. making (i.e. synthesizing) antibodies
c. secreting cytokines
d. killing virally infected cells - Correct Answer-correct answer: b. making (i.e.
synthesizing) antibodies
B cells = antibodies
Dramatic hypotension sometimes accompanies type I hypersensitivity reactions
because:
Pathophysiology