Pharmacology Final Exam - Multiple
Choice Questions and well defined
answers
The bactericidal antibiotic that interferes with bacterial cell-wall synthesis and that may cause "red man
syndrome" if injected too rapidly is
A. piperacillin
B. vancomycin
C. gentamicin
D. clindamycin
E. cephalexin - CORRECT ANSWERS-B. vancomycin
The main pharmacokinetic feature of aminoglycosides is that they are
A. lipid soluble
B. well absorbed orally
C. poorly absorbed from the GI tract and excreted mostly unchanged in the urine if injected
D. devoid of serious adverse effects
E. undergo extensive metabolism - CORRECT ANSWERS-C. poorly absorbed from the GI tract and
excreted mostly unchanged in the urine if injected
Which of the following is NOT correct about antifungal drugs or fungal infection?
A. systemic infection may occur in patients who are receiving drugs to suppress their immune system
B. warts are an example of a dermatophytic fungal infection
C. the majority of antifungal drugs interfere with fungal cell-wall integrity
D. amphotericin B is associated with serious renal toxicity
E. topical antifungal drugs are available OTC - CORRECT ANSWERS-B. warts are an example of a
dermatophytic fungal infection
,Which antifungal drug is matched with its correct mechanism of action?
A. echinocandins inhibit polysaccharide (glucan) synthesis in the cell wall
B. flucytosine binds to the cell membrane
C. ticonazole is an antimetabolite for fungal RNA
D. amphotericin B binds to a cytochrome P450-dependent enzyme
E. ketoconazole inhibits proteases in the host cell nuclei - CORRECT ANSWERS-A. echinocandins inhibit
polysaccharide (glucan) synthesis in the cell wall
Which of the following is correct about viruses?
A. active infection is the only way to develop immunity to the microorganism
B. viruses attach to the keratin protein and remain dormant for years
C. viruses can quickly develop resistance to drugs
D. viruses die as soon as they land on hard surfaces
E. respiratory viral infections are treated with acyclovir - CORRECT ANSWERS-C. viruses can quickly
develop resistance to drugs
Which drug is effective against systemic viral infections?
A. griseofulvin
B. butenafine
C. gentian violet
D. clotrimazole
E. enfuvirtide - CORRECT ANSWERS-E. enfuvirtide
the mechanisms of action for antiviral medications include
A. changing cell-wall synthesis
,B. binding to ergosterol
C. inhibiting cell mitosis
D. inhibiting neuraminidase
E. facilitating viral fusion to the host cell - CORRECT ANSWERS-D. inhibiting neuraminidase
Which of the following is NOT true of the treatment for viral infections?
A. they are difficult to treat due to host cell invasion
B. immunity can be gained through the attenuated live virus
C. treatment can be given via an intranasal spray
D. the vaccines are contraindicated in people allergic to eggs
E. effective treatment occurs only with respiratory drug administration - CORRECT ANSWERS-E. effective
treatment occurs only with respiratory drug administration
The antimetabolite that blocks DNA synthesis by interfering with folic acid is
A. mercaptopurine
B. fluorouracil
C. methotrexate
D. cytarabine
E. tamoxifen - CORRECT ANSWERS-C. methotrexate
The drug that binds to mitotic tubules to cause metaphase arrest is
A. doxorubicin
B. asparaginase
C. etoposide
D. vincristine
E. mercaptopurine - CORRECT ANSWERS-D. vincristine
, The monoclonal antibody that inhibits vascular endothelial growth factor (VEGF) and new blood vessel
formation is
A. imatinib
B. trastuzumab
C. bevacizumab
D. gefitinib
E. cetuximab - CORRECT ANSWERS-C. bevacizumab
Which of the following is true of chemotherapy?
A. one of the early goals of chemotherapy is remission
B. antineoplastic drugs only attack cancerous cells
C. drug resistance is increased with combination therapy
D. it is the primary form of treatment for solid tumors
E. it is usually effective after one treatment - CORRECT ANSWERS-A. one of the early goals of
chemotherapy is remission
Select the correct statements for alkylating drugs.
A. bind irreversibly with nucleic acids
B. decrease cells' ability to synthesize proteins
C. are cell-cycle nonspecific
D. bind irreversibly with nucleic acids
E. all statements are true - CORRECT ANSWERS-E. all statements are true
The mechanisms of actions for the antimetabolites include
A. preventing DNA replication
Choice Questions and well defined
answers
The bactericidal antibiotic that interferes with bacterial cell-wall synthesis and that may cause "red man
syndrome" if injected too rapidly is
A. piperacillin
B. vancomycin
C. gentamicin
D. clindamycin
E. cephalexin - CORRECT ANSWERS-B. vancomycin
The main pharmacokinetic feature of aminoglycosides is that they are
A. lipid soluble
B. well absorbed orally
C. poorly absorbed from the GI tract and excreted mostly unchanged in the urine if injected
D. devoid of serious adverse effects
E. undergo extensive metabolism - CORRECT ANSWERS-C. poorly absorbed from the GI tract and
excreted mostly unchanged in the urine if injected
Which of the following is NOT correct about antifungal drugs or fungal infection?
A. systemic infection may occur in patients who are receiving drugs to suppress their immune system
B. warts are an example of a dermatophytic fungal infection
C. the majority of antifungal drugs interfere with fungal cell-wall integrity
D. amphotericin B is associated with serious renal toxicity
E. topical antifungal drugs are available OTC - CORRECT ANSWERS-B. warts are an example of a
dermatophytic fungal infection
,Which antifungal drug is matched with its correct mechanism of action?
A. echinocandins inhibit polysaccharide (glucan) synthesis in the cell wall
B. flucytosine binds to the cell membrane
C. ticonazole is an antimetabolite for fungal RNA
D. amphotericin B binds to a cytochrome P450-dependent enzyme
E. ketoconazole inhibits proteases in the host cell nuclei - CORRECT ANSWERS-A. echinocandins inhibit
polysaccharide (glucan) synthesis in the cell wall
Which of the following is correct about viruses?
A. active infection is the only way to develop immunity to the microorganism
B. viruses attach to the keratin protein and remain dormant for years
C. viruses can quickly develop resistance to drugs
D. viruses die as soon as they land on hard surfaces
E. respiratory viral infections are treated with acyclovir - CORRECT ANSWERS-C. viruses can quickly
develop resistance to drugs
Which drug is effective against systemic viral infections?
A. griseofulvin
B. butenafine
C. gentian violet
D. clotrimazole
E. enfuvirtide - CORRECT ANSWERS-E. enfuvirtide
the mechanisms of action for antiviral medications include
A. changing cell-wall synthesis
,B. binding to ergosterol
C. inhibiting cell mitosis
D. inhibiting neuraminidase
E. facilitating viral fusion to the host cell - CORRECT ANSWERS-D. inhibiting neuraminidase
Which of the following is NOT true of the treatment for viral infections?
A. they are difficult to treat due to host cell invasion
B. immunity can be gained through the attenuated live virus
C. treatment can be given via an intranasal spray
D. the vaccines are contraindicated in people allergic to eggs
E. effective treatment occurs only with respiratory drug administration - CORRECT ANSWERS-E. effective
treatment occurs only with respiratory drug administration
The antimetabolite that blocks DNA synthesis by interfering with folic acid is
A. mercaptopurine
B. fluorouracil
C. methotrexate
D. cytarabine
E. tamoxifen - CORRECT ANSWERS-C. methotrexate
The drug that binds to mitotic tubules to cause metaphase arrest is
A. doxorubicin
B. asparaginase
C. etoposide
D. vincristine
E. mercaptopurine - CORRECT ANSWERS-D. vincristine
, The monoclonal antibody that inhibits vascular endothelial growth factor (VEGF) and new blood vessel
formation is
A. imatinib
B. trastuzumab
C. bevacizumab
D. gefitinib
E. cetuximab - CORRECT ANSWERS-C. bevacizumab
Which of the following is true of chemotherapy?
A. one of the early goals of chemotherapy is remission
B. antineoplastic drugs only attack cancerous cells
C. drug resistance is increased with combination therapy
D. it is the primary form of treatment for solid tumors
E. it is usually effective after one treatment - CORRECT ANSWERS-A. one of the early goals of
chemotherapy is remission
Select the correct statements for alkylating drugs.
A. bind irreversibly with nucleic acids
B. decrease cells' ability to synthesize proteins
C. are cell-cycle nonspecific
D. bind irreversibly with nucleic acids
E. all statements are true - CORRECT ANSWERS-E. all statements are true
The mechanisms of actions for the antimetabolites include
A. preventing DNA replication
