PCB 3233 EXAM 5 UCF FAll 2015 LATEST UPDATE
Memory cells; plasma cells - ANSWER Centroycytes can be activated to become
what?
Plasma Cells - ANSWER _____ can differentiate directly from: Activated B-cells ,
memory cells (or memory B cells), or Isotype switched, somatically
hypermutated centrocytes.
CR2 - ANSWER Binds to complement deposited on the pathogen by way of iC3b
and C3d derivatives of the C3b fragments
CD19 - ANSWER Signaling chain of the B-cell co-receptor
CD81 - ANSWER Protein that binds to CD19 and is essential in bringing it to the
B-cell surface
CR2;CD81(TAPA-1);CD19 - ANSWER What are the 3 protein components of the
B-cell co-receptor?
Factor I - ANSWER CR1 on B-cell that binds to C3b and becomes susceptible to
cleavage by what?
iC3b;C4d; complement receptor 1 (CR1) - ANSWER Factor I first gives what
fragment? followed by what fragment that is more stable? This process enables
what to increase ligand abundance for the B-cell co-receptor on the pathogens
surface?
C3d; Lyn ; CD19 - ANSWER CR2 binds to what nearby fragment? This brings the
B-cell receptor and co-receptor into juxtaposition setting the stage for the
tyrosine kinase what? This is bound to Igα, to phosphorylate the cytoplasmic tail
of what?
B-cell receptor - ANSWER Phosphorylated CD19 binds to intracellular signaling
molecules that synergizes with those coming from the ___________
1,000-10,000 - ANSWER Simultaneous ligation of the B-cell receptor and co-
receptor increases overall signal ______ fold greatly increasing the B-cell's
sensitivity to antigen.
infecting pathogen - ANSWER Antibodies recruit "destructive, nonspecific"
immune system components to the what?
, destroy the pathogen - ANSWER Antibodies bind and link the pathogen to
effector molecules or cells that will do what?
NO! Additional signals are required to "activate" a mature naïve B cell -
ANSWER Is X-linking of the BCR by Ag sufficient to activate a mature naïve B
cell?
Thymus independent antigens - ANSWER What does TI mean?
Thymus dependent antigens - ANSWER What does TD mean?
DiGeorges syndrome - ANSWER Infants with ______________ have no thymus
therefore lack T-cells to help activate TD (Thymus Dependent) B-cells.
thymus transplant - ANSWER In DiGeorge syndrome , Infants will die in early
childhood unless given ________________
cross-linking - ANSWER B cell activation requires __ of B cell receptors by
antigen, which results in clustering
helper CD4 T cells - ANSWER TD antigens activate B cells in the secondary
lymphoid tissue where B cells, specific antigen and helper ____ are brought
together
TI-1 - ANSWER Bind to BCR and other receptors on B cells, and induces the B
cell to proliferate and differentiate (example LPS binding to TLR)
TI-2 - ANSWER Bind to repetitive Antigens and cause extensive cross-linking of
BCR's that no additional signal is needed to activate B-1 cell (override CD14 for
help) an example is cell-wall polysaccharides of streptococcus pneumoniae
LBP; LPS; LPS - ANSWER TI-1 antigen uses _____ ( a soluble LPS binding protein
) binds to BCR after its formed a _____ complex and other receptor on B-cells,
such as ____ binding to CD14/TLR
B cells; CD4 T cells - ANSWER TD antigens activate ______ in secondary
lymphoid tissues; where specific antigens and _____ are brought together
pathogens surface; IgM - ANSWER TI-2 provide repetitive carbohydrates or
protein epitopes at a high density on a ____________. The major Isotype secreted
is ____________.
TI-1; TI-2 - ANSWER Two types of TI antigens are what?
Memory cells; plasma cells - ANSWER Centroycytes can be activated to become
what?
Plasma Cells - ANSWER _____ can differentiate directly from: Activated B-cells ,
memory cells (or memory B cells), or Isotype switched, somatically
hypermutated centrocytes.
CR2 - ANSWER Binds to complement deposited on the pathogen by way of iC3b
and C3d derivatives of the C3b fragments
CD19 - ANSWER Signaling chain of the B-cell co-receptor
CD81 - ANSWER Protein that binds to CD19 and is essential in bringing it to the
B-cell surface
CR2;CD81(TAPA-1);CD19 - ANSWER What are the 3 protein components of the
B-cell co-receptor?
Factor I - ANSWER CR1 on B-cell that binds to C3b and becomes susceptible to
cleavage by what?
iC3b;C4d; complement receptor 1 (CR1) - ANSWER Factor I first gives what
fragment? followed by what fragment that is more stable? This process enables
what to increase ligand abundance for the B-cell co-receptor on the pathogens
surface?
C3d; Lyn ; CD19 - ANSWER CR2 binds to what nearby fragment? This brings the
B-cell receptor and co-receptor into juxtaposition setting the stage for the
tyrosine kinase what? This is bound to Igα, to phosphorylate the cytoplasmic tail
of what?
B-cell receptor - ANSWER Phosphorylated CD19 binds to intracellular signaling
molecules that synergizes with those coming from the ___________
1,000-10,000 - ANSWER Simultaneous ligation of the B-cell receptor and co-
receptor increases overall signal ______ fold greatly increasing the B-cell's
sensitivity to antigen.
infecting pathogen - ANSWER Antibodies recruit "destructive, nonspecific"
immune system components to the what?
, destroy the pathogen - ANSWER Antibodies bind and link the pathogen to
effector molecules or cells that will do what?
NO! Additional signals are required to "activate" a mature naïve B cell -
ANSWER Is X-linking of the BCR by Ag sufficient to activate a mature naïve B
cell?
Thymus independent antigens - ANSWER What does TI mean?
Thymus dependent antigens - ANSWER What does TD mean?
DiGeorges syndrome - ANSWER Infants with ______________ have no thymus
therefore lack T-cells to help activate TD (Thymus Dependent) B-cells.
thymus transplant - ANSWER In DiGeorge syndrome , Infants will die in early
childhood unless given ________________
cross-linking - ANSWER B cell activation requires __ of B cell receptors by
antigen, which results in clustering
helper CD4 T cells - ANSWER TD antigens activate B cells in the secondary
lymphoid tissue where B cells, specific antigen and helper ____ are brought
together
TI-1 - ANSWER Bind to BCR and other receptors on B cells, and induces the B
cell to proliferate and differentiate (example LPS binding to TLR)
TI-2 - ANSWER Bind to repetitive Antigens and cause extensive cross-linking of
BCR's that no additional signal is needed to activate B-1 cell (override CD14 for
help) an example is cell-wall polysaccharides of streptococcus pneumoniae
LBP; LPS; LPS - ANSWER TI-1 antigen uses _____ ( a soluble LPS binding protein
) binds to BCR after its formed a _____ complex and other receptor on B-cells,
such as ____ binding to CD14/TLR
B cells; CD4 T cells - ANSWER TD antigens activate ______ in secondary
lymphoid tissues; where specific antigens and _____ are brought together
pathogens surface; IgM - ANSWER TI-2 provide repetitive carbohydrates or
protein epitopes at a high density on a ____________. The major Isotype secreted
is ____________.
TI-1; TI-2 - ANSWER Two types of TI antigens are what?
