TEST BANK
Stevens's Clinical Immunology: A Laboratory Perspective
Linda E. Miller
6th Edition
,Table of Contents
Chapter 01 Introduction to Immunity and the Immune System 1
Chapter 02 Innate Immunity 8
Chapter 03 Antibody Structure and Function 18
Chapter 04 Nature of Antigens and the Major Histocompatibility Complex 33
Chapter 05 Adaptive Immunity 47
Chapter 06 Cytokines 58
Chapter 07 The Complement System 69
Chapter 08 Safety and Quality Management 78
Chapter 09 Principles of Serological Testing 89
Chapter 10 Precipitation and Agglutination Reactions 99
Chapter 11 Labeled Immunoassays 110
Chapter 12 Molecular Diagnostic Techniques 122
Chapter 13 Flow Cytometry and Laboratory Automation 133
Chapter 14 Hypersensitivity 148
Chapter 15 Autoimmune Diseases 160
Chapter 16 Transplantation Immunology 173
Chapter 17 Tumor Immunology 182
Chapter 18 Immunoproliferative Diseases 192
Chapter 19 Immunodeficiency Diseases and Inborn Errors of Immunity 202
Chapter 20 Laboratory Detection of Bacterial Infections 213
Chapter 21 Spirochete Diseases 225
Chapter 22 Laboratory Diagnosis of Parasitic and Fungal Infections 240
Chapter 23 Serological and Molecular Detection of Viral Infections 251
Chapter 24 Laboratory Diagnosis of Human Retroviruses 267
Chapter 25 Immunization and Vaccines 280
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
Chapter 1 Introduction to Immunity and the Immune System
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. Attenuation can take place through ______ a pathogen.
A. freezing
B. growing
C. aging
D. flooding
ANS: C
PTS: 1
OBJ: 1
MSC: Taxonomy 1
2. The scientist known for his use of attenuated vaccines and as the father of immunology is:
A. Edward Jenner.
B. Elie Metchnikoff.
C. Louis Pasteur.
D. Emil von Behring.
ANS: C
PTS: 1
OBJ: 2
MSC: Taxonomy 1
3. The field of immunology can be credited for its contributions to the development of:
A. bacterial identification.
B. vaccines.
C. surgery.
D. phlebotomy.
ANS: B
PTS: 1
OBJ: 2
MSC: Taxonomy 1
4. The ancient practice of inhaling powder from smallpox scabs is an early version of:
A. innate immunity.
B. vaccination.
C. susceptibility.
D. cell identification.
ANS: B
PTS: 1
OBJ: 2
MSC: Taxonomy 2
______________________________________________________________________________________________
1|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
5. Humoral immunity was considered the most important aspect of immunity for a time in history
because of the work of _____________, who received the Nobel Prize in Physiology for his
work in serum therapy.
A. Louis Pasteur
B. Emil von Behring
C. Almroth Wright
D. Edward Jenner
ANS: B
PTS: 1
OBJ: 3
MSC: Taxonomy 1
6. The discovery of _______ helped bring the importance of cellular immunity to light.
A. antibodies
B. phagocytosis
C. opsonins
D. bacterial toxin neutralization by serum
ANS: B
PTS: 1
OBJ: 3
MSC: Taxonomy 2
7. Phagocytosis is appropriately categorized into which of the following?
A. Adaptive immunity
B. Innate immunity
C. Humoral immunity
D. Specific immunity
ANS: B
PTS: 1
OBJ: 3
MSC: Taxonomy 2
8. Maturation and differentiation of important immune cells happen within the:
A. blood.
B. bone marrow.
C. lymph nodes.
D. spleen.
ANS: B
PTS: 1
OBJ: 4
MSC: Taxonomy 1
9. Which of the following cells can phagocytize foreign microbes?
A. T lymphocytes
______________________________________________________________________________________________
2|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
B. B lymphocytes
C. Macrophages
D. Natural killer (NK) cells
ANS: C
PTS: 1
OBJ: 5
MSC: Taxonomy 1
10. Which of the following cells is a phagocytic cell that has a similar morphology to nerve cells?
A. Neutrophils
B. Dendritic cells
C. Mast cells
D. Macrophages
ANS: B
PTS: 1
OBJ: 5 & 6
MSC: Taxonomy 1
11. Macrophages play a key role in adaptive immunity through which function?
A. Phagocytosis
B. Anti-tumor activity
C. Presenting phagocytosed microbes to T lymphocytes
D. Microbial killing
ANS: C
PTS: 1
OBJ: 6
MSC: Taxonomy 2
12. Which granulocytic cell, most known for its role in allergic reactions, contains serine proteases,
heparin, and histamine?
A. Basophil
B. Macrophage
C. Eosinophil
D. Mast cell
ANS: D
PTS: 1
OBJ: 6
MSC: Taxonomy 1
13. A patient with a weakened immune response may need to have which primary lymphoid tissue
examined?
A. Spleen
B. Mucosal-associated lymphoid tissue (MALT)
C. Thymus
______________________________________________________________________________________________
3|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
D. Lymph nodes
ANS: C
PTS: 1
OBJ: 7 & 8
MSC: Taxonomy 3
14. Lymphocytes come in contact with foreign antigens and activate the adaptive immune system in
which lymphoid tissue?
A. Bone marrow
B. Peripheral blood
C. Thymus
D. Skin-associated lymphoid tissue (SALT)
ANS: D
PTS: 1
OBJ: 7 & 8
MSC: Taxonomy 3
15. Which lymphoid tissue can protect us against pathogens we eat?
A. Mucosal-associated lymphoid tissue (MALT)
B. Skin-associated lymphoid tissue (SALT)
C. Lymph nodes
D. Spleen
ANS: A
PTS: 1
OBJ: 8
MSC: Taxonomy 3
16. Secondary lymphoid tissues that are located throughout the human body and serve as a collecting
duct for lymph fluid are:
A. spleen cells.
B. lymph nodes.
C. mucosal-associated lymphoid tissue (MALT).
D. skin-associated lymphoid tissue (SALT).
ANS: B
PTS: 1
OBJ: 8 & 9
MSC: Taxonomy 1
17. Foreign microbes that enter through a cut in our hand should expect defense from which lym-
phoid tissue?
A. Skin-associated lymphoid tissue (SALT)
B. Spleen
C. Mucosal-associated lymphoid tissue (MALT)
D. Thymus
ANS: A
______________________________________________________________________________________________
4|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
PTS: 1
OBJ: 8
MSC: Taxonomy 3
18. Macrophages line the _______ found within the lymph nodes.
A. outer cortex
B. inner medulla
C. paracortex
D. sinuses
ANS: D
PTS: 1
OBJ: 9
MSC: Taxonomy 1
19. B cells activate and generate B-cell memory in the _____ of the lymph nodes.
A. sinuses
B. secondary follicles
C. paracortex
D. primary follicles
ANS: B
PTS: 1
OBJ: 9
MSC: Taxonomy 2
20. Antigen presentation by dendritic cells to T cells happens within the ______of the lymph nodes.
A. primary follicles
B. secondary follicles
C. paracortex
D. sinuses
ANS: C
PTS: 1
OBJ: 9
MSC: Taxonomy 2
21. We can identify lymphocyte populations by proteins found on their cell surfaces. These are
known as:
A. adhesion molecules.
B. antibodies.
C. chemotaxins.
D. clusters of differentiation.
ANS: D
PTS: 1
OBJ: 10
MSC: Taxonomy 1
______________________________________________________________________________________________
5|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
22. Which CD marker is found on B lymphocytes?
A. CD4
B. CD20
C. CD8
D. CD3
ANS: B
PTS: 1
OBJ: 10
MSC: Taxonomy 1
23. A patient with a viral infection that has stimulated their cell-mediated immunity might have an
increased number of which type of leukocytes in their peripheral blood?
A. Lymphocytes
B. Neutrophils
C. Monocytes
D. Basophils
ANS: A
PTS: 1
OBJ: 11
MSC: Taxonomy 3
24. A patient with antibodies in their serum to a particular virus has activated which immune cells?
A. Natural killer (NK) cells
B. Macrophages
C. B lymphocytes
D. T lymphocytes
ANS: C
PTS: 1
OBJ: 11
MSC: Taxonomy 3
25. Humoral immunity is a key function of which cell?
A. Natural killer (NK) cells
B. T lymphocytes
C. Macrophages
D. B lymphocytes
ANS: D
PTS: 1
OBJ: 11
MSC: Taxonomy 2
26. Which lymphocyte is part of our innate immunity?
A. CD4 cells
B. CD8 cells
______________________________________________________________________________________________
6|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
C. CD19 cells
D. Natural killer (NK) cells
ANS: D
PTS: 1
OBJ: 10, 11
MSC: Taxonomy 2
27. Our first line of defense against virally infected cells and tumor cells are:
A. B lymphocytes.
B. T lymphocytes.
C. neutrophils.
D. Natural killer (NK) cells.
ANS: D
PTS: 1
OBJ: 11
MSC: Taxonomy 1
______________________________________________________________________________________________
7|Page
, ______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
Chapter 2 Innate Immunity
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. Which of the following innate immune mechanisms is not part of the anatomical barriers that
keep microorganisms from entering the body?
A. Keratin coating epithelial cells
B. Lactic acid in sweat
C. Surfactant in mucosal secretions
D. Phagocytosis
ANS: D
PTS: 1
OBJ: 1 & 3
MSC: Taxonomy 1
2. A pathogen killed by defensins was defeated by which of the following defense mechanisms?
A. Specialized barriers, adaptive immunity
B. Specialized barriers, innate immunity
C. Cell receptors, adaptive immunity
D. Cell receptors, innate immunity
ANS: B
PTS: 1
OBJ: 1 & 2
MSC: Taxonomy 3
3. Which best describes the process of a neutrophil recognizing zymosan and engulfing a pathogen?
A. An adaptive immune response to a gram-negative bacterial invasion
B. An innate immune response to a yeast invasion
C. An innate immune response to a gram-negative bacterial invasion
D. An adaptive immune response to a gram-positive bacterial invasion
ANS: B
PTS: 1
OBJ: 2 & 7
MSC: Taxonomy 3
______________________________________________________________________________________________
8|Page
Stevens's Clinical Immunology: A Laboratory Perspective
Linda E. Miller
6th Edition
,Table of Contents
Chapter 01 Introduction to Immunity and the Immune System 1
Chapter 02 Innate Immunity 8
Chapter 03 Antibody Structure and Function 18
Chapter 04 Nature of Antigens and the Major Histocompatibility Complex 33
Chapter 05 Adaptive Immunity 47
Chapter 06 Cytokines 58
Chapter 07 The Complement System 69
Chapter 08 Safety and Quality Management 78
Chapter 09 Principles of Serological Testing 89
Chapter 10 Precipitation and Agglutination Reactions 99
Chapter 11 Labeled Immunoassays 110
Chapter 12 Molecular Diagnostic Techniques 122
Chapter 13 Flow Cytometry and Laboratory Automation 133
Chapter 14 Hypersensitivity 148
Chapter 15 Autoimmune Diseases 160
Chapter 16 Transplantation Immunology 173
Chapter 17 Tumor Immunology 182
Chapter 18 Immunoproliferative Diseases 192
Chapter 19 Immunodeficiency Diseases and Inborn Errors of Immunity 202
Chapter 20 Laboratory Detection of Bacterial Infections 213
Chapter 21 Spirochete Diseases 225
Chapter 22 Laboratory Diagnosis of Parasitic and Fungal Infections 240
Chapter 23 Serological and Molecular Detection of Viral Infections 251
Chapter 24 Laboratory Diagnosis of Human Retroviruses 267
Chapter 25 Immunization and Vaccines 280
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
Chapter 1 Introduction to Immunity and the Immune System
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. Attenuation can take place through ______ a pathogen.
A. freezing
B. growing
C. aging
D. flooding
ANS: C
PTS: 1
OBJ: 1
MSC: Taxonomy 1
2. The scientist known for his use of attenuated vaccines and as the father of immunology is:
A. Edward Jenner.
B. Elie Metchnikoff.
C. Louis Pasteur.
D. Emil von Behring.
ANS: C
PTS: 1
OBJ: 2
MSC: Taxonomy 1
3. The field of immunology can be credited for its contributions to the development of:
A. bacterial identification.
B. vaccines.
C. surgery.
D. phlebotomy.
ANS: B
PTS: 1
OBJ: 2
MSC: Taxonomy 1
4. The ancient practice of inhaling powder from smallpox scabs is an early version of:
A. innate immunity.
B. vaccination.
C. susceptibility.
D. cell identification.
ANS: B
PTS: 1
OBJ: 2
MSC: Taxonomy 2
______________________________________________________________________________________________
1|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
5. Humoral immunity was considered the most important aspect of immunity for a time in history
because of the work of _____________, who received the Nobel Prize in Physiology for his
work in serum therapy.
A. Louis Pasteur
B. Emil von Behring
C. Almroth Wright
D. Edward Jenner
ANS: B
PTS: 1
OBJ: 3
MSC: Taxonomy 1
6. The discovery of _______ helped bring the importance of cellular immunity to light.
A. antibodies
B. phagocytosis
C. opsonins
D. bacterial toxin neutralization by serum
ANS: B
PTS: 1
OBJ: 3
MSC: Taxonomy 2
7. Phagocytosis is appropriately categorized into which of the following?
A. Adaptive immunity
B. Innate immunity
C. Humoral immunity
D. Specific immunity
ANS: B
PTS: 1
OBJ: 3
MSC: Taxonomy 2
8. Maturation and differentiation of important immune cells happen within the:
A. blood.
B. bone marrow.
C. lymph nodes.
D. spleen.
ANS: B
PTS: 1
OBJ: 4
MSC: Taxonomy 1
9. Which of the following cells can phagocytize foreign microbes?
A. T lymphocytes
______________________________________________________________________________________________
2|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
B. B lymphocytes
C. Macrophages
D. Natural killer (NK) cells
ANS: C
PTS: 1
OBJ: 5
MSC: Taxonomy 1
10. Which of the following cells is a phagocytic cell that has a similar morphology to nerve cells?
A. Neutrophils
B. Dendritic cells
C. Mast cells
D. Macrophages
ANS: B
PTS: 1
OBJ: 5 & 6
MSC: Taxonomy 1
11. Macrophages play a key role in adaptive immunity through which function?
A. Phagocytosis
B. Anti-tumor activity
C. Presenting phagocytosed microbes to T lymphocytes
D. Microbial killing
ANS: C
PTS: 1
OBJ: 6
MSC: Taxonomy 2
12. Which granulocytic cell, most known for its role in allergic reactions, contains serine proteases,
heparin, and histamine?
A. Basophil
B. Macrophage
C. Eosinophil
D. Mast cell
ANS: D
PTS: 1
OBJ: 6
MSC: Taxonomy 1
13. A patient with a weakened immune response may need to have which primary lymphoid tissue
examined?
A. Spleen
B. Mucosal-associated lymphoid tissue (MALT)
C. Thymus
______________________________________________________________________________________________
3|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
D. Lymph nodes
ANS: C
PTS: 1
OBJ: 7 & 8
MSC: Taxonomy 3
14. Lymphocytes come in contact with foreign antigens and activate the adaptive immune system in
which lymphoid tissue?
A. Bone marrow
B. Peripheral blood
C. Thymus
D. Skin-associated lymphoid tissue (SALT)
ANS: D
PTS: 1
OBJ: 7 & 8
MSC: Taxonomy 3
15. Which lymphoid tissue can protect us against pathogens we eat?
A. Mucosal-associated lymphoid tissue (MALT)
B. Skin-associated lymphoid tissue (SALT)
C. Lymph nodes
D. Spleen
ANS: A
PTS: 1
OBJ: 8
MSC: Taxonomy 3
16. Secondary lymphoid tissues that are located throughout the human body and serve as a collecting
duct for lymph fluid are:
A. spleen cells.
B. lymph nodes.
C. mucosal-associated lymphoid tissue (MALT).
D. skin-associated lymphoid tissue (SALT).
ANS: B
PTS: 1
OBJ: 8 & 9
MSC: Taxonomy 1
17. Foreign microbes that enter through a cut in our hand should expect defense from which lym-
phoid tissue?
A. Skin-associated lymphoid tissue (SALT)
B. Spleen
C. Mucosal-associated lymphoid tissue (MALT)
D. Thymus
ANS: A
______________________________________________________________________________________________
4|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
PTS: 1
OBJ: 8
MSC: Taxonomy 3
18. Macrophages line the _______ found within the lymph nodes.
A. outer cortex
B. inner medulla
C. paracortex
D. sinuses
ANS: D
PTS: 1
OBJ: 9
MSC: Taxonomy 1
19. B cells activate and generate B-cell memory in the _____ of the lymph nodes.
A. sinuses
B. secondary follicles
C. paracortex
D. primary follicles
ANS: B
PTS: 1
OBJ: 9
MSC: Taxonomy 2
20. Antigen presentation by dendritic cells to T cells happens within the ______of the lymph nodes.
A. primary follicles
B. secondary follicles
C. paracortex
D. sinuses
ANS: C
PTS: 1
OBJ: 9
MSC: Taxonomy 2
21. We can identify lymphocyte populations by proteins found on their cell surfaces. These are
known as:
A. adhesion molecules.
B. antibodies.
C. chemotaxins.
D. clusters of differentiation.
ANS: D
PTS: 1
OBJ: 10
MSC: Taxonomy 1
______________________________________________________________________________________________
5|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
22. Which CD marker is found on B lymphocytes?
A. CD4
B. CD20
C. CD8
D. CD3
ANS: B
PTS: 1
OBJ: 10
MSC: Taxonomy 1
23. A patient with a viral infection that has stimulated their cell-mediated immunity might have an
increased number of which type of leukocytes in their peripheral blood?
A. Lymphocytes
B. Neutrophils
C. Monocytes
D. Basophils
ANS: A
PTS: 1
OBJ: 11
MSC: Taxonomy 3
24. A patient with antibodies in their serum to a particular virus has activated which immune cells?
A. Natural killer (NK) cells
B. Macrophages
C. B lymphocytes
D. T lymphocytes
ANS: C
PTS: 1
OBJ: 11
MSC: Taxonomy 3
25. Humoral immunity is a key function of which cell?
A. Natural killer (NK) cells
B. T lymphocytes
C. Macrophages
D. B lymphocytes
ANS: D
PTS: 1
OBJ: 11
MSC: Taxonomy 2
26. Which lymphocyte is part of our innate immunity?
A. CD4 cells
B. CD8 cells
______________________________________________________________________________________________
6|Page
,______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
C. CD19 cells
D. Natural killer (NK) cells
ANS: D
PTS: 1
OBJ: 10, 11
MSC: Taxonomy 2
27. Our first line of defense against virally infected cells and tumor cells are:
A. B lymphocytes.
B. T lymphocytes.
C. neutrophils.
D. Natural killer (NK) cells.
ANS: D
PTS: 1
OBJ: 11
MSC: Taxonomy 1
______________________________________________________________________________________________
7|Page
, ______________________________________________________________________________________________
Test Bank - Stevens's Clinical Immunology: A Laboratory Perspective, 6th Edition (Miller, 2026)
Chapter 2 Innate Immunity
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. Which of the following innate immune mechanisms is not part of the anatomical barriers that
keep microorganisms from entering the body?
A. Keratin coating epithelial cells
B. Lactic acid in sweat
C. Surfactant in mucosal secretions
D. Phagocytosis
ANS: D
PTS: 1
OBJ: 1 & 3
MSC: Taxonomy 1
2. A pathogen killed by defensins was defeated by which of the following defense mechanisms?
A. Specialized barriers, adaptive immunity
B. Specialized barriers, innate immunity
C. Cell receptors, adaptive immunity
D. Cell receptors, innate immunity
ANS: B
PTS: 1
OBJ: 1 & 2
MSC: Taxonomy 3
3. Which best describes the process of a neutrophil recognizing zymosan and engulfing a pathogen?
A. An adaptive immune response to a gram-negative bacterial invasion
B. An innate immune response to a yeast invasion
C. An innate immune response to a gram-negative bacterial invasion
D. An adaptive immune response to a gram-positive bacterial invasion
ANS: B
PTS: 1
OBJ: 2 & 7
MSC: Taxonomy 3
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8|Page
