Systems Path Exam #2: CNS Questions and Answers Updated 2026

Systems Path Exam #2: CNS
Questions and Answers Updated
2026
AM7-
YOMchildMdevelopsMheadaches,Mvomiting,MandMaMstaggeringMgait.MAMcerebellarMneoplas
mMisMdiagnosed.MTheMneoplasmMisMMOSTMlikelyMa(n):

A.MEpendymoma

B.MGlioblastomaMmultiforme

C.MMedulloblastoma

D.MNeuroblastoma

E.MOligodendrogliomaM-MAnswerMC.MMedulloblastoma



TheMcauseMofMimmediateMdeathMfollowingMaMhighMvelocityMbulletMwoundMtoMtheMhea
d.M

A.MCerebralMhemorrhage

B.MBrainMherniationsMdueMtoMexpansionMofMpropellantMgases

C.MDeathMofMneurons

D.MInflammationMofMbrainMsubstances

E.MBlockMofMCSFMcirculationM-
MAnswerMB.MBrainMherniationsMdueMtoMexpansionMofMpropellantMgases



AM45-
YOMmaleMhasMbeenMhealthyMallMofMhisMlifeMuntilMtheMrecentMonsetMofMheadaches.MA
McerebralMangiogramMdemonstratesMaM7-
mmMsaccularManeurysmMatMtheMtrifurcationMofMtheMrightMmiddleMcerebralMartery.MWhic
hMofMtheMfollowingMeventsMisMmostMlikelyMtoMresultMfromMthisMlesion?

A.MEpiduralMhematoma

B.MSubarachnoidMhemorrhage

C.MSubduralMhematoma

D.MCerebellarMtonsillarMherniationM

E.MHydrocephalusM-MAnswerMB.MSubarachnoidMhemorrhage

,TheMtumorMofMtheMCNSMthatMisMfoundMmostMcommonlyMinMtheM4thMventricleMinside
MtheMskullMorMinMtheMcentralMcanalMofMtheMspinalMcord.M

A.MAstrocytoma

B.MOligodendroglioma

C.MMedulloblastoma

D.MEpendymoma

E.MMeningiomaM-MAnswerMD.MEpendymoma



AsMstatedMinMclass,MtheMmostMcommonMfactorMassociatedMwithMtheMetiologyMofMepile
psyMisMwhat?

A.MNeoplasms

B.MIdiopathic

C.MHeadMinjury

D.MMetabolicMdiseaseMofMsomeMtype

E.MInfectionM(meningitis)M-MAnswerMB.MIdiopathic



AnMautosomalMrecessiveMdisorderMthatMisMlethalMinMinfancyMorMearlyMchildhood,MandMi
sMcharacterizedMbyMtheMaccumulationMofMaMgangliosideMwithinMtheMneuronsMofMtheMC
NS.MRetinalMinvolvementMproducesMaMcherry-redMspotMonMtheMmacula.M

A.MTay-Sach'sMdisease

B.MGaucher'sMdisease

C.MALDM(Adrenoleukodystrophy)

D.MMLDM(MetachromaticMleukodystrophy)

E.MWilson'sMdiseaseM-MAnswerMA.MTay-Sach'sMdisease



TheMeffectsMofMbluntMtraumaMcausingMbrainMdamageMonMtheMoppositeMsideMofMtheMb
rainMtoMtheMsiteMofMinjury.M

A.MCoupMinjury

B.MContreMcoupMinjury

C.MConvertingMcoupMinjury

D.MConcussion

E.MComaM-MAnswerMB.MContreMcoupMinjury

,WhichMofMtheMfollowingMisMtheMtypeMofMSpinaMbifidaMthatMisMmostMcommonlyMassoci
atedMwithMseriousMneurologicalMdefects?

A.MSpinaMbifidaMocculta

B.MMeningocele

C.MMyelomeningocele

D.MAnencephalyM-MAnswerMC.MMyelomeningocele



TheMviralMencephalitisMthatMisMseenMinMpatientsMwhoMhaveMAIDS,MbutMisMactuallyMdue
MtoMinfectionMwithMaMpapovavirus

A.MProgressiveMmultifocalMleukoencephalopathy

B.MRabies

C.MCMV

D.MHerpesMsimplex

E.MSubacuteMsclerosingMpanencephalitisM-
MAnswerMA.MProgressiveMmultifocalMleukoencephalopathy



Wernicke'sMKorsakoff'sMsyndrome,MwhichMusuallyMincludesMamnesia,Mconfabulation,MandM
generalMmentalMdeterioration,MisMtypicallyMassociatedMwithMwhichMofMtheMfollowing?

A.MAlcoholism

B.MPerniciousManemia

C.MThiamineMdeficiency

D.MAOTA

E.MOnlyMAMandMCM-MAnswerME.MOnlyMAMandMC



TheMdiseaseMofMtheMCNSMthatMbeginsMwithMdegenerationMofMtheManteriorMhornMcells,
MusuallyMinMtheMlumbosacralMregion,MandMprogressesMbyMaMretrogradeMdegenerationMt
oMaffectMtheMcellsMofMtheMpyramidalMsystem.MThisMproducesMprogressiveMweaknessMan
dMdeath.M

A.MAlzheimer's

B.MAmyotrophicMlateralMsclerosis

C.MHuntington'sMChorea

D.MParkinson'sMdisease

E.MFriedreich'sMataxiaM-MAnswerMB.MAmyotrophicMlateralMsclerosis

, ThisMisManMinheritedMdiseaseMthatMmanifestsMafterMtheMageMofM30-
40MandMleadsMtoMdeathMwithinM10MyearsMofMonset.M

A.MAlzheimer's

B.MAmyotrophicMlateralMsclerosis

C.MHuntington'sMChorea

D.MParkinson'sMdisease

E.MFriedreich'sMataxiaM-MAnswerMHuntington'sMChorea



ThisMisMaMdegenerativeMdiseaseMthatMproducesMaMprogressiveMdementiaMwithMtheMhisto
logicalMpictureMofMneurofibrillaryMtangles,MsenileMplaques,MandMamyloidMinfiltrationMofMb
loodMvessels.M

A.MAlzheimer's

B.MAmyotrophicMlateralMsclerosis

C.MHuntington'sMChorea

D.MParkinson'sMdisease

E.MFriedreich'sMataxiaM-MAnswerMA.MAlzheimer's



ThisMisMaMdiseaseMproducedMbyMdegenerationMofMtheMsubstantialMnigraMthatMleadsMto
MlackMofMdopamineMinMtheMbasalMganglia.M

A.MAlzheimer's

B.MAmyotrophicMlateralMsclerosis

C.MHuntington'sMChorea

D.MParkinson'sMdisease

E.MFriedreich'sMataxiaM-MAnswerMD.MParkinson'sMdisease



AMfrequentMcauseMofMcerebralMembolismMinMtheMdaysMfollowingMaMmyocardialMinfarctio
n.M

A.MDeepMvenousMthrombosis

B.MCarotidMatherosclerosis

C.MVertebralMarteryMatherosclerosisM

D.MMuralMclotMinMleftMventricleM-MAnswerMD.MMuralMclotMinMleftMventricle