f3 f3 f3 f3 f3 f3
Answers Latest 2026 Complete Exam
f3 f3 f3 f3 f3
(Usmle Step 1)Newest Updates
f3 f3 f3 f3
1. 70yo M dies in a motor vehicle collision. Was undergoing evaluation
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
for occult blood in the stool. Photo of transverse colon shown. Dx? -
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
SOLUTION - Tubular adenoma or villous polyp. GI blood loss
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
suggests a risk for malignancy
f3 f3 f3 f3 f3
2. 38yo M truck driver with 1-week hx of watery, itchy eyes and a runny
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
nose. Physical shows inflamed nasal mucosa. No congestion in
f3 f3 f3 f3 f3 f3 f3 f3 f3
lower lung. Pharmacotherapy? - SOLUTION - Loratadine--> less
f3 f3 f3 f3 f3 f3 f3 f3
sedating antihistamine
f3 f3
3. 16yo girl with 3-day hx of fever, nonproductive cough, and fatigue. T
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
38.3, P 88/min, BP 102-70. PE shows pale conjunctivae. CXR shows
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
bilateral interstitial infiltrates. Blood spontaenously agglutinates
f3 f3 f3 f3 f3 f3
while awaiting transport to the laboratory. Antibody isotypes causing
f3 f3 f3 f3 f3 f3 f3 f3 f3
agglutination? - SOLUTION - IgM (mono and mycoplasma)
f3 f3 f3 f3 f3 f3 f3 f3
4. 24yo M with small tender blisters on his penis 3 days after
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
unprotected sex. Photograph shown. Causal agent? - SOLUTION -
f3 f3 f3 f3 f3 f3 f3 f3 f3
HSV-2
f3
5. 42yo F with 3-year hx of an intermittent facial rash, including the
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
forehead, eyelids, nose, and cheeks. Rash seems to be getting worse
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
since she moved from New York to Florida last year. Spicy foods
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
precipitate a flushing reaction that seems to exacerbate the rash. PE
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
shows erythema over the nose and cheeks, with scattered
f3 f3 f3 f3 f3 f3 f3 f3 f3
telangiectasias and a few papules. Dx? - SOLUTION - Rosacea
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Page 1 of 37 f3f4 f3f4 f3f4
,6. 53yo M returned from Africa, has fever, headache, and abdominal
f3 f3 f3 f3 f3 f3 f3 f3 f3
discomfort. Received appropriate vaccinations prior to the trip. T
f3 f3 f3 f3 f3 f3 f3 f3 f3
39.4C. A wright-stained peripheral smear shown (ring forms in
f3 f3 f3 f3 f3 f3 f3 f3 f3
RBCs). Dx? - SOLUTION - Malaria
f3 f3 f3 f3 f3 f3
7. 68yo F with T2DM and hypertension that has been poorly controlled
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
despite hydrochlorothiazide treatment. BP 150/96, Labs show serum
f3 f3 f3 f3 f3 f3 f3 f3
glucose concentration of 130 and proteinuria. In addition to current
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Rx, which is most appropriate pharmacotherapy? - SOLUTION - ACE I
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
(Lisinopril)
f3
8. 66yo M with stage IV colon cancer with 3-day hx of severe diarrhea
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
after receiving chemotherapy with flourouracil, leucovorin, and
f3 f3 f3 f3 f3 f3 f3
irinotecan. Prescribed opioid antidiarrheal agent with no CNS effects.
f3 f3 f3 f3 f3 f3 f3 f3 f3
Which med? - SOLUTION - Loperamide
f3 f3 f3 f3 f3 f3
9. 35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
profuse, watery diarrhea for 8 hours despite a lack of oral intake.
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Recently returned from a medical relief trip to a remove village in
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows dry skin and
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
decreased capillary refill. Stool for occult blood is negative; stool is
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
gray and turbid. Gram stain shows gram-negative, comma-shaped
f3 f3 f3 f3 f3 f3 f3 f3
bacteria; no erythrocytes of leukocytes. MOA of toxin? - SOLUTION -
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
V. Cholerae--> activates AC
f3 f3 f3 f3
10. 59yo F with gradual onset of lack of muscle control in her left arm
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
and leg. Sx 1 mo ago after dx with metastatic breast cancer. PE
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
shows ataxia of left upper and lower extremities. Muscle strength,
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
DTR, sensation, proprioception normal. Metastatic tumor in which
f3 f3 f3 f3 f3 f3 f3 f3
location? - SOLUTION - Cerebellum
f3 f3 f3 f3 f3
11. Newborn delivered at 38 weeks' gestation weighs 1800 g. PE shows
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
petechial rash, microcephaly, and hepatosplenomegaly. Serologic
f3 f3 f3 f3 f3 f3
Page 2 of 37 f3f4 f3f4 f3f4
, test for CMV: IgG + in mother, + in newborn; IGM - in mother, + in
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
newborn. Explanation? - SOLUTION - Congenital CMV infection
f3 f3 f3 f3 f3 f3 f3 f3
12. Female newborn is delivered at 38 weeks' gestation. Apgar 8 and 8 at
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
1/5 min. PE shows a bulging, fluod0filled mass approximately 5 cm in
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
diameter in the midline over the lumbosacral region. No
f3 f3 f3 f3 f3 f3 f3 f3 f3
spontaneous movements of the lower extremities. Abnormality most
f3 f3 f3 f3 f3 f3 f3 f3
likely occurred because of abnormal development during which
f3 f3 f3 f3 f3 f3 f3 f3
periods of postconception (in days)? - SOLUTION - 15-40; neutral
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
tube closes at about 4 weeks
f3 f3 f3 f3 f3 f3
13. 64yo M in ED 3 hours after SOB with exertion and extreme fatigue.
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Has ischemic heart disease. P 125/min, BP 105/60. ECG shows atrial
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
fibrillation. Intravenous ibutilide is administered. Ten minutes later,
f3 f3 f3 f3 f3 f3 f3 f3
ECG shows normal sinus rhythm. Risk for which drug effect in the
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
next 6 hours? - SOLUTION - Torsades de pointes
f3 f3 f3 f3 f3 f3 f3 f3 f3
14. 65yo F with 20-year hx of osteoarthritis of the hands now has pain
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
radiating down the distal anterior thigh, knee, medial leg, and food.
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Bony outgrowth of vertebrae compressing one of the spinal nerves
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
is suspected. Nerve root in which intervertebral foramina is
f3 f3 f3 f3 f3 f3 f3 f3 f3
effected? - SOLUTION - L3 to L4
f3 f3 f3 f3 f3 f3 f3
15. 38yo M with 3-year hx of T2DM. Taking an oral antihyperglycemic
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
agent, he has tried diet and exercise. BMI 32. PE normal. Hb A1c is
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
10%. Physician recommends initiation of insulin injections. Responds,
f3 f3 f3 f3 f3 f3 f3 f3
"I know that insulin would help control my blood sugar. But a lot of
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
people in my family have diabetes, and insulin made them really sick
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
at times. Patient is at which stage of change? - SOLUTION -
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Contemplation
f3
16. 24yo M with 2-day history of an itchy rash on his arms and legs.
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Returned from a camping trip in the woods 5 days ago. PE shows
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
Page 3 of 37 f3f4 f3f4 f3f4
, f3 edematous, erythematous rash with linear vesicles. Cause is f3 f3 f3 f3 f3 f3 f3
f3 activation of which cell types? - SOLUTION - T-lymphocytes (type IV
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
f3 HS)
17. 70yo M from china with poorly differentiated monoclonal carcinoma
f3 f3 f3 f3 f3 f3 f3 f3
of the nasopharynx. DNA probes of neoplastic cells are most likely to
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
detect genome of which virus? - SOLUTION - EBV
f3 f3 f3 f3 f3 f3 f3 f3 f3
18. 24yo M with hx of IVDA could not be aroused. Friend reports that the
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
patient injected himself with a drug 6 hours ago. Labs show drug
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
concentration of 0.3. Assuming first-order one-compartment
f3 f3 f3 f3 f3 f3
kinetics, has a half-life of 2 hours, and a volume of distribution of 200
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
L in this patient. What is quantity of drug (in mg) injected? -
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
SOLUTION - = 200 (0.3) =60
f3 f3 f3 f3 f3 f3
19. 3 half-lives = 120, 240, 480
f3 f3 f3 f3 f3
20. Compound is taken up by bacterial cells. No energy is f3 f3 f3 f3 f3 f3 f3 f3 f3
f3 necessary for uptake, and the compound is not concentrated in the f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
f3 cell. Which describes this mechanism of transport? - SOLUTION -
f3 f3 f3 f3 f3 f3 f3 f3 f3
f3 Carrier-mediated diffusion f3
21. Newborn has male genital ducts but female external genitalia. f3 f3 f3 f3 f3 f3 f3 f3
Cytogenetic analysis shows a 46,XY karyotype, and genetic testing
f3 f3 f3 f3 f3 f3 f3 f3 f3
shows a mutation of the gene encoding 5alpha-reductase. In
f3 f3 f3 f3 f3 f3 f3 f3 f3
absence of this mutation, labia majora would have been? - SOLUTION
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
- Scrotum
f3 f3
22.Corresponded to penis shaft? - SOLUTION - Labia minora f3 f3 f3 f3 f3 f3 f3 f3
23.Study designed to evaluate the efficacy of coenzyme Q10 in improving
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
cardiac output in patients with CHF. Sixty patients with CHF are
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
recruited. Each assigned by coin toss to one of tw groups. Design? -
f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3 f3
SOLUTION - RCT
f3 f3 f3
Page 4 of 37 f3f4 f3f4 f3f4