Half-Life
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Safe dosage interval. The amount of time it takes a drug to be reduced in
the blood by 50%.
Treatment duration (anti-dep)
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, Initial improvement may be seen 1-2 weeks but typically for the maximum
improvement ranges from 4-12 weeks are required. If no response is seen in
4-8 weeks with the maximally tolerated dose, then options are to switch to
a different antidepressant within the same of different class. After complete
remission of symptoms, antidepressant therapy should continue for at least
4-9 months (you may see up to 12 months). Individuals who have had 3 or
more episodes of depression, most likely will need continuous
maintenance therapy. You may see two or more episodes in some of the
literature as well. Be sure to use the guidelines as your guide, but make
your plans patient specific.
Acetylcholine: MOA/purpose
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In lesser amounts, Ach can act like a stimulant by releasing norepinephrine
& dopamine.
Memory
Motivation
higher order thought process
sexual desire an activity
sleep
Melatonin congeners ie ramelteon
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Melatonin 1&2 receptor agonists.
Bind selectively to melatonin 1&2 receptors as a full agonist.
Primary use is for insomnia-reduces time to sleep onset, increases total
sleep time, & may improve quality of care.
,Treatment refractory depression
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typically refers to unipolar major depression episodes that do not respond
satisfactorily to numerous sequential treatment regimens.
Food to increase dopamine
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chicken, almonds, apples, avocado, bananas, beets, chocolate, green leafy
vegetables, green tea, lima bean, sesame and pumpkin seeds, turmeric,
watermelon and wheat germ.
NE found in:
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brain: locus ceruleus, projecting to cortex, for arousal, attention and
anxiety.
ANS: sympathetic neurons
NE used in rx of:
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, ADHD
Anxiety
Cardiac failure
Serotonin used in rx of:
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Depression
Sleep regulation
How to choose a therapeutic agent: depression:
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1. What are the most bothersome sx? (anxious, energized, vegetative,
altered sleep, alltered sex drive, appetite change, hypersomnia).
mnemonic for TCA's (trans, chans, ans)
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Trans: transmitters: SE, NE
Chans: channels: Na & Ca
Ans: antagonist: AcH & His
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Safe dosage interval. The amount of time it takes a drug to be reduced in
the blood by 50%.
Treatment duration (anti-dep)
Give this one a try later!
, Initial improvement may be seen 1-2 weeks but typically for the maximum
improvement ranges from 4-12 weeks are required. If no response is seen in
4-8 weeks with the maximally tolerated dose, then options are to switch to
a different antidepressant within the same of different class. After complete
remission of symptoms, antidepressant therapy should continue for at least
4-9 months (you may see up to 12 months). Individuals who have had 3 or
more episodes of depression, most likely will need continuous
maintenance therapy. You may see two or more episodes in some of the
literature as well. Be sure to use the guidelines as your guide, but make
your plans patient specific.
Acetylcholine: MOA/purpose
Give this one a try later!
In lesser amounts, Ach can act like a stimulant by releasing norepinephrine
& dopamine.
Memory
Motivation
higher order thought process
sexual desire an activity
sleep
Melatonin congeners ie ramelteon
Give this one a try later!
Melatonin 1&2 receptor agonists.
Bind selectively to melatonin 1&2 receptors as a full agonist.
Primary use is for insomnia-reduces time to sleep onset, increases total
sleep time, & may improve quality of care.
,Treatment refractory depression
Give this one a try later!
typically refers to unipolar major depression episodes that do not respond
satisfactorily to numerous sequential treatment regimens.
Food to increase dopamine
Give this one a try later!
chicken, almonds, apples, avocado, bananas, beets, chocolate, green leafy
vegetables, green tea, lima bean, sesame and pumpkin seeds, turmeric,
watermelon and wheat germ.
NE found in:
Give this one a try later!
brain: locus ceruleus, projecting to cortex, for arousal, attention and
anxiety.
ANS: sympathetic neurons
NE used in rx of:
Give this one a try later!
, ADHD
Anxiety
Cardiac failure
Serotonin used in rx of:
Give this one a try later!
Depression
Sleep regulation
How to choose a therapeutic agent: depression:
Give this one a try later!
1. What are the most bothersome sx? (anxious, energized, vegetative,
altered sleep, alltered sex drive, appetite change, hypersomnia).
mnemonic for TCA's (trans, chans, ans)
Give this one a try later!
Trans: transmitters: SE, NE
Chans: channels: Na & Ca
Ans: antagonist: AcH & His
