AORN Periop 101 – Perioperative Nursing, Patient Safety & Surgical Procedures | 420 Exam Questions with Answers | Chamberlain University 2026

This document contains 420 comprehensive AORN Periop 101 final exam practice questions with detailed answers designed to help students review essential perioperative nursing knowledge required for operating room practice and certification preparation. The material is organized in a question-and-answer format that focuses on critical perioperative concepts including legal and ethical responsibilities in nursing practice, anesthesia principles, perioperative patient assessment, infection prevention, sterile technique, surgical instrumentation, patient positioning, hemostasis methods, and operating room safety protocols. These topics represent core competencies required for safe surgical patient care and are commonly tested in perioperative nursing examinations. The document covers a wide range of perioperative clinical knowledge including malpractice and liability concepts, informed consent requirements, anesthesia types and reversal agents, malignant hyperthermia recognition and management, hypothermia risk factors, perioperative medication safety, surgical fire prevention, sterile field maintenance, surgical draping techniques, surgical wound classifications, and infection transmission prevention. Additional sections review gas insufflation safety in minimally invasive surgery, robotic surgery benefits, patient positioning techniques such as supine, lithotomy, lateral, and prone positions, pressure injury staging, and surgical environment zoning (restricted, semi-restricted, and unrestricted areas). For example, early sections of the document outline legal concepts such as liability, negligence, and malpractice, while later sections discuss sterile processing, biological indicators for sterilization, and proper handling of surgical instruments used during procedures (pages 1–70). The content closely aligns with the Association of periOperative Registered Nurses (AORN) Periop 101: A Core Curriculum™ training program and supports learning objectives found in leading perioperative nursing textbooks such as “Alexander’s Care of the Patient in Surgery” and “Berry & Kohn’s Operating Room Technique.” These texts are widely used in nursing schools, hospital perioperative training programs, and surgical technology programs to teach foundational principles of operating room nursing, sterile processing, and surgical safety. The questions reinforce clinical reasoning and procedural knowledge related to anesthesia monitoring, perioperative documentation, surgical instrument handling, infection control, and patient safety standards in the surgical environment. This document may be particularly useful for students enrolled in perioperative nursing, surgical nursing, operating room nursing orientation programs, and surgical technology courses. It is relevant for learners preparing for AORN Periop 101 final exams, hospital perioperative competency assessments, or CNOR certification preparation. Programs that may benefit from this material include RN perioperative residency programs, transition-to-operating-room training programs, perioperative clinical practicums, surgical technology diploma programs, and advanced nursing clinical skills courses. Students from institutions such as Chamberlain University, Walden University, Purdue University Global, Herzing University, Rasmussen University, and other nursing schools offering perioperative education may find this document helpful for exam preparation, clinical review, and reinforcing key operating room safety practices. Keywords: AORN periop 101 final exam questions, perioperative nursing exam preparation, operating room nursing practice questions, perioperative patient safety guidelines, sterile technique operating room nursing, anesthesia types perioperative nursing review, malignant hyperthermia management nursing, perioperative infection prevention guidelines, surgical draping and sterile field management, surgical wound classification nursing, perioperative medication safety practices, surgical fire risk prevention nursing, operating room environmental zones guidelines, perioperative patient positioning safety, surgical hemostasis techniques nursing, sterile processing and instrument sterilization review, perioperative documentation standards nursing, CNOR exam preparation questions, surgical instrumentation identification review, perioperative nursing competency exam review