BLOCK 6 - EXAM 3 CONTENT| TOP SCORES MADE
SIMPLE | TRUSTED TEST SOLUTIONS!
What drugs are Antimetabolites Answer: - gemcitabine
- cytarabine
- fludarabine
- 6-MP
- methotrexate
- gemcitabine
- cytarabine
- fludarabine
- 6-MP
What type of drugs? Answer: Antimetabolite drugs
- gemcitabine
- cytarabine
- fludarabine
- 6-MP
MOA Answer: Antimetabolites that prevent DNA precursor (dATP, dCTP, etc.) synthesis
and/or get incorporated into DNA
- substituted nucleotide bases or ribose
Antimetabolites that prevent DNA precursor (dATP, dCTP, etc.) synthesis and/or get
incorporated into DNA
- substituted nucleotide bases or ribose
MOA of what drugs? Answer: - gemcitabine
- cytarabine
- fludarabine
- 6-MP
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,Methotrexate MOA Answer: Antimetabolite that is a folate analog
- Prevent DNA precursor (dATP, dCTP, etc.) synthesis and/or get incorporated into DNA
Antimetabolite that is a folate analog
- Prevent DNA precursor (dATP, dCTP, etc.) synthesis and/or get incorporated into DNA
Answer: Methotrexate
- gemcitabine
- cytarabine
- fludarabine
- 6-MP
Clinical use Answer: Leukemias and lymphomas
Methotrexate clinical use Answer: ALL and lymphomas
What drugs are Alkylators Answer: - Cyclophosphamide
- Chlorambucil
- Mechlorethamine
- Procarbazine
- Dacarbazine
- Bendamustine
- Carboplatin
- Cyclophosphamide
- Chlorambucil
- Mechlorethamine
- Procarbazine
- Dacarbazine
- Bendamustine
- Carboplatin
What type of drugs? Answer: Alkylators
- Cyclophosphamide
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,- Chlorambucil
- Mechlorethamine
- Procarbazine
- Dacarbazine
- Bendamustine
- Carboplatin
MOA Answer: Alkylators that bind covalently at 1 or 2 (cross-linking) N7 of guanine on
one or both strands of DNA
Drugs that bind covalently at 1 or 2 (cross-linking) N7 of guanine on one or both strands
of DNA Answer: Alkylators
- Cyclophosphamide
- Chlorambucil
- Mechlorethamine
- Procarbazine
- Dacarbazine
- Bendamustine
- Carboplatin
Cyclophosphamide adverse effects Answer: Hemorrhagic cystitis
Hemorrhagic cystitis is an adverse effect of what alkylator? Answer: Cyclophosphamide
Chlorambucil, mechlorethamine, procarbazine, dacarbazine, bendamustine adverse
effects Answer: Pulmonary toxicity
Pulmonary toxicity is an adverse effect of what alkylators? Answer: Chlorambucil,
mechlorethamine, procarbazine, dacarbazine, bendamustine
Antibiotics used for leukemia and lymphomas Answer: - Doxorubicin, daunorubicin
- Bleomycin
Doxorubicin, daunorubicin, and bleomycin MOA Answer: Antibiotics that intercalate
DNA non-covalently generate free radicals -> DNA strand breaks
Antibiotics that intercalate DNA non-covalently generate free radicals -> DNA strand
breaks Answer: Doxorubicin, daunorubicin, and bleomycin
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, What antibiotics used for leukemia and lymphomas can cause cumulative
cardiotoxicity? Answer: Doxorubicin, daunorubiciin
What antibiotics used for leukemia and lymphomas are unlikely to cause bone marrow
suppression Answer: Bleomycin
What drugs are Alkaloids Answer: Etoposide, teniposide
Etoposide, teniposide is what type of drug? Answer: Alkaloids
Etoposide, teniposide MOA Answer: Alkaloids that inhibit topoisomerase II
Alkaloids that inhibit topoisomerase II Answer: Etoposide, teniposide
Vincristine, vinblastin MOA Answer: Bind tubulin to prevent polymerization into
microtubules or mitotic spindles
Drugs that bind tubulin to prevent polymerization into microtubules or mitotic spindles
Answer: Vincristine, vinblastin
Vincristine, vinblastin adverse effects Answer: Peripheral neuropathy
Peripheral neuropathy is an adverse effect of what drugs used for leukemia and
lymphoma? Answer: Vincristine, vinblastin
Hydroxyurea MOA in leukemia and lymphoma? Answer: Inhibits ribonucleotide
[diphosphate] reductase -> DNA synthesis
What drugs inhibits ribonucleotide [diphosphate] reductase -> DNA synthesis Answer:
Hydroxyurea
Asparaginase, pegaspargase MOA Answer: Catalyze L-asparagine -> ammonia +
aspartate (ALL) arsenic (trioxide) causes degradation of PML-RAR-alpha mutant fusion
protein (APL)
What drugs catalyze L-asparagine -> ammonia + aspartate (ALL) arsenic (trioxide)
causes degradation of PML-RAR-alpha mutant fusion protein (APL) Answer:
Asparaginase, pegaspargase
Corticosteroids used for leukemias and lymphomas Answer: Prednisone,
dexamethasone
What drugs activate Glucocorticoid Receptor to decrease lymphocyte proliferation;
induce apoptosis Answer: Prednisone, dexamethasone
Prednisone, dexamethasone MOA Answer: Activate Glucocorticoid Receptor to
decrease lymphocyte proliferation; induce apoptosis
Rituximab MOA Answer: Monoclonal antibody that binds CD20 on B-cells
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SIMPLE | TRUSTED TEST SOLUTIONS!
What drugs are Antimetabolites Answer: - gemcitabine
- cytarabine
- fludarabine
- 6-MP
- methotrexate
- gemcitabine
- cytarabine
- fludarabine
- 6-MP
What type of drugs? Answer: Antimetabolite drugs
- gemcitabine
- cytarabine
- fludarabine
- 6-MP
MOA Answer: Antimetabolites that prevent DNA precursor (dATP, dCTP, etc.) synthesis
and/or get incorporated into DNA
- substituted nucleotide bases or ribose
Antimetabolites that prevent DNA precursor (dATP, dCTP, etc.) synthesis and/or get
incorporated into DNA
- substituted nucleotide bases or ribose
MOA of what drugs? Answer: - gemcitabine
- cytarabine
- fludarabine
- 6-MP
1
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,Methotrexate MOA Answer: Antimetabolite that is a folate analog
- Prevent DNA precursor (dATP, dCTP, etc.) synthesis and/or get incorporated into DNA
Antimetabolite that is a folate analog
- Prevent DNA precursor (dATP, dCTP, etc.) synthesis and/or get incorporated into DNA
Answer: Methotrexate
- gemcitabine
- cytarabine
- fludarabine
- 6-MP
Clinical use Answer: Leukemias and lymphomas
Methotrexate clinical use Answer: ALL and lymphomas
What drugs are Alkylators Answer: - Cyclophosphamide
- Chlorambucil
- Mechlorethamine
- Procarbazine
- Dacarbazine
- Bendamustine
- Carboplatin
- Cyclophosphamide
- Chlorambucil
- Mechlorethamine
- Procarbazine
- Dacarbazine
- Bendamustine
- Carboplatin
What type of drugs? Answer: Alkylators
- Cyclophosphamide
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,- Chlorambucil
- Mechlorethamine
- Procarbazine
- Dacarbazine
- Bendamustine
- Carboplatin
MOA Answer: Alkylators that bind covalently at 1 or 2 (cross-linking) N7 of guanine on
one or both strands of DNA
Drugs that bind covalently at 1 or 2 (cross-linking) N7 of guanine on one or both strands
of DNA Answer: Alkylators
- Cyclophosphamide
- Chlorambucil
- Mechlorethamine
- Procarbazine
- Dacarbazine
- Bendamustine
- Carboplatin
Cyclophosphamide adverse effects Answer: Hemorrhagic cystitis
Hemorrhagic cystitis is an adverse effect of what alkylator? Answer: Cyclophosphamide
Chlorambucil, mechlorethamine, procarbazine, dacarbazine, bendamustine adverse
effects Answer: Pulmonary toxicity
Pulmonary toxicity is an adverse effect of what alkylators? Answer: Chlorambucil,
mechlorethamine, procarbazine, dacarbazine, bendamustine
Antibiotics used for leukemia and lymphomas Answer: - Doxorubicin, daunorubicin
- Bleomycin
Doxorubicin, daunorubicin, and bleomycin MOA Answer: Antibiotics that intercalate
DNA non-covalently generate free radicals -> DNA strand breaks
Antibiotics that intercalate DNA non-covalently generate free radicals -> DNA strand
breaks Answer: Doxorubicin, daunorubicin, and bleomycin
3
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, What antibiotics used for leukemia and lymphomas can cause cumulative
cardiotoxicity? Answer: Doxorubicin, daunorubiciin
What antibiotics used for leukemia and lymphomas are unlikely to cause bone marrow
suppression Answer: Bleomycin
What drugs are Alkaloids Answer: Etoposide, teniposide
Etoposide, teniposide is what type of drug? Answer: Alkaloids
Etoposide, teniposide MOA Answer: Alkaloids that inhibit topoisomerase II
Alkaloids that inhibit topoisomerase II Answer: Etoposide, teniposide
Vincristine, vinblastin MOA Answer: Bind tubulin to prevent polymerization into
microtubules or mitotic spindles
Drugs that bind tubulin to prevent polymerization into microtubules or mitotic spindles
Answer: Vincristine, vinblastin
Vincristine, vinblastin adverse effects Answer: Peripheral neuropathy
Peripheral neuropathy is an adverse effect of what drugs used for leukemia and
lymphoma? Answer: Vincristine, vinblastin
Hydroxyurea MOA in leukemia and lymphoma? Answer: Inhibits ribonucleotide
[diphosphate] reductase -> DNA synthesis
What drugs inhibits ribonucleotide [diphosphate] reductase -> DNA synthesis Answer:
Hydroxyurea
Asparaginase, pegaspargase MOA Answer: Catalyze L-asparagine -> ammonia +
aspartate (ALL) arsenic (trioxide) causes degradation of PML-RAR-alpha mutant fusion
protein (APL)
What drugs catalyze L-asparagine -> ammonia + aspartate (ALL) arsenic (trioxide)
causes degradation of PML-RAR-alpha mutant fusion protein (APL) Answer:
Asparaginase, pegaspargase
Corticosteroids used for leukemias and lymphomas Answer: Prednisone,
dexamethasone
What drugs activate Glucocorticoid Receptor to decrease lymphocyte proliferation;
induce apoptosis Answer: Prednisone, dexamethasone
Prednisone, dexamethasone MOA Answer: Activate Glucocorticoid Receptor to
decrease lymphocyte proliferation; induce apoptosis
Rituximab MOA Answer: Monoclonal antibody that binds CD20 on B-cells
4
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