Toxicology Exam 1 Questions with
Verified Solutions
1.Which of the following describes a type B reaction?
a.Most commonly reported in humans
b.Predictable
c.Resolves only when treatment is discontinued
d.Dose-dependent - ANS-c.Resolves only when treatment is discontinued
1.Which of these requirements are necessary before a toxic effect can occur?
a.Toxicant must reach target organ at effective concentration
b.Toxicant must reach target organ for a sufficient length of time
c.Toxicant must reach target organ in a susceptible biological system
d.All of the above - ANS-d.All of the above
1.Naloxone is a medication that quickly reverses an opioid overdose. Which is the least
likely to be used as a route of administration?
a.Intramuscular
b.Inhalation
c.Intravenous
d.Dermal - ANS-d.Dermal
1.A child goes to see his pediatrician because he has a sore throat. He is diagnosed
with strep throat and is prescribed Amoxicillin. The next day, he develops hives all over
his body. What type of adverse drug reaction is this?
a.Type A reaction
b.Type B reaction
c.Pharmacologic reaction
d.B and C - ANS-b. Type B reaction
True or False: Ingestion of a toxicant/toxin is faster than inhalation - ANS-False,
inhalation is faster
The type of antagonism that alters the concentration at the target organ is:
a.Functional antagonism
b.Chemical antagonism
, c.Dispositional antagonism
d.Receptor antagonism - ANS-c.Dispositional antagonism
True or false: Type A reactions are not related to the pharmacology of the drug - ANS-
False
Which organ most frequently experiences systemic toxicity?
a. Muscles and bones
b. Blood and hematopoietic tissue
c. Viscera
d. CNS - ANS-d.CNS
Which of the following is NOT true about chronic inflammation?
a.Occurs over a prolonged duration
b.May be caused by autoimmune disease
c.May lead to fibrosis
d.Involves fluid and plasma leakage from capillaries - ANS-d.Involves fluid and plasma
leakage from capillaries
True or False: Chlorine gas is considered to be highly reactive, and it is most likely to
show local symptoms - ANS-True
First Pass Effect will cause
a.Low bioavailability due to decrease metabolism in the liver
b.Low bioavailability due to increase metabolism in the liver
c.High bioavailability due to increase metabolism in the liver
d.High bioavailability due to decrease metabolism in the liver - ANS-b.Low bioavailability
due to increase metabolism in the liver
Which is FALSE regarding free radicals
a.Unstable due to the unpaired electrons
b.Can propagate to create other radicles
c.Linked to heart disease and cancer
d.Our bodies cannot combat them - ANS-d.Our bodies cannot combat them
Termination of inflammation occurs when:
a.The original stimulus is removed
b.The host passes out
c.Mediators are dissipated or inhibited
d.Both A and C - ANS-d.Both A and C
Verified Solutions
1.Which of the following describes a type B reaction?
a.Most commonly reported in humans
b.Predictable
c.Resolves only when treatment is discontinued
d.Dose-dependent - ANS-c.Resolves only when treatment is discontinued
1.Which of these requirements are necessary before a toxic effect can occur?
a.Toxicant must reach target organ at effective concentration
b.Toxicant must reach target organ for a sufficient length of time
c.Toxicant must reach target organ in a susceptible biological system
d.All of the above - ANS-d.All of the above
1.Naloxone is a medication that quickly reverses an opioid overdose. Which is the least
likely to be used as a route of administration?
a.Intramuscular
b.Inhalation
c.Intravenous
d.Dermal - ANS-d.Dermal
1.A child goes to see his pediatrician because he has a sore throat. He is diagnosed
with strep throat and is prescribed Amoxicillin. The next day, he develops hives all over
his body. What type of adverse drug reaction is this?
a.Type A reaction
b.Type B reaction
c.Pharmacologic reaction
d.B and C - ANS-b. Type B reaction
True or False: Ingestion of a toxicant/toxin is faster than inhalation - ANS-False,
inhalation is faster
The type of antagonism that alters the concentration at the target organ is:
a.Functional antagonism
b.Chemical antagonism
, c.Dispositional antagonism
d.Receptor antagonism - ANS-c.Dispositional antagonism
True or false: Type A reactions are not related to the pharmacology of the drug - ANS-
False
Which organ most frequently experiences systemic toxicity?
a. Muscles and bones
b. Blood and hematopoietic tissue
c. Viscera
d. CNS - ANS-d.CNS
Which of the following is NOT true about chronic inflammation?
a.Occurs over a prolonged duration
b.May be caused by autoimmune disease
c.May lead to fibrosis
d.Involves fluid and plasma leakage from capillaries - ANS-d.Involves fluid and plasma
leakage from capillaries
True or False: Chlorine gas is considered to be highly reactive, and it is most likely to
show local symptoms - ANS-True
First Pass Effect will cause
a.Low bioavailability due to decrease metabolism in the liver
b.Low bioavailability due to increase metabolism in the liver
c.High bioavailability due to increase metabolism in the liver
d.High bioavailability due to decrease metabolism in the liver - ANS-b.Low bioavailability
due to increase metabolism in the liver
Which is FALSE regarding free radicals
a.Unstable due to the unpaired electrons
b.Can propagate to create other radicles
c.Linked to heart disease and cancer
d.Our bodies cannot combat them - ANS-d.Our bodies cannot combat them
Termination of inflammation occurs when:
a.The original stimulus is removed
b.The host passes out
c.Mediators are dissipated or inhibited
d.Both A and C - ANS-d.Both A and C
