Pharm Tox Exam I with Complete
Solutions
The number one determining factor that determines the amount of drug delivered to the
tissues is _____. - ANS-perfusion rates
The parameter on a log dose response curve which describes the amount of a response
of effect of a given dose of a drug is known as _____. - ANS-efficacy
Name two inhibitory neurotransmitters. - ANS-GABA, glycine
_____ must be completely eliminated from the diet in order to prevent a possible
hypertensive crisis with patients taking MAO-inhibitors. - ANS-tyramine
The side effect profile of the selective serotonergic reuptake inhibitors (SSRI) does NOT
include weight _____. - ANS-gain
Most anxiolytic and sedative-hypnotic agents belong to a family of drugs known as
_____. - ANS-benzodiazepines
T/F With regards to lipid: water partition coefficient, the lower the partition coefficient,
the greater the absorption. - ANS-false; increased coefficient = increased absorption
T/F With regards to lipid: water partition coefficient, ionized, water-soluble drugs are
more readily absorbed. - ANS-false; fat soluble drugs are more readily absorbed
Describe the correct order of neurotransmitter synthesis. - ANS-tyrosine->L-DOPA-
>dopamine->norepi->epi
_____ is used for clinical depression and has been demonstrated to decrease seizure
threshold in selected patients. More recently it has been demonstrated to decrease the
cravings of nicotine. - ANS-bupropion (wellbutrin)
Fluoxetine (Prozac), Sertraline (Zoloft), and Paroxetine (Paxil) all share a common
feature in that they selectively increase the levels of _____. - ANS-5-hydroxytryptamine
(serotonin)
A psychotherapeutic agent which has been approved by the FDA for symptoms
consistent with Obsessive-Compulsive disorder is _____. - ANS-clomipramine
(anafranil)
, _____ would be seen in a patient whose muscarinic receptors were stimulated when
they received a direct acting cholinomimetic. - ANS-bradycardia
_____ would be seen in a patient whose muscarinic receptors were stimulated when
they received an indirect acting cholinomimetic. - ANS-miosis
T/F Botulism causes increased release of ACh from the nerve terminus. - ANS-false;
botulism prevents the release of ACh
A beta one receptor antagonist would be used to treat _____. - ANS-essential
hypertension
T/F Organophosphate insecticides cause mydriasis. - ANS-false; organophosphate
insecticides cause pupillary constriction
A patient of yours presents with symptoms of a sleep disturbance. He reports that over
the past two weeks he has been unable to sleep for the duration of the night. He falls
asleep without difficulty, but then wakes up 2 to 3 times during the night. The clinical
picture is one suggestive of _____. - ANS-parasomnia
Following first-pass metabolism, the blood levels of Amitriptyline (Elavil) can now be
evaluated by monitoring its active metabolite _____. - ANS-nortriptyline (pamelor)
The intraneuronal degradation of catecholamines in the pre-synaptic neuron is carried
out by _____. - ANS-monoamine oxidase
Gamma-amino-butyric acid (GABA) functions by binding to cell receptors to _____. -
ANS-hyperpolarize the cell body by increasing chloride conductance
The addition of glucuronic acid to a drug is an example of a _____ reaction. - ANS-
phase II
A new patient presents to your clinic for her first visit. During your initial evaluation, the
patient reports a three month history of progressive fatigue, malaise, irritability, and
mood swings. She is experiencing anergia and hyper somnolence. She has crying
spells and is becoming increasingly isolated. What is the most appropriate
recommendation during your initial visit? - ANS-order a CBC and thyroid panel to rule
out anemia and/or thyroid dysfunction
T/F Sedative-hypnotic agents increase REM sleep cycle of sleep patterns. - ANS-false
What effect does an indirect acting cholinomimetic have upon intestinal motility? - ANS-
increases it
Failure to produce further clinical response when higher doses of a drug are given is
due to _____. - ANS-saturation of the receptors with the drug
Solutions
The number one determining factor that determines the amount of drug delivered to the
tissues is _____. - ANS-perfusion rates
The parameter on a log dose response curve which describes the amount of a response
of effect of a given dose of a drug is known as _____. - ANS-efficacy
Name two inhibitory neurotransmitters. - ANS-GABA, glycine
_____ must be completely eliminated from the diet in order to prevent a possible
hypertensive crisis with patients taking MAO-inhibitors. - ANS-tyramine
The side effect profile of the selective serotonergic reuptake inhibitors (SSRI) does NOT
include weight _____. - ANS-gain
Most anxiolytic and sedative-hypnotic agents belong to a family of drugs known as
_____. - ANS-benzodiazepines
T/F With regards to lipid: water partition coefficient, the lower the partition coefficient,
the greater the absorption. - ANS-false; increased coefficient = increased absorption
T/F With regards to lipid: water partition coefficient, ionized, water-soluble drugs are
more readily absorbed. - ANS-false; fat soluble drugs are more readily absorbed
Describe the correct order of neurotransmitter synthesis. - ANS-tyrosine->L-DOPA-
>dopamine->norepi->epi
_____ is used for clinical depression and has been demonstrated to decrease seizure
threshold in selected patients. More recently it has been demonstrated to decrease the
cravings of nicotine. - ANS-bupropion (wellbutrin)
Fluoxetine (Prozac), Sertraline (Zoloft), and Paroxetine (Paxil) all share a common
feature in that they selectively increase the levels of _____. - ANS-5-hydroxytryptamine
(serotonin)
A psychotherapeutic agent which has been approved by the FDA for symptoms
consistent with Obsessive-Compulsive disorder is _____. - ANS-clomipramine
(anafranil)
, _____ would be seen in a patient whose muscarinic receptors were stimulated when
they received a direct acting cholinomimetic. - ANS-bradycardia
_____ would be seen in a patient whose muscarinic receptors were stimulated when
they received an indirect acting cholinomimetic. - ANS-miosis
T/F Botulism causes increased release of ACh from the nerve terminus. - ANS-false;
botulism prevents the release of ACh
A beta one receptor antagonist would be used to treat _____. - ANS-essential
hypertension
T/F Organophosphate insecticides cause mydriasis. - ANS-false; organophosphate
insecticides cause pupillary constriction
A patient of yours presents with symptoms of a sleep disturbance. He reports that over
the past two weeks he has been unable to sleep for the duration of the night. He falls
asleep without difficulty, but then wakes up 2 to 3 times during the night. The clinical
picture is one suggestive of _____. - ANS-parasomnia
Following first-pass metabolism, the blood levels of Amitriptyline (Elavil) can now be
evaluated by monitoring its active metabolite _____. - ANS-nortriptyline (pamelor)
The intraneuronal degradation of catecholamines in the pre-synaptic neuron is carried
out by _____. - ANS-monoamine oxidase
Gamma-amino-butyric acid (GABA) functions by binding to cell receptors to _____. -
ANS-hyperpolarize the cell body by increasing chloride conductance
The addition of glucuronic acid to a drug is an example of a _____ reaction. - ANS-
phase II
A new patient presents to your clinic for her first visit. During your initial evaluation, the
patient reports a three month history of progressive fatigue, malaise, irritability, and
mood swings. She is experiencing anergia and hyper somnolence. She has crying
spells and is becoming increasingly isolated. What is the most appropriate
recommendation during your initial visit? - ANS-order a CBC and thyroid panel to rule
out anemia and/or thyroid dysfunction
T/F Sedative-hypnotic agents increase REM sleep cycle of sleep patterns. - ANS-false
What effect does an indirect acting cholinomimetic have upon intestinal motility? - ANS-
increases it
Failure to produce further clinical response when higher doses of a drug are given is
due to _____. - ANS-saturation of the receptors with the drug
