NR507 Advanced Pathophysiology
MidTerm
(Latest 2025-2026 Edition) 100% Verified Q&A + Answer
55+
Key Solutions
VERIFIED ANSWERS
Question 1
Hypersensitivity: Type 1
Correct Answer
Type 1: Allergic reaction, Mediated by IgE, Inflammation due to mast cell degranulation
Local symptoms:
-itching
-rash
Systemic symptoms:
-wheezing
Most dangerous = anaphylactic reaction
systemic response of hypotension, severe bronchoconstriction
Main treatment: epinephrine reverses the effects
Question 2
Hypersensitivity: Type 2
Correct Answer
Type 2: Cytotoxic reaction; tissue specific (ex: thyroid tissue)
Macrophages are the primary effectors cells involved
Can cause tissue damage or alter function
Grave's disease (hyperthyroidism) - example of altering thyroid function, but does not destroy thyroid tissue
Incompatible blood type- example of cell/tissue damage that occurs; severe transfusion reaction occurs and the
transfused erythrocytes are destroyed by agglutination or complement-mediated lysis.
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, Question 3
Type 1 Hypersensitivity VS. Type 2 Hypersensitivity
Correct Answer
Type 1 Hypersensitivity
Organ Specific
Antibody binds to the antigen on the cell surface
Type 2 Hypersensitivity
Not Organ Specific
Antibody binds to the soluble antigen outside the cell surface that was released into the blood or body fluids, and the
complex is then deposited in the tissues
Question 4
Hypersensitivity: Type 3 - Examples
Correct Answer
Rheumatoid arthritis: Antigen/antibodies are deposited in the joints
Systemic Lupus Erythematosus (SLE)- very closely related to autoimmunity- antigen/antibodies deposit in organs that
cause tissue damage
Question 5
Hypersensitivity: Type 4
Correct Answer
Delayed response
Does not involve antigen/antibody complexes like Types 1, 2 and 3
Is T-cell mediated
Question 6
Differentiating Between the Rash of a Type 1 vs. Type 4 Reaction:
Correct Answer
Type 1: Immediate hypersensitivity reactions, termed atopic dermatitis, are usually characterized by widely distributed
lesions
Type 4: Contact dermatitis (delayed hypersensitivity) consists of lesions only at the site of contact with the allergen
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex would be poison ivy
Trusted by thousands of students and professionals worldwide Page 2 of 15
MidTerm
(Latest 2025-2026 Edition) 100% Verified Q&A + Answer
55+
Key Solutions
VERIFIED ANSWERS
Question 1
Hypersensitivity: Type 1
Correct Answer
Type 1: Allergic reaction, Mediated by IgE, Inflammation due to mast cell degranulation
Local symptoms:
-itching
-rash
Systemic symptoms:
-wheezing
Most dangerous = anaphylactic reaction
systemic response of hypotension, severe bronchoconstriction
Main treatment: epinephrine reverses the effects
Question 2
Hypersensitivity: Type 2
Correct Answer
Type 2: Cytotoxic reaction; tissue specific (ex: thyroid tissue)
Macrophages are the primary effectors cells involved
Can cause tissue damage or alter function
Grave's disease (hyperthyroidism) - example of altering thyroid function, but does not destroy thyroid tissue
Incompatible blood type- example of cell/tissue damage that occurs; severe transfusion reaction occurs and the
transfused erythrocytes are destroyed by agglutination or complement-mediated lysis.
Trusted by thousands of students and professionals worldwide Page 1 of 15
, Question 3
Type 1 Hypersensitivity VS. Type 2 Hypersensitivity
Correct Answer
Type 1 Hypersensitivity
Organ Specific
Antibody binds to the antigen on the cell surface
Type 2 Hypersensitivity
Not Organ Specific
Antibody binds to the soluble antigen outside the cell surface that was released into the blood or body fluids, and the
complex is then deposited in the tissues
Question 4
Hypersensitivity: Type 3 - Examples
Correct Answer
Rheumatoid arthritis: Antigen/antibodies are deposited in the joints
Systemic Lupus Erythematosus (SLE)- very closely related to autoimmunity- antigen/antibodies deposit in organs that
cause tissue damage
Question 5
Hypersensitivity: Type 4
Correct Answer
Delayed response
Does not involve antigen/antibody complexes like Types 1, 2 and 3
Is T-cell mediated
Question 6
Differentiating Between the Rash of a Type 1 vs. Type 4 Reaction:
Correct Answer
Type 1: Immediate hypersensitivity reactions, termed atopic dermatitis, are usually characterized by widely distributed
lesions
Type 4: Contact dermatitis (delayed hypersensitivity) consists of lesions only at the site of contact with the allergen
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex would be poison ivy
Trusted by thousands of students and professionals worldwide Page 2 of 15
