Concept #1: Schizophrenia Diagnosis
Give this one a try later!
nMajor symptoms (> 2 for at least 1 month)
qDelusions
qHallucinations
qDisorganized speech
qGrossly disorganized or catatonic behavior
qNegative symptoms
High-Potency Agents
Give this one a try later!
, •Haloperidol (Haldol)
•Butyrophenone family
•Principal indications: Schizophrenia and acute psychosis
•Preferred agent for Tourette's syndrome
•Adverse effects
•Extrapyramidal reactions
•Neuroendocrine effects
•Can prolong the QT interval and cause dysrhythmias
•
Treatment Guidelines
Give this one a try later!
•First-Line: Most prefer SGAs
•Some exclude olanzapine (metabolic effects) Some include FGAs
•Second-Line: SGA or FGA
•Some recommend an FGA only if an SGA was tried first
•Some include clozapine
•Many reserve clozapine for third-line
•Exception made if patient is suicidal
Olanzapine (Zyprexa®)
Give this one a try later!
, •Structurally similar to clozapine, and has similar pharmacology
•Not associated with agranulocytosis
•Side effects:
•Metabolic side effects - high
•Sedation
•Hypotension
•Weight gain
•
Concept #2: Role of side effects in treatment selection
Give this one a try later!
nHaloperidol: high potency FGA
qHad EPS and hyperprolactinemia
qAvoid agents with similar profiles
nPerphenazine: high potency FGA
nHyperprolactemia: avoid risperidone and paliperidone
nLurasidone: akathisia
qAvoid agents with similar profiles
nBrexpiprazole
nCariprazine
n(Aripiprazole)
Additional References
Give this one a try later!
Give this one a try later!
nMajor symptoms (> 2 for at least 1 month)
qDelusions
qHallucinations
qDisorganized speech
qGrossly disorganized or catatonic behavior
qNegative symptoms
High-Potency Agents
Give this one a try later!
, •Haloperidol (Haldol)
•Butyrophenone family
•Principal indications: Schizophrenia and acute psychosis
•Preferred agent for Tourette's syndrome
•Adverse effects
•Extrapyramidal reactions
•Neuroendocrine effects
•Can prolong the QT interval and cause dysrhythmias
•
Treatment Guidelines
Give this one a try later!
•First-Line: Most prefer SGAs
•Some exclude olanzapine (metabolic effects) Some include FGAs
•Second-Line: SGA or FGA
•Some recommend an FGA only if an SGA was tried first
•Some include clozapine
•Many reserve clozapine for third-line
•Exception made if patient is suicidal
Olanzapine (Zyprexa®)
Give this one a try later!
, •Structurally similar to clozapine, and has similar pharmacology
•Not associated with agranulocytosis
•Side effects:
•Metabolic side effects - high
•Sedation
•Hypotension
•Weight gain
•
Concept #2: Role of side effects in treatment selection
Give this one a try later!
nHaloperidol: high potency FGA
qHad EPS and hyperprolactinemia
qAvoid agents with similar profiles
nPerphenazine: high potency FGA
nHyperprolactemia: avoid risperidone and paliperidone
nLurasidone: akathisia
qAvoid agents with similar profiles
nBrexpiprazole
nCariprazine
n(Aripiprazole)
Additional References
Give this one a try later!
