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COMSAE Phase 1 2026 – Fully Explained Comprehensive Study Guide for COMLEX Level 1

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Complete COMSAE Phase 1 2026 Study Guide designed for osteopathic medical students preparing for COMLEX-USA Level 1. Includes high-yield systems-based content review, Osteopathic Principles and Practice (OPP), pathology, pharmacology, microbiology, biochemistry, biostatistics, ethics, and integrated clinical reasoning. Features board-style practice questions with fully explained answers to enhance diagnostic thinking, strengthen weak areas, and improve COMSAE performance.

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Institution
Osteopathic Medicine
Course
Osteopathic Medicine

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ALL THE COMSAE WITH ACCURATE
ANSWERS AND EXPLANATIONS


drug for UC/Crohns - correct answer.💖💖💖💖✔<<<<<sulfasalazine



pulmonary effects of CF - correct answer.💖💖💖💖✔<<<<<chronic bronchitis an dbronchiectasis



osteoporosis affects what parts of bone? - correct answer.💖💖💖💖✔<<<<<(spongy and )
trabecular bone mass loss



imipramine - correct answer.💖💖💖💖✔<<<<<TCA



SE: Tri-Cs

convulsions

coma

cardiotox



antichol effects- confusion in elderly; (acute glaucoma and orthostatic hypotension- block alpha1)



viscerosomatic - correct answer.💖💖💖💖✔<<<<<visceral disease --> somatic finding



loratidine vs ranitidine - correct answer.💖💖💖💖✔<<<<<loratidine: 2nd gen H1 blocker, doesnt
cross BBB --> less sedating



ranitidine: H2 receptor antagonist (like cimetidine)



cells w RBCs inside - correct answer.💖💖💖💖✔<<<<<entaemoba histolytica

,which type of pneumothorax causes tracheal deviation to the contra side? - correct
answer.💖💖💖💖✔<<<<<tension



intracerebral hemorrhage adjacent to a lesion that contains a tangle of numerous tortuous vessels -
correct answer.💖💖💖💖✔<<<<<AVM arteriovenous malformation



cavernous hemangioma - correct answer.💖💖💖💖✔<<<<<benign tumor of liver, A/W VHL



anti-HepB surface antibody is only present in what pop - correct
answer.💖💖💖💖✔<<<<<recovered or immunized



not in chronic or



proctalgia fugax - correct answer.💖💖💖💖✔<<<<<levator ani syndrome



fasciculus is UMN or LMN lesion? - correct answer.💖💖💖💖✔<<<<<LMN



ectopic gastric tissue - correct answer.💖💖💖💖✔<<<<<meckels diverticulum



can also have ectopic pancreatic tissue



remnant of vitelline duct



antibodies in hashimotos attacks - correct answer.💖💖💖💖✔<<<<<thyroid peroxidase or
antithyroglobulin



enlarged non tender thyroid



2 factors that influence starling curve - correct answer.💖💖💖💖✔<<<<<x axis- preload (EDV)

,y axis- stroke volume or CO



treatment for fibromyalgia - correct answer.💖💖💖💖✔<<<<<TCA, SNRIs anticonvulsants



what blocks NE reuptake? - correct answer.💖💖💖💖✔<<<<<TCA or SNRIs



possible complication of pagets bone disease - correct answer.💖💖💖💖✔<<<<<osteocarcoma



what does Hct tell you? - correct answer.💖💖💖💖✔<<<<<ratio of volume of RBCs compared to
total blood volume



probenecid - correct answer.💖💖💖💖✔<<<<<inhibits reabsoprtion of uric acid in PCT

- also inhibits secretion of PCN

- can ppt uric acid calculi



2 causes of SCID - correct answer.💖💖💖💖✔<<<<<ADA deficiency

(adenosine deaminase required for degradation of adenosim and deoxyadenosine

- in ADA deficiency, high levels of dATP --> toxicity in lymphocytes --> SCID



hypoplastic thymus



lithiums effects on urination - correct answer.💖💖💖💖✔<<<<<inhibits vasopression/ADH -->
increased urinary frequency



infertility drug that can result in multiple fetuses - correct answer.💖💖💖💖✔<<<<<clomiphene
(clones- multiple babies)



antagonist at estrogen R in hypothalamus (thus inhibits normal negative feedback)

, upregulates LH and FSH release from pituitary --> ovulation



used to treat PCOS but can cause ovarian enlargement, multiple fetuses



AFP levels in down syndrome - correct answer.💖💖💖💖✔<<<<<low



GI malformation A/W down syndrome - correct answer.💖💖💖💖✔<<<<<Hirschprungs- congenital
aganglionic megacolon



defective relaxation and peristalsis of rectum and distal sigmoid colon



failure to pass meconium, empty rectal vault, megacolon



myasthenia gravis associations - correct answer.💖💖💖💖✔<<<<<thymoma, thymic hyperplasia



ptosis, diplopia, can affect chewing, swallowing, speaking, shoulders, respiration



tx for tinea - correct answer.💖💖💖💖✔<<<<<azoles



beta blockers for asthma - correct answer.💖💖💖💖✔<<<<<none- even beta 1s can be
nonselective at higher doses



what kind of teratogenic effects are seen w ACE/ARBs - correct answer.💖💖💖💖✔<<<<<fetal
renal agenesis



stones bones groans moans psych overtones - correct answer.💖💖💖💖✔<<<<<high Ca or PTH



PTH is made by what cells? - correct answer.💖💖💖💖✔<<<<<chief cells of parathyroid gland

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Institution
Osteopathic Medicine
Course
Osteopathic Medicine

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Uploaded on
February 25, 2026
Number of pages
78
Written in
2025/2026
Type
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