what dose is delivered in phase I prostate treatment? what is this field meant to treat?
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-treat whole pelvis to include regional Lymph nodes at risk (high risk
patients)
-45Gy in 25 fractions
what is the natural history of disease progression for prostate cancer?
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, -most are multifocal and develop in the peripheral glands of the prostate
-it is slow growing disease
-as the tumor grows it may extend into and through the capsule of the
gland, invade per prostatic tissue and the seminal vesicles. tumor may
invade the perineural space, lymphatics ad blood vessels or can
metastasize to LN and blood vessels to other parts of the body
what are the two strongest prognostic indicators for prostate cancer?
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-clinical stage
-grade of tumor differentiation
others include age, race, prostate specific antigen level, lymph node status
stage groupings for prostate cancer
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stage I = T1a-T2a N0 M0
stage II = T2b-2c N0 M0
stage III = T3 N0 M0
stage IV = T4 N0 M0, any T, N1 M0, ant T, any N M1
when is hormone therapy used for prostate cancer?
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, as a neoadjuvant therapy
Gleason score
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-obtained by examining the histologic architecture of the biopsy
-summative score of two values
-two scores ranging from 1-5 are given for the primary and secondary
grade of the tissue obtained by biopsy
-gleason score can therefore range from 2-10
-1= well differentiated 5= poorly differentiated
what are the routes of spread for prostate cancer?
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-local spread: outside of prostatic capsule, seminal vesicles, bladder,
rectum
-lymph nodes: periporstatic, obturator, ecternal iliac, hypogastric, common
iliac, para-aortic
-hematogenous: bone
LHRH
Give this one a try later!
Give this one a try later!
-treat whole pelvis to include regional Lymph nodes at risk (high risk
patients)
-45Gy in 25 fractions
what is the natural history of disease progression for prostate cancer?
Give this one a try later!
, -most are multifocal and develop in the peripheral glands of the prostate
-it is slow growing disease
-as the tumor grows it may extend into and through the capsule of the
gland, invade per prostatic tissue and the seminal vesicles. tumor may
invade the perineural space, lymphatics ad blood vessels or can
metastasize to LN and blood vessels to other parts of the body
what are the two strongest prognostic indicators for prostate cancer?
Give this one a try later!
-clinical stage
-grade of tumor differentiation
others include age, race, prostate specific antigen level, lymph node status
stage groupings for prostate cancer
Give this one a try later!
stage I = T1a-T2a N0 M0
stage II = T2b-2c N0 M0
stage III = T3 N0 M0
stage IV = T4 N0 M0, any T, N1 M0, ant T, any N M1
when is hormone therapy used for prostate cancer?
Give this one a try later!
, as a neoadjuvant therapy
Gleason score
Give this one a try later!
-obtained by examining the histologic architecture of the biopsy
-summative score of two values
-two scores ranging from 1-5 are given for the primary and secondary
grade of the tissue obtained by biopsy
-gleason score can therefore range from 2-10
-1= well differentiated 5= poorly differentiated
what are the routes of spread for prostate cancer?
Give this one a try later!
-local spread: outside of prostatic capsule, seminal vesicles, bladder,
rectum
-lymph nodes: periporstatic, obturator, ecternal iliac, hypogastric, common
iliac, para-aortic
-hematogenous: bone
LHRH
Give this one a try later!
