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BPS 2110 Questions Midterm 2 Questions
and Correct Answers/ Latest Update /
Already Graded
What is Lipinski's Rule of Five?
Ans: A guideline used in drug discovery to predict the
likelihood of poor absorption or permeation based on specific
molecular properties.
What are the criteria for a compound to be poorly absorbed according
to Lipinski's Rule of Five?
Ans: More than 5 hydrogen bond donors, more than 10
hydrogen bond acceptors, molecular weight greater than 500,
or calculated LogP greater than 5.
What are hydrogen bond donors and acceptors in the context of
Lipinski's Rule?
Ans: Donors are functional groups containing -OH or -NH,
while acceptors are nitrogen and oxygen atoms with lone pairs
of electrons.
How does molecular weight affect drug absorption?
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Ans: Larger molecules tend to be less soluble and cross
membranes less easily due to size preventing diffusion through
lipid bilayers.
What is lipophilicity and why is it important for drugs?
Ans: Lipophilicity refers to a compound's affinity for lipids;
effective drugs must balance lipophilicity and hydroph ilicity to
dissolve in biological fluids and cross membranes.
What is LogP?
Ans: The logarithm of the partition coefficient between
octanol and water for the neutral form of a drug, indicating its
lipophilicity.
What is LogD and how does it differ from LogP?
Ans: LogD is the partition coefficient at a specific pH, relevant
for ionizable compounds, while LogP is measured under non -
physiological conditions.
What are the two common methods to measure LogP?
Ans: Shake-Flask method and High-Performance Liquid
Chromatography (HPLC).
All rights reserved © 2025/ 2026 |
BPS 2110 Questions Midterm 2 Questions
and Correct Answers/ Latest Update /
Already Graded
What is Lipinski's Rule of Five?
Ans: A guideline used in drug discovery to predict the
likelihood of poor absorption or permeation based on specific
molecular properties.
What are the criteria for a compound to be poorly absorbed according
to Lipinski's Rule of Five?
Ans: More than 5 hydrogen bond donors, more than 10
hydrogen bond acceptors, molecular weight greater than 500,
or calculated LogP greater than 5.
What are hydrogen bond donors and acceptors in the context of
Lipinski's Rule?
Ans: Donors are functional groups containing -OH or -NH,
while acceptors are nitrogen and oxygen atoms with lone pairs
of electrons.
How does molecular weight affect drug absorption?
All rights reserved © 2025/ 2026 |
, Page |2
Ans: Larger molecules tend to be less soluble and cross
membranes less easily due to size preventing diffusion through
lipid bilayers.
What is lipophilicity and why is it important for drugs?
Ans: Lipophilicity refers to a compound's affinity for lipids;
effective drugs must balance lipophilicity and hydroph ilicity to
dissolve in biological fluids and cross membranes.
What is LogP?
Ans: The logarithm of the partition coefficient between
octanol and water for the neutral form of a drug, indicating its
lipophilicity.
What is LogD and how does it differ from LogP?
Ans: LogD is the partition coefficient at a specific pH, relevant
for ionizable compounds, while LogP is measured under non -
physiological conditions.
What are the two common methods to measure LogP?
Ans: Shake-Flask method and High-Performance Liquid
Chromatography (HPLC).
All rights reserved © 2025/ 2026 |
