1
NURS 660 Psychopharmacology Exam 1
Questions and Answers A+ Guaranteed
1. Adverse response of alpha 1 adrenergic receptors in aripiprazole - ANSWER
Dizziness, sedation, hypotension
2. Drug interactions with aripiprazole - ANSWER Ketoconazole, enhance
hypertensives
3. Aripiprazole warning - ANSWER Impulsivity
4. Clozapine use - ANSWER Treatment-resistant schizophrenia, schizophrenia
associated with suicidality
5. Clozapine monitoring parameters - ANSWER ANC >1500 u/L, BEN - ANC
>1000 u/L
6. Purpose of ANC monitoring with Clozapine treatment - ANSWER
Agranulocytosis
7. What niche symptoms does Clozapine treat? - ANSWER Aggression and
violence
8. What is the first atypical antipsychotic? - ANSWER Clozapine
9. What is an awakening after starting Clozapine? - ANSWER Response of a
return to near normal along with improvement of positive symptoms, hope
for cure
10.What antipsychotic has been proven to reduce the risk of suicide? -
ANSWER Clozapine
11.Clozapine induced myocarditis-causes & monitoring - ANSWER
Hypersensitivity reaction, occurs in first 4 weeks, Troponin and C-reactive
protein at initiation and weekly for first 4 weeks
, 2
12.What antipsychotic has the greatest risk of life threatening complications? -
ANSWER Clozapine
13.Clozapine - ANSWER A medication used to treat schizophrenia.
14.Clozapine side effects - ANSWER Side effects: NEUROLEPTIC
MALIGNANT SYNDROME, sedation, salivation, dizzy, H/A, tremors,
sleep problems, akinesia, fever, seizures, confusion, insomnia, slurred
speech, dystonia, tachycardia, hypo/hypertension, blurred vision, drooling,
constipation, abd pain, N/V/D weight gain, dry mouth, urinary
abnormalities, leukopenia, agranulocytosis, rigidity, diaphoresis, death
(demented geriatrics).
15.Agranulocytosis - ANSWER A potentially severe side effect of certain
medications, characterized by a dangerously low level of neutrophils.
16.Aripiprazole use - ANSWER Used for schizophrenia, bipolar disorder,
major depressive disorder, and irritability associated with autism in
children/adolescents (6-17).
17.Clozapine MOA - ANSWER Dual dopamine and serotonin regulation,
moderate for D2 and potent for 5HT2A.
18.Mesocortical dopamine pathway - ANSWER Group of dopaminergic axons
that originates in the VTA and travels to the cerebral cortex, including the
prefrontal, cingulated, and entorhinal cortices. It may also be called the
mesocortical tract.
19.Characteristics of typical (FGA) antipsychotics - ANSWER Only works on
D2 receptors, D2 antagonist, very effective on positive symptoms, EPS side
effects, increase in negative symptoms if too much.
20.Neurolepsis - ANSWER D2 receptors are blocked in mesolimbic pathway
reduces positive symptoms of schizophrenia, block reward mechanism,
leaving patients apathetic, anhedonic, lacking motivation, interest and joy
from social interactions, state similar to negative symptoms of
schizophrenia.
21.Neurotransmitters involved in schizophrenia - ANSWER Dopamine,
serotonin, GABA, glutamate.
, 3
22.Parkinsonism treatment - ANSWER Amantadine or Levodopa.
23.Parkinsonism: caused by - ANSWER An imbalance of neurotransmitters
dopamine and acetylcholine.
24.Which dopamine pathway is most strongly associated with positive
symptoms of schizophrenia? - ANSWER Mesolimbic
25.Which brain region is linked to flat affect, avolition, and alogia in
schizophrenia? - ANSWER Dorsolateral prefrontal cortex
26.Which neurotransmitter hypothesis explains cognitive deficits in
schizophrenia? - ANSWER NMDA receptor hypofunction
27.What feature distinguishes atypical from conventional antipsychotics? -
ANSWER 5HT2A antagonism
28.What adverse effect results from dopamine blockade in the nigrostriatal
pathway? - ANSWER Extrapyramidal symptoms
29.Which antipsychotic is associated with agranulocytosis requiring ANC
monitoring? - ANSWER Clozapine
30.Which receptor is associated with antipsychotic-induced weight gain? -
ANSWER H1
31.Dopamine blockade in which pathway causes galactorrhea and amenorrhea?
- ANSWER Tuberoinfundibular
32.Which antipsychotic is preferred for patients with schizophrenia and a
history of severe EPS? - ANSWER Quetiapine
33.What mechanism reduces EPS risk in serotonin-dopamine antagonists? -
ANSWER Increased dopamine release in nigrostriatal pathway
34.Which symptoms are considered negative symptoms of schizophrenia? -
ANSWER Flat affect, Avolition, Alogia
NURS 660 Psychopharmacology Exam 1
Questions and Answers A+ Guaranteed
1. Adverse response of alpha 1 adrenergic receptors in aripiprazole - ANSWER
Dizziness, sedation, hypotension
2. Drug interactions with aripiprazole - ANSWER Ketoconazole, enhance
hypertensives
3. Aripiprazole warning - ANSWER Impulsivity
4. Clozapine use - ANSWER Treatment-resistant schizophrenia, schizophrenia
associated with suicidality
5. Clozapine monitoring parameters - ANSWER ANC >1500 u/L, BEN - ANC
>1000 u/L
6. Purpose of ANC monitoring with Clozapine treatment - ANSWER
Agranulocytosis
7. What niche symptoms does Clozapine treat? - ANSWER Aggression and
violence
8. What is the first atypical antipsychotic? - ANSWER Clozapine
9. What is an awakening after starting Clozapine? - ANSWER Response of a
return to near normal along with improvement of positive symptoms, hope
for cure
10.What antipsychotic has been proven to reduce the risk of suicide? -
ANSWER Clozapine
11.Clozapine induced myocarditis-causes & monitoring - ANSWER
Hypersensitivity reaction, occurs in first 4 weeks, Troponin and C-reactive
protein at initiation and weekly for first 4 weeks
, 2
12.What antipsychotic has the greatest risk of life threatening complications? -
ANSWER Clozapine
13.Clozapine - ANSWER A medication used to treat schizophrenia.
14.Clozapine side effects - ANSWER Side effects: NEUROLEPTIC
MALIGNANT SYNDROME, sedation, salivation, dizzy, H/A, tremors,
sleep problems, akinesia, fever, seizures, confusion, insomnia, slurred
speech, dystonia, tachycardia, hypo/hypertension, blurred vision, drooling,
constipation, abd pain, N/V/D weight gain, dry mouth, urinary
abnormalities, leukopenia, agranulocytosis, rigidity, diaphoresis, death
(demented geriatrics).
15.Agranulocytosis - ANSWER A potentially severe side effect of certain
medications, characterized by a dangerously low level of neutrophils.
16.Aripiprazole use - ANSWER Used for schizophrenia, bipolar disorder,
major depressive disorder, and irritability associated with autism in
children/adolescents (6-17).
17.Clozapine MOA - ANSWER Dual dopamine and serotonin regulation,
moderate for D2 and potent for 5HT2A.
18.Mesocortical dopamine pathway - ANSWER Group of dopaminergic axons
that originates in the VTA and travels to the cerebral cortex, including the
prefrontal, cingulated, and entorhinal cortices. It may also be called the
mesocortical tract.
19.Characteristics of typical (FGA) antipsychotics - ANSWER Only works on
D2 receptors, D2 antagonist, very effective on positive symptoms, EPS side
effects, increase in negative symptoms if too much.
20.Neurolepsis - ANSWER D2 receptors are blocked in mesolimbic pathway
reduces positive symptoms of schizophrenia, block reward mechanism,
leaving patients apathetic, anhedonic, lacking motivation, interest and joy
from social interactions, state similar to negative symptoms of
schizophrenia.
21.Neurotransmitters involved in schizophrenia - ANSWER Dopamine,
serotonin, GABA, glutamate.
, 3
22.Parkinsonism treatment - ANSWER Amantadine or Levodopa.
23.Parkinsonism: caused by - ANSWER An imbalance of neurotransmitters
dopamine and acetylcholine.
24.Which dopamine pathway is most strongly associated with positive
symptoms of schizophrenia? - ANSWER Mesolimbic
25.Which brain region is linked to flat affect, avolition, and alogia in
schizophrenia? - ANSWER Dorsolateral prefrontal cortex
26.Which neurotransmitter hypothesis explains cognitive deficits in
schizophrenia? - ANSWER NMDA receptor hypofunction
27.What feature distinguishes atypical from conventional antipsychotics? -
ANSWER 5HT2A antagonism
28.What adverse effect results from dopamine blockade in the nigrostriatal
pathway? - ANSWER Extrapyramidal symptoms
29.Which antipsychotic is associated with agranulocytosis requiring ANC
monitoring? - ANSWER Clozapine
30.Which receptor is associated with antipsychotic-induced weight gain? -
ANSWER H1
31.Dopamine blockade in which pathway causes galactorrhea and amenorrhea?
- ANSWER Tuberoinfundibular
32.Which antipsychotic is preferred for patients with schizophrenia and a
history of severe EPS? - ANSWER Quetiapine
33.What mechanism reduces EPS risk in serotonin-dopamine antagonists? -
ANSWER Increased dopamine release in nigrostriatal pathway
34.Which symptoms are considered negative symptoms of schizophrenia? -
ANSWER Flat affect, Avolition, Alogia
