NBME 13 Exam Questions and
Answers 100% PASS
What strucuture attaches to the cervical region and extends posteriorly—ANSWER-
Uterosacral ligament
A 54 y/o woman comes to the physician because of a 5-day history of severe mid-back pain
Physical examination shows point tenderness over the T6 vertebra. Serum studies show a
calcium concentration of 13.4 mg/dl; urinalysis shows Bence Jones proteins. Which of the
following is the most likely cause of this patient's hyper-calcemia?—ANSWER-Local
interleukin-1 and tumor necrosis factor
Chronic mal-absoprtion + retinal degeneration + ataxia + motor dysfunction + low
cholesterol—ANSWER-Abetalipoproteinemia;
Apo B-100 def
Exposure to paint thinner + Dilated pupils + vomiting, confusion, difficultly walking—
ANSWER-Formaldehyde dehydrogenase
Which of the following structures can be cut to decrease stomach acid output and decrease
likelihood of ulcers forming in jejunum—ANSWER-Vagal trunks
Sequence analysis of mitochondrial DNA shows a mutation in 50% of the mothers
mitochondria DNA and in 100% of each other children's mitochondrial DNA. A pedigree is
,shown. Which of the following genetic principles best explains the findings in this family?—
ANSWER-Heteroplasmy
A 52 year old man with a family history of renal failure comest to the physician because of
abdominal pain over the last 6 months. He has been treated in the past for renal calculi and
hypertension. Physical examination shows bilateral palpable masses in the upper abdomen.
Urinalysis shows crenated erythrocytes and mild proteinuria. A CT scan of the abdomen
identifies the cause of the patient's problem. Which of the following is the most likely
diagnosis?—ANSWER-Polycystic Kidney Disease
Previously healthy 6 y/o girl presents with abdominal pain + nausea + vomiting 4 hours after
attending a friends birthday party; What is the cause of these findings?—ANSWER-
Enterotoxin ingestion
A 39-year-old woman with end-stage renal disease caused by systemic lupus erythernatosus
undergoes kidney transplantation from a living, unrelated donor. Despite aggressive
immunosuppressive therapy, the transplant is rejected after 6 months. Analysis of a biopsy
specimen of the transplant shows numerous infiltrating CD8+ T lymphocytes. Which of the
following is the most likely cause of rejection of the transplant in this patient?—ANSWER-
Direct cytotoxicity
A male newborn is delivered at 38 weeks' gestation following an uncomplicated pregnancy.
Twelve-hours later, he begins sucking frantically and crying inconsolably. He overreacts to
stimuli around him and has a marked startle response. The symptoms slowly resolve over
the next 2 to 3 weeks. The most likely explanation for these symptoms is maternal use of
which of the following substances during pregnancy?—ANSWER-Herion
© 2026 Copyright. All Rights Reserved. This document is
protected by copyright law, Copyrighted By Brittie Donald
, A 22-year-old woman comes to the physician for a follow-up examination. One year ago, she
was diagnosed with a pulmonary embolism. Two years ago, she delivered a female stillborn
at 23 weeks' gestation. Physical examination today shows no abnormalities. Laboratory
studies show a platelet count of 250,000/mm3, a prothrombin time within the reference
range, and an increased partial thromboplastin time. The findings in this patient are most
consistent with which of the following conditions?—ANSWER-Antiphospholipid syndrome
A 36-year-old man comes to the physician for a routine examination. He has a 5-year history
of recurrent episodes of genital herpes treated with acyclovir. He says, "I`ve been taking the
medication, but I still occasionally get lesions. When will I be cured?" The physician informs
him that herpes simplex is a lifelong infection, with no cure at the present time. Which of
the following best explains the longevity of the herpes simplex virus?—ANSWER-
Establishment of a latent infection in sensory nerve cells
A mouse melanoma, B-16. is highly metastatic. A clone of the B-16 melanoma cells is
injected intravenously into the tail vein of mice, and 3 weeks later tumor nodules are found
in the lungs, liver, and ovaries. When an antibody to a liver cell surface antigen is injected 1
hour prior to injection of the B-16 melanoma cells, formation of tumor nodules in the liver is
prevented, but tumor nodules develop in the ovaries and lungs. In vitro studies do not show
any cytotoxic effect of the antibody on B-16 or hepatic cells. Which of the following
processes is most likely to be affected by the antibody?—ANSWER-Homing
A study is conducted to assess the effectiveness of vitamin C in preventing common colds in
children, Patients are randomly assigned to receive either vitamin C or no intervention.
Outcome events (common cold) are reported by the parents on a monthly basis for 1 year.
Results show that those taking vitamin C have fewer colds compared with those who
Answers 100% PASS
What strucuture attaches to the cervical region and extends posteriorly—ANSWER-
Uterosacral ligament
A 54 y/o woman comes to the physician because of a 5-day history of severe mid-back pain
Physical examination shows point tenderness over the T6 vertebra. Serum studies show a
calcium concentration of 13.4 mg/dl; urinalysis shows Bence Jones proteins. Which of the
following is the most likely cause of this patient's hyper-calcemia?—ANSWER-Local
interleukin-1 and tumor necrosis factor
Chronic mal-absoprtion + retinal degeneration + ataxia + motor dysfunction + low
cholesterol—ANSWER-Abetalipoproteinemia;
Apo B-100 def
Exposure to paint thinner + Dilated pupils + vomiting, confusion, difficultly walking—
ANSWER-Formaldehyde dehydrogenase
Which of the following structures can be cut to decrease stomach acid output and decrease
likelihood of ulcers forming in jejunum—ANSWER-Vagal trunks
Sequence analysis of mitochondrial DNA shows a mutation in 50% of the mothers
mitochondria DNA and in 100% of each other children's mitochondrial DNA. A pedigree is
,shown. Which of the following genetic principles best explains the findings in this family?—
ANSWER-Heteroplasmy
A 52 year old man with a family history of renal failure comest to the physician because of
abdominal pain over the last 6 months. He has been treated in the past for renal calculi and
hypertension. Physical examination shows bilateral palpable masses in the upper abdomen.
Urinalysis shows crenated erythrocytes and mild proteinuria. A CT scan of the abdomen
identifies the cause of the patient's problem. Which of the following is the most likely
diagnosis?—ANSWER-Polycystic Kidney Disease
Previously healthy 6 y/o girl presents with abdominal pain + nausea + vomiting 4 hours after
attending a friends birthday party; What is the cause of these findings?—ANSWER-
Enterotoxin ingestion
A 39-year-old woman with end-stage renal disease caused by systemic lupus erythernatosus
undergoes kidney transplantation from a living, unrelated donor. Despite aggressive
immunosuppressive therapy, the transplant is rejected after 6 months. Analysis of a biopsy
specimen of the transplant shows numerous infiltrating CD8+ T lymphocytes. Which of the
following is the most likely cause of rejection of the transplant in this patient?—ANSWER-
Direct cytotoxicity
A male newborn is delivered at 38 weeks' gestation following an uncomplicated pregnancy.
Twelve-hours later, he begins sucking frantically and crying inconsolably. He overreacts to
stimuli around him and has a marked startle response. The symptoms slowly resolve over
the next 2 to 3 weeks. The most likely explanation for these symptoms is maternal use of
which of the following substances during pregnancy?—ANSWER-Herion
© 2026 Copyright. All Rights Reserved. This document is
protected by copyright law, Copyrighted By Brittie Donald
, A 22-year-old woman comes to the physician for a follow-up examination. One year ago, she
was diagnosed with a pulmonary embolism. Two years ago, she delivered a female stillborn
at 23 weeks' gestation. Physical examination today shows no abnormalities. Laboratory
studies show a platelet count of 250,000/mm3, a prothrombin time within the reference
range, and an increased partial thromboplastin time. The findings in this patient are most
consistent with which of the following conditions?—ANSWER-Antiphospholipid syndrome
A 36-year-old man comes to the physician for a routine examination. He has a 5-year history
of recurrent episodes of genital herpes treated with acyclovir. He says, "I`ve been taking the
medication, but I still occasionally get lesions. When will I be cured?" The physician informs
him that herpes simplex is a lifelong infection, with no cure at the present time. Which of
the following best explains the longevity of the herpes simplex virus?—ANSWER-
Establishment of a latent infection in sensory nerve cells
A mouse melanoma, B-16. is highly metastatic. A clone of the B-16 melanoma cells is
injected intravenously into the tail vein of mice, and 3 weeks later tumor nodules are found
in the lungs, liver, and ovaries. When an antibody to a liver cell surface antigen is injected 1
hour prior to injection of the B-16 melanoma cells, formation of tumor nodules in the liver is
prevented, but tumor nodules develop in the ovaries and lungs. In vitro studies do not show
any cytotoxic effect of the antibody on B-16 or hepatic cells. Which of the following
processes is most likely to be affected by the antibody?—ANSWER-Homing
A study is conducted to assess the effectiveness of vitamin C in preventing common colds in
children, Patients are randomly assigned to receive either vitamin C or no intervention.
Outcome events (common cold) are reported by the parents on a monthly basis for 1 year.
Results show that those taking vitamin C have fewer colds compared with those who
