NBME - NEW TESTS QUESTIONS
AND ANSWERS 100% PASS
62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected beneficial
effect of the drug is due to which of the following?—ANSWER-Decreased Osteoclast Activity
Cohot Study of elderly women – relative risk ratio for hip fractures among those who
exercise regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the
conclusion about the effect of exercise on the risk of hip fracture?—ANSWER-Statistically
Significant Overall Increase Risk
52 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is
80/min and blood pressure is 130/70. The most immediate treatment mechanism of
action?—ANSWER-Increased nitric oxide concentration
24 year old woman – spilled hot grease on her left leg while working at a fast-food
restaurant. Exam of leg shows 7cm pink, soft, granular, edematous wound. The formation of
this tissue was most likely caused by increased activity of which?—ANSWER-a. Vascular
Endothelial Growth Factor
VEGF – stimulates angiogenesiss.
,TYPE III Collagen = Blood Vessels – early wound repair
27 year old man- MVC – skull x-ray shows a linear, nondepressed basal skull fracture –
increased serum osm and decreased urin osm. Following desmopressin urine osm increases.
Desmopressin’s effect is due to the activation of which of the following?—ANSWER-a.
Adenylyl Cyclase
Adenylate Cyclase – ATP – CAMP -- PROTEKINASE A -- Ca
v2
A 10 month old boy – 4 day history of fever and cough. He attends day care center. Chest
exam shows intercostal retractions along with bilateral, diffuse wheezes and expiratory
rhonchi. The infectious agent most likely has which of the following properties?—ANSWER-
Mediation of Cell Entry via a fusion protein
A 17 year old girl in ED – 15 minutes after being stung by a bee. Mild light headedness but
no difficulty swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy
for this patient?—ANSWER-B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week
of fatigue. He recentaly had sex with one partner. Physical exam show cervical
lymphadenopathy and pharyngeal erythema with a creamy exudate. DX?—ANSWER-
Infectious Mononucleosis
© 2026 Copyright. All Rights Reserved. This document is
protected by copyright law, Copyrighted By Brittie Donald
, 57 year old man – radiation therapy for squamous cell carcinoma of the lung. Despite
therapy, tumor increases in size and he dies 6 months later. The progressive tumor growth is
due to a defect in cell cycle arrest in which of the following phases of cell cycle?—ANSWER-
G1
28 year old – lived in sub-Saharan Africa – until he came to the US. Temp of 100.4 – imaging
shows bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered
granulomas. DX?—ANSWER-Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has
two gene deletion. If the two gene is trans – what percentage of offspring will have a two
gene deletion?—ANSWER-50%
previously healthy 40 year brought to emergency department by her husband – 2 day
history of fever, lethargy, confusion. PE shows scattered petechiae and ecchymoses over the
lower extremities – 3+ polychromasia and 3+ schistocytes and Low platelets Dx?—ANSWER-
Thrombotic Thrombocytopenia Purpura
16 year old boy – is admitted to the ER because of a knife wound to the left side of his chest.
An X-ray of the chest shows an air-fluid level in the left side of the chest, partial collapse of
the left lung, and the elevation of the stomach bubble. The mediastinum is midline. DX?—
ANSWER-Hemopneumpothorax under tension
49 year old woman – coronary artery disease – BP 140/90 - High Cholesterol, High LDL (190),
High triglycerides (350) – TX with atorvastatin and losartan. What are the effects on HDL and
Triglycerides?—ANSWER-HDL increased
AND ANSWERS 100% PASS
62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected beneficial
effect of the drug is due to which of the following?—ANSWER-Decreased Osteoclast Activity
Cohot Study of elderly women – relative risk ratio for hip fractures among those who
exercise regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the
conclusion about the effect of exercise on the risk of hip fracture?—ANSWER-Statistically
Significant Overall Increase Risk
52 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is
80/min and blood pressure is 130/70. The most immediate treatment mechanism of
action?—ANSWER-Increased nitric oxide concentration
24 year old woman – spilled hot grease on her left leg while working at a fast-food
restaurant. Exam of leg shows 7cm pink, soft, granular, edematous wound. The formation of
this tissue was most likely caused by increased activity of which?—ANSWER-a. Vascular
Endothelial Growth Factor
VEGF – stimulates angiogenesiss.
,TYPE III Collagen = Blood Vessels – early wound repair
27 year old man- MVC – skull x-ray shows a linear, nondepressed basal skull fracture –
increased serum osm and decreased urin osm. Following desmopressin urine osm increases.
Desmopressin’s effect is due to the activation of which of the following?—ANSWER-a.
Adenylyl Cyclase
Adenylate Cyclase – ATP – CAMP -- PROTEKINASE A -- Ca
v2
A 10 month old boy – 4 day history of fever and cough. He attends day care center. Chest
exam shows intercostal retractions along with bilateral, diffuse wheezes and expiratory
rhonchi. The infectious agent most likely has which of the following properties?—ANSWER-
Mediation of Cell Entry via a fusion protein
A 17 year old girl in ED – 15 minutes after being stung by a bee. Mild light headedness but
no difficulty swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy
for this patient?—ANSWER-B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week
of fatigue. He recentaly had sex with one partner. Physical exam show cervical
lymphadenopathy and pharyngeal erythema with a creamy exudate. DX?—ANSWER-
Infectious Mononucleosis
© 2026 Copyright. All Rights Reserved. This document is
protected by copyright law, Copyrighted By Brittie Donald
, 57 year old man – radiation therapy for squamous cell carcinoma of the lung. Despite
therapy, tumor increases in size and he dies 6 months later. The progressive tumor growth is
due to a defect in cell cycle arrest in which of the following phases of cell cycle?—ANSWER-
G1
28 year old – lived in sub-Saharan Africa – until he came to the US. Temp of 100.4 – imaging
shows bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered
granulomas. DX?—ANSWER-Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has
two gene deletion. If the two gene is trans – what percentage of offspring will have a two
gene deletion?—ANSWER-50%
previously healthy 40 year brought to emergency department by her husband – 2 day
history of fever, lethargy, confusion. PE shows scattered petechiae and ecchymoses over the
lower extremities – 3+ polychromasia and 3+ schistocytes and Low platelets Dx?—ANSWER-
Thrombotic Thrombocytopenia Purpura
16 year old boy – is admitted to the ER because of a knife wound to the left side of his chest.
An X-ray of the chest shows an air-fluid level in the left side of the chest, partial collapse of
the left lung, and the elevation of the stomach bubble. The mediastinum is midline. DX?—
ANSWER-Hemopneumpothorax under tension
49 year old woman – coronary artery disease – BP 140/90 - High Cholesterol, High LDL (190),
High triglycerides (350) – TX with atorvastatin and losartan. What are the effects on HDL and
Triglycerides?—ANSWER-HDL increased
