COMLEX-USA Practice Exam
1. A 30-year-old male presents with acute onset severe
right lower quadrant abdominal pain, nausea, and
low-grade fever. Most likely diagnosis?
A. Cholecystitis
B. Appendicitis
C. Diverticulitis
D. Kidney stone
Answer: B. Appendicitis
Rationale: Acute RLQ pain, nausea, and low-grade
fever in a young adult is classic for appendicitis;
McBurney’s point tenderness is typical.
, 2. Osteopathic philosophy emphasizes:
A. Treating only the symptoms
B. Holistic patient care including body, mind, and spirit
C. Exclusive reliance on surgery
D. Ignoring musculoskeletal contributions
Answer: B. Holistic patient care including body, mind,
and spirit
Rationale: Osteopathic medicine emphasizes treating
the whole person, not just disease.
3. Mechanism of action of loop diuretics?
A. Inhibit Na+/Cl– symporter in distal convoluted tubule
B. Inhibit Na+/K+/2Cl– cotransporter in thick ascending
loop of Henle
C. Antagonize aldosterone
D. Block aquaporin channels
Answer: B. Inhibit Na+/K+/2Cl– cotransporter in
thick ascending loop of Henle
Rationale: Loop diuretics block Na+/K+/2Cl–
cotransporter, causing significant diuresis.
4. First-line therapy for osteoarthritis of the knee?
1. A 30-year-old male presents with acute onset severe
right lower quadrant abdominal pain, nausea, and
low-grade fever. Most likely diagnosis?
A. Cholecystitis
B. Appendicitis
C. Diverticulitis
D. Kidney stone
Answer: B. Appendicitis
Rationale: Acute RLQ pain, nausea, and low-grade
fever in a young adult is classic for appendicitis;
McBurney’s point tenderness is typical.
, 2. Osteopathic philosophy emphasizes:
A. Treating only the symptoms
B. Holistic patient care including body, mind, and spirit
C. Exclusive reliance on surgery
D. Ignoring musculoskeletal contributions
Answer: B. Holistic patient care including body, mind,
and spirit
Rationale: Osteopathic medicine emphasizes treating
the whole person, not just disease.
3. Mechanism of action of loop diuretics?
A. Inhibit Na+/Cl– symporter in distal convoluted tubule
B. Inhibit Na+/K+/2Cl– cotransporter in thick ascending
loop of Henle
C. Antagonize aldosterone
D. Block aquaporin channels
Answer: B. Inhibit Na+/K+/2Cl– cotransporter in
thick ascending loop of Henle
Rationale: Loop diuretics block Na+/K+/2Cl–
cotransporter, causing significant diuresis.
4. First-line therapy for osteoarthritis of the knee?
