1
NAPLEX 2026 OVERVIEW Questions
and Answers (100% Correct
Answers) Already Graded A+
Acetaminophen Ans: BN: Tylenol
© 2026 Assignment
Can cause hepatotoxicity
Guru01 - Stuvia
Max dose <4000 mg/day
Expert
N-acetylcysteine (NAC) antidote for overdose
Acetaminophen + Hydrocodone Ans: BN: Lorcet, Lortab,
Norco, Vicodin
Acetaminophen + Oxycodone Ans: BN: Endocet, Percoset
Acetaminophen + Codeine Ans: BN: Tylenol #2, 3, 4
Acetaminophen + Tramadol Ans: BN: Ultracet
Acetaminophen + Caffeine Ans: BN: Excedrin Tension
Headache
Acetaminophen + Caffeine + Pyrilamine Ans: BN: Midol
Ibuprofen Ans: BN: Advil, Motrin
NSAID
, 2
Indomethacin Ans: BN: Indocin
NSAID
Naproxen Ans: BN: Aleve, Naprosyn
NSAID
Ketorolac Ans: BN: Toradol
© 2026 Assignment
NSAID
Guru01 - Stuvia
BBW: max combined duration (IV/IM/PO) is 5 days.
Expert
Celecoxib Ans: BN: Celebrex
NSAID
CI: sulfonamide allergy
Highest COX-2 selectivity (lower risk for GI complications but
increase risk for stroke/MI
Diclofenac Ans: BN: Voltaren
NSAID with increased COX-2 selectivity
- Gel: upper body do not exceed 8 grams/day, lower body do
not exceed 16 grams/day.
Meloxicam Ans: BN: Mobic
NSAID with increased COX-2 selectivity
, 3
Aspirin Ans: BN: Bayer aspirin
avoid in children and teens with viral infection due to
potential risk of Reye's syndrome.
used in ASCVD risk and for the prevention of colorectal CA
NSAID DDI Ans: - additive bleeding risk
- caution with ototoxic agents (aminoglycosides, IV loop
© 2026 Assignment
diuretics
Guru01 - Stuvia
- can increase levels of lithium and methotrexate
Expert
Codiene Ans: Opioid
- BBW: same as all opioids + do not use in children <12 and <18
following tonsillectomy/adenoidectomy
- Prodrug for morphine and metabolized by 2D6
Fentanyl Ans: BN: Duragesic, Sublimaze
Opioid
- Not for use in opioid naïve patients (need to be on morphine
60 mg/day or equivalent for at least 7 days.
Hydrocodone Ans: BN: Norco (IR), (ER: Zohydro, Hysingla)
opioid
Hydromorphone Ans: BN: Dilaudid, Exalgo
, 4
Opioid
Methadone Ans: BN: Dolophine, Methadose
Opioid
BBW: same as all opioids + life threatening QT prolongation
and serious arrhythmias.
warning; MAOI's and serotonic drugs can increase the risk of
© 2026 Assignment
serotonin syndrome.
Guru01 - Stuvia
Major 3A4 substrate
Expert
Merperidine Ans: BN: Demerol
Opioid
Warning: renal impairment/elderly at risk for CNS toxicity.
Avoid with or within 2 weeks of an MAOI
No longer recommended as an analgesic agent
Morphine Ans: BN: (ER: MS Contin, Kadian) (Injection:
Duramorph, Infumorph)
Opioid
Can give diphenhydramine if pruritus occurs.
Oxycodone Ans: BN: Roxicodone, Oxycontin, Xtampza
Opioid
NAPLEX 2026 OVERVIEW Questions
and Answers (100% Correct
Answers) Already Graded A+
Acetaminophen Ans: BN: Tylenol
© 2026 Assignment
Can cause hepatotoxicity
Guru01 - Stuvia
Max dose <4000 mg/day
Expert
N-acetylcysteine (NAC) antidote for overdose
Acetaminophen + Hydrocodone Ans: BN: Lorcet, Lortab,
Norco, Vicodin
Acetaminophen + Oxycodone Ans: BN: Endocet, Percoset
Acetaminophen + Codeine Ans: BN: Tylenol #2, 3, 4
Acetaminophen + Tramadol Ans: BN: Ultracet
Acetaminophen + Caffeine Ans: BN: Excedrin Tension
Headache
Acetaminophen + Caffeine + Pyrilamine Ans: BN: Midol
Ibuprofen Ans: BN: Advil, Motrin
NSAID
, 2
Indomethacin Ans: BN: Indocin
NSAID
Naproxen Ans: BN: Aleve, Naprosyn
NSAID
Ketorolac Ans: BN: Toradol
© 2026 Assignment
NSAID
Guru01 - Stuvia
BBW: max combined duration (IV/IM/PO) is 5 days.
Expert
Celecoxib Ans: BN: Celebrex
NSAID
CI: sulfonamide allergy
Highest COX-2 selectivity (lower risk for GI complications but
increase risk for stroke/MI
Diclofenac Ans: BN: Voltaren
NSAID with increased COX-2 selectivity
- Gel: upper body do not exceed 8 grams/day, lower body do
not exceed 16 grams/day.
Meloxicam Ans: BN: Mobic
NSAID with increased COX-2 selectivity
, 3
Aspirin Ans: BN: Bayer aspirin
avoid in children and teens with viral infection due to
potential risk of Reye's syndrome.
used in ASCVD risk and for the prevention of colorectal CA
NSAID DDI Ans: - additive bleeding risk
- caution with ototoxic agents (aminoglycosides, IV loop
© 2026 Assignment
diuretics
Guru01 - Stuvia
- can increase levels of lithium and methotrexate
Expert
Codiene Ans: Opioid
- BBW: same as all opioids + do not use in children <12 and <18
following tonsillectomy/adenoidectomy
- Prodrug for morphine and metabolized by 2D6
Fentanyl Ans: BN: Duragesic, Sublimaze
Opioid
- Not for use in opioid naïve patients (need to be on morphine
60 mg/day or equivalent for at least 7 days.
Hydrocodone Ans: BN: Norco (IR), (ER: Zohydro, Hysingla)
opioid
Hydromorphone Ans: BN: Dilaudid, Exalgo
, 4
Opioid
Methadone Ans: BN: Dolophine, Methadose
Opioid
BBW: same as all opioids + life threatening QT prolongation
and serious arrhythmias.
warning; MAOI's and serotonic drugs can increase the risk of
© 2026 Assignment
serotonin syndrome.
Guru01 - Stuvia
Major 3A4 substrate
Expert
Merperidine Ans: BN: Demerol
Opioid
Warning: renal impairment/elderly at risk for CNS toxicity.
Avoid with or within 2 weeks of an MAOI
No longer recommended as an analgesic agent
Morphine Ans: BN: (ER: MS Contin, Kadian) (Injection:
Duramorph, Infumorph)
Opioid
Can give diphenhydramine if pruritus occurs.
Oxycodone Ans: BN: Roxicodone, Oxycontin, Xtampza
Opioid
