1
Fungal infections Part 1 & 2
Questions and Answers (100%
Correct Answers) Already Graded A+
Candidiasis Ans: - yeast that causes most fungal infections
© 2026 Assignment
- normal in GI, vagina, mouth, mucocutaneous borders
Guru01 - Stuvia
- skin rarely conlizines but may be on "moist" damaged skin
Expert
Candidiasis: natural immunity Ans: 1st line of defense:
phagocytes
2nd line: T cells
increased risk if:
- immunosuppressed
- neutropenic
- ABX disruption of normal flora
Candidiasis: dx definitive Ans: no gold standard
Definitive:
- culture of organism from tissue
, 2
- endophthalmitis
- burn wound
- peritonitis
Candidiasis: dx likely to be infected but not necessarily
infected ? Ans: - 2 positive blood cultures >24h apart w/out
central line
© 2026 Assignment
- 2 positive blood cultures w/ a second > 24 h after removal of
central line
Guru01 - Stuvia
Expert
- 3 or more colonized sites w/ supporting evidence of systemic
infection
generally just treat
Mucocutaneous candidiasis Ans: - thrush (oropharyngeal)
- esophageal: painful (aids/corticosteroids)
- GI (mucositis & inflammation)
- vaginal
Oral candidiasis tx Ans: Local:
- clotrimazole troches
- nystatin
Oral:
, 3
- fluconazole
- itraconazole
- AMP B dissolved in solution
Esophageal candidiasis tx Ans: - more severe, pain,
potentially feels like MI
- seen in immunocomp
© 2026 Assignment
HIV: fluconazole resistance occurs due to chronic use for
Guru01 - Stuvia
prevention
Expert
- if refractory use echinocandin or AMP B
- not common if HIV is controlled
Candida vaginitis Ans: - caused by C. Albicans
- tx w/ topical azole or oral Fluconazole
- Refractory: common in immunocomp
- tx w/ combo topical polyene, boric acid
Candida vaginitis: pregnancy Ans: common
- teratogenicity can occur w/ oral so use topical
- musculoskeletal malformations (rare)
- increase dose, increased risk
Fungal infections Part 1 & 2
Questions and Answers (100%
Correct Answers) Already Graded A+
Candidiasis Ans: - yeast that causes most fungal infections
© 2026 Assignment
- normal in GI, vagina, mouth, mucocutaneous borders
Guru01 - Stuvia
- skin rarely conlizines but may be on "moist" damaged skin
Expert
Candidiasis: natural immunity Ans: 1st line of defense:
phagocytes
2nd line: T cells
increased risk if:
- immunosuppressed
- neutropenic
- ABX disruption of normal flora
Candidiasis: dx definitive Ans: no gold standard
Definitive:
- culture of organism from tissue
, 2
- endophthalmitis
- burn wound
- peritonitis
Candidiasis: dx likely to be infected but not necessarily
infected ? Ans: - 2 positive blood cultures >24h apart w/out
central line
© 2026 Assignment
- 2 positive blood cultures w/ a second > 24 h after removal of
central line
Guru01 - Stuvia
Expert
- 3 or more colonized sites w/ supporting evidence of systemic
infection
generally just treat
Mucocutaneous candidiasis Ans: - thrush (oropharyngeal)
- esophageal: painful (aids/corticosteroids)
- GI (mucositis & inflammation)
- vaginal
Oral candidiasis tx Ans: Local:
- clotrimazole troches
- nystatin
Oral:
, 3
- fluconazole
- itraconazole
- AMP B dissolved in solution
Esophageal candidiasis tx Ans: - more severe, pain,
potentially feels like MI
- seen in immunocomp
© 2026 Assignment
HIV: fluconazole resistance occurs due to chronic use for
Guru01 - Stuvia
prevention
Expert
- if refractory use echinocandin or AMP B
- not common if HIV is controlled
Candida vaginitis Ans: - caused by C. Albicans
- tx w/ topical azole or oral Fluconazole
- Refractory: common in immunocomp
- tx w/ combo topical polyene, boric acid
Candida vaginitis: pregnancy Ans: common
- teratogenicity can occur w/ oral so use topical
- musculoskeletal malformations (rare)
- increase dose, increased risk
