Ache Practice Exam | Ache Exam Prep 2026/2027
Complete Questions And 100% Correct Answers
| Verified | Graded A+ | Guaranteed Pass!!!
Which of the following is the most important determinant of an allergic drug
reaction?
The genetic pedigree of the patient
The oral bioavailability of the drug
The chemical structure of the drug
The liver and kidney functions of the patient
The dose of the drug - ANSWER-Answer: The chemical structure of the
drug
Some drugs cause allergic reactions very rarely while other compounds
(obviously not used as drugs) can cause sensitization in all exposed
subjects. Therefore the drug structure is the major determinant of the
frequency of an allergic reaction to a drug.
,A) Even if in some rare occurrence the dose can be a factor predisposing to
allergy (i.e penicillin-induced hemolytic anemia requires high and sustained
drug concentrations) the occurrence and the seriousness of an allergic
reaction is not dose-dependent, in most cases.
C) The bioavailability refer to the fraction of the drug reaching the general
circulation. Since allergy is not related to dose, bioavailability is not an
important factor for an allergic drug reaction. Moreover the oral route
carried the lowest risk of allergic reaction.
D) The genetic pedigree is important for idiosyncratic drug
reactions.
E) The patient's liver and kidney functions are important factors for drug
overdose toxicity.
, Question 5
pts
Haptens are usually small molecules that are not immunogenic by
themselves. However they can be bound covalently to a carrier protein and
the hapten-carrier conjugate can induce antibody against the hapten.
A) An allergic reaction is not genetically determined.
B) Storage of a drug into specific reservoirs has nothing to do with an
allergic reaction.
D) The hapten-carrier conjugate acts as antigen.
E) Blockade of specific immunogenic receptors would hinder, not cause,
the allergic reaction.
Complete Questions And 100% Correct Answers
| Verified | Graded A+ | Guaranteed Pass!!!
Which of the following is the most important determinant of an allergic drug
reaction?
The genetic pedigree of the patient
The oral bioavailability of the drug
The chemical structure of the drug
The liver and kidney functions of the patient
The dose of the drug - ANSWER-Answer: The chemical structure of the
drug
Some drugs cause allergic reactions very rarely while other compounds
(obviously not used as drugs) can cause sensitization in all exposed
subjects. Therefore the drug structure is the major determinant of the
frequency of an allergic reaction to a drug.
,A) Even if in some rare occurrence the dose can be a factor predisposing to
allergy (i.e penicillin-induced hemolytic anemia requires high and sustained
drug concentrations) the occurrence and the seriousness of an allergic
reaction is not dose-dependent, in most cases.
C) The bioavailability refer to the fraction of the drug reaching the general
circulation. Since allergy is not related to dose, bioavailability is not an
important factor for an allergic drug reaction. Moreover the oral route
carried the lowest risk of allergic reaction.
D) The genetic pedigree is important for idiosyncratic drug
reactions.
E) The patient's liver and kidney functions are important factors for drug
overdose toxicity.
, Question 5
pts
Haptens are usually small molecules that are not immunogenic by
themselves. However they can be bound covalently to a carrier protein and
the hapten-carrier conjugate can induce antibody against the hapten.
A) An allergic reaction is not genetically determined.
B) Storage of a drug into specific reservoirs has nothing to do with an
allergic reaction.
D) The hapten-carrier conjugate acts as antigen.
E) Blockade of specific immunogenic receptors would hinder, not cause,
the allergic reaction.
