learning objectives
·
steps in platelet activation as
drug targets
· mechanism of action of selected antiplatelet drugs
·
explain ,
with reference to the fibrinolytic system the M .
O . A of fibrinolytic drugs
,
When are antiplatelet drugs used ? where do antiplatelet drugs act ?
·
act on platelet plug formation in
primary haemostasis
plaque
and causes focus on arterial thrombus
ruptures
clot can t I
heart attack
atillgroa
embolize
platelet adhesion leads to platelet aggregation
· This process maybe :
Physiological , pathological
Y released
here
from
injury lead to
aggregation (endothelial damage)
↓
can
negative
effect of
aggregation
Cox inhibitors -
Aspirin
· irreversible inhibitor of Cox-1
halt
· will
profoundly reduce (caSt.) ,
but not
completely platelet aggregation
antiplatelet effect achieved lower dose than that used for
· at a CAS
mg a
day)
analgesic/anti inflammatory effects
used in
·
thromboprophylaxis
Recommended in cases patients experienced a cardiovascular event (e g heart attack .
survivors
·
steps in platelet activation as
drug targets
· mechanism of action of selected antiplatelet drugs
·
explain ,
with reference to the fibrinolytic system the M .
O . A of fibrinolytic drugs
,
When are antiplatelet drugs used ? where do antiplatelet drugs act ?
·
act on platelet plug formation in
primary haemostasis
plaque
and causes focus on arterial thrombus
ruptures
clot can t I
heart attack
atillgroa
embolize
platelet adhesion leads to platelet aggregation
· This process maybe :
Physiological , pathological
Y released
here
from
injury lead to
aggregation (endothelial damage)
↓
can
negative
effect of
aggregation
Cox inhibitors -
Aspirin
· irreversible inhibitor of Cox-1
halt
· will
profoundly reduce (caSt.) ,
but not
completely platelet aggregation
antiplatelet effect achieved lower dose than that used for
· at a CAS
mg a
day)
analgesic/anti inflammatory effects
used in
·
thromboprophylaxis
Recommended in cases patients experienced a cardiovascular event (e g heart attack .
survivors
