Immunohematology Final Exam Questions With Complete
Solutions
8. You have added reagent antibody of the suspected in vivo
antibody to the patient's RBCs. What type of reaction do you
expect and why?
a. Negative reaction because you don't make an antibody to an
antigen that you have
b. Positive reaction because what happens in vivo happens in
vitro
c. Negative reaction because you need to add donor cells to get a
positive reaction
d. Positive reaction because the reagent antibody is an IgM
Correct Answers a. Negative reaction because you don't make
an antibody to an antigen that you have
A D negative mom delivers a D positive infant. The infant is not
exhibiting any HDFN and their DAT is negative. She has no
active anti-D present in her blood and the fetal screen (rosette
test) is negative. What should be done next?
a. Perform the Kleihauer-Betke test
b. Wait a few days and retest
c. Nothing. All is well.
d. Administer 1 dose of Rhogam Correct Answers d.
Administer 1 dose of Rhogam
A mother, 30 weeks pregnant, has anti-K with a titer of 32. An
intrauterine RBC transfusion is indicated. The donor unit should
be all of the following except which one?
a. O negative
b. K negative
,c. Hemoglobin S positive
d. Irradiated Correct Answers c. Hemoglobin S positive
A patient developed a combination of Rh antibodies: anti-C,
anti-E, and anti-D. Can compatible blood be found for this
patient?
a. It is almost impossible to find blood lacking C, E, and D
antigens
b. rr blood could be used without causing a problem
c. RoRo may be used because it lacks all three antigens
d. Although rare, R2r blood may be obtained from close
relatives of the patient Correct Answers b. rr blood could be
used without causing a problem
A patient has a history of anti-Jka. The antibody screen is
currently negative. Which RBC unit should be selected and what
type of crossmatch should be performed?
a. Jk(a-) RBCs, computer crossmatch
b. Jka(-) RBCs, immediate spin crossmatch
c. Jk(a-) RBCs, antiglobulin crossmatch
d. ABO compatible because the antibody screen is negative
Correct Answers c. Jk(a-) RBCs, antiglobulin crossmatch
A patient who previously typed as AB is now typing as follows:
anti-A = 4+, anti-B = 4+, A1 cells = 4+, B cells = 4+, O cells =
4+. Which of the following would not be helpful in determining
the cause of the patient's true blood type?
a. Check age of patient
b. Wash RBCs several times
c. Test with anti-H lectin
d. Pre-warm technique Correct Answers a. Check age of patient
,A patient with weak D has been identified as having C in trans
to D. What type blood would be the best choice for this patient?
a. They should be given D negative blood because they may
make an anti-D
b. They may receive D positive blood
c. They should be given autologous blood
d. They should be given rr blood only Correct Answers b. They
may receive D positive blood
A physician orders 2 units of RBCs. The patient is a 55-year-old
male with anemia. He types as AB negative, and he has not been
previously transfused or formed any antibodies. There is only 1
unit of AB negative in your inventory. What is the next blood
type that should be given?
a. AB positive (patient is a male)
b. A negative
c. B negative
d. O negativ Correct Answers b. A negative
A rosette test on a maternal blood sample is positive. The
Kleihauer-Betke test determines that there has been 65 mls of
fetal maternal hemorrhage. What is the minimum does of
Rhogram that you should administer?
a. 3
b. 1
c. 4
d. 2 Correct Answers a. 3
A shift to the right of the hemoglobin-oxygen dissociation curve
would occur in which of the following conditions?
, a. Shock
b. Hypophosphatemia
c. Normal basal metabolic rate
d. Anemia Correct Answers d. Anemia
A unit of blood is collected into a collection bag with CPDA-1
and after the plasma is expressed AS-1 is added. What is the
shelf life of the packed RBCs?
a. 21 days
b. 35 days
c. 42 days
d. 45 days Correct Answers c. 42 days
A unit of red cells must be transfused within what time frame?
a. 150 minutes
b. 1 hour
c. 4 hours
d. 120 minutes Correct Answers c. 4 hours
ABO HDFN most often occurs in white mothers of what blood
type carrying babies of what blood type?
a. Type O mom carrying type A baby
b. Type B mom carrying type A baby
c. Type A mom carrying type B baby
d. Type O mom carrying type AB baby Correct Answers a.
Type O mom carrying type A baby
After a clerical check which of the following would NOT be
part of the typical tier one (immediate) lab testing in a suspected
transfusion reaction?
a. Perform DAT
Solutions
8. You have added reagent antibody of the suspected in vivo
antibody to the patient's RBCs. What type of reaction do you
expect and why?
a. Negative reaction because you don't make an antibody to an
antigen that you have
b. Positive reaction because what happens in vivo happens in
vitro
c. Negative reaction because you need to add donor cells to get a
positive reaction
d. Positive reaction because the reagent antibody is an IgM
Correct Answers a. Negative reaction because you don't make
an antibody to an antigen that you have
A D negative mom delivers a D positive infant. The infant is not
exhibiting any HDFN and their DAT is negative. She has no
active anti-D present in her blood and the fetal screen (rosette
test) is negative. What should be done next?
a. Perform the Kleihauer-Betke test
b. Wait a few days and retest
c. Nothing. All is well.
d. Administer 1 dose of Rhogam Correct Answers d.
Administer 1 dose of Rhogam
A mother, 30 weeks pregnant, has anti-K with a titer of 32. An
intrauterine RBC transfusion is indicated. The donor unit should
be all of the following except which one?
a. O negative
b. K negative
,c. Hemoglobin S positive
d. Irradiated Correct Answers c. Hemoglobin S positive
A patient developed a combination of Rh antibodies: anti-C,
anti-E, and anti-D. Can compatible blood be found for this
patient?
a. It is almost impossible to find blood lacking C, E, and D
antigens
b. rr blood could be used without causing a problem
c. RoRo may be used because it lacks all three antigens
d. Although rare, R2r blood may be obtained from close
relatives of the patient Correct Answers b. rr blood could be
used without causing a problem
A patient has a history of anti-Jka. The antibody screen is
currently negative. Which RBC unit should be selected and what
type of crossmatch should be performed?
a. Jk(a-) RBCs, computer crossmatch
b. Jka(-) RBCs, immediate spin crossmatch
c. Jk(a-) RBCs, antiglobulin crossmatch
d. ABO compatible because the antibody screen is negative
Correct Answers c. Jk(a-) RBCs, antiglobulin crossmatch
A patient who previously typed as AB is now typing as follows:
anti-A = 4+, anti-B = 4+, A1 cells = 4+, B cells = 4+, O cells =
4+. Which of the following would not be helpful in determining
the cause of the patient's true blood type?
a. Check age of patient
b. Wash RBCs several times
c. Test with anti-H lectin
d. Pre-warm technique Correct Answers a. Check age of patient
,A patient with weak D has been identified as having C in trans
to D. What type blood would be the best choice for this patient?
a. They should be given D negative blood because they may
make an anti-D
b. They may receive D positive blood
c. They should be given autologous blood
d. They should be given rr blood only Correct Answers b. They
may receive D positive blood
A physician orders 2 units of RBCs. The patient is a 55-year-old
male with anemia. He types as AB negative, and he has not been
previously transfused or formed any antibodies. There is only 1
unit of AB negative in your inventory. What is the next blood
type that should be given?
a. AB positive (patient is a male)
b. A negative
c. B negative
d. O negativ Correct Answers b. A negative
A rosette test on a maternal blood sample is positive. The
Kleihauer-Betke test determines that there has been 65 mls of
fetal maternal hemorrhage. What is the minimum does of
Rhogram that you should administer?
a. 3
b. 1
c. 4
d. 2 Correct Answers a. 3
A shift to the right of the hemoglobin-oxygen dissociation curve
would occur in which of the following conditions?
, a. Shock
b. Hypophosphatemia
c. Normal basal metabolic rate
d. Anemia Correct Answers d. Anemia
A unit of blood is collected into a collection bag with CPDA-1
and after the plasma is expressed AS-1 is added. What is the
shelf life of the packed RBCs?
a. 21 days
b. 35 days
c. 42 days
d. 45 days Correct Answers c. 42 days
A unit of red cells must be transfused within what time frame?
a. 150 minutes
b. 1 hour
c. 4 hours
d. 120 minutes Correct Answers c. 4 hours
ABO HDFN most often occurs in white mothers of what blood
type carrying babies of what blood type?
a. Type O mom carrying type A baby
b. Type B mom carrying type A baby
c. Type A mom carrying type B baby
d. Type O mom carrying type AB baby Correct Answers a.
Type O mom carrying type A baby
After a clerical check which of the following would NOT be
part of the typical tier one (immediate) lab testing in a suspected
transfusion reaction?
a. Perform DAT
