Goodman and Gilman's The
Pharmacological Basis of Therapeutics
14th Edition
• Author(s)Laurence Brunton; Bjorn
Knollmann
(Goodman & Gilman–Only | Exam-Ready |
Nursing-Focused)
Goodman & Gilman’s The Pharmacological Basis of
Therapeutics, 14th Edition
Chapter 1: Drug Discovery: From Medicinal Plants to
Computer-Aided Drug Design
Nursing Pharmacology Test Bank
,Chapter 1 – Drug Discovery
EXACTLY 20 Exam-Ready MCQs
1.
Which historical source most directly contributed to the
earliest identification of pharmacologically active compounds?
A. Randomized clinical trials
B. Synthetic chemistry libraries
C. Traditional use of medicinal plants
D. High-throughput screening platforms
Correct Answer: C
Rationale:
The chapter emphasizes that many early drugs originated from
empirical observations of medicinal plants used in traditional
medicine.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
2.
Which characteristic best distinguishes a “lead compound” in
drug discovery?
A. It is already approved for clinical use
B. It demonstrates desired biological activity but requires
,optimization
C. It has maximal selectivity and minimal toxicity
D. It has completed Phase III trials
Correct Answer: B
Rationale:
A lead compound shows promising biological activity but
typically requires chemical modification to improve efficacy,
selectivity, or safety.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
3.
Which process involves modifying a lead compound to
improve potency or reduce toxicity?
A. Pharmacovigilance
B. Lead optimization
C. Post-marketing surveillance
D. Bioequivalence testing
Correct Answer: B
Rationale:
Lead optimization refers to systematic chemical modification
of lead compounds to improve pharmacologic properties.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
, 4.
Which drug discovery approach relies on knowledge of the
molecular structure of a biological target?
A. Phenotypic screening
B. Serendipitous discovery
C. Structure-based drug design
D. Ethnopharmacology
Correct Answer: C
Rationale:
Structure-based drug design uses the three-dimensional
structure of targets such as receptors or enzymes to design
ligands.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
5.
Which term describes the interaction between a drug
candidate and its molecular target?
A. Pharmacokinetics
B. Pharmacodynamics
C. Bioavailability
D. Metabolism
Pharmacological Basis of Therapeutics
14th Edition
• Author(s)Laurence Brunton; Bjorn
Knollmann
(Goodman & Gilman–Only | Exam-Ready |
Nursing-Focused)
Goodman & Gilman’s The Pharmacological Basis of
Therapeutics, 14th Edition
Chapter 1: Drug Discovery: From Medicinal Plants to
Computer-Aided Drug Design
Nursing Pharmacology Test Bank
,Chapter 1 – Drug Discovery
EXACTLY 20 Exam-Ready MCQs
1.
Which historical source most directly contributed to the
earliest identification of pharmacologically active compounds?
A. Randomized clinical trials
B. Synthetic chemistry libraries
C. Traditional use of medicinal plants
D. High-throughput screening platforms
Correct Answer: C
Rationale:
The chapter emphasizes that many early drugs originated from
empirical observations of medicinal plants used in traditional
medicine.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
2.
Which characteristic best distinguishes a “lead compound” in
drug discovery?
A. It is already approved for clinical use
B. It demonstrates desired biological activity but requires
,optimization
C. It has maximal selectivity and minimal toxicity
D. It has completed Phase III trials
Correct Answer: B
Rationale:
A lead compound shows promising biological activity but
typically requires chemical modification to improve efficacy,
selectivity, or safety.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
3.
Which process involves modifying a lead compound to
improve potency or reduce toxicity?
A. Pharmacovigilance
B. Lead optimization
C. Post-marketing surveillance
D. Bioequivalence testing
Correct Answer: B
Rationale:
Lead optimization refers to systematic chemical modification
of lead compounds to improve pharmacologic properties.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
, 4.
Which drug discovery approach relies on knowledge of the
molecular structure of a biological target?
A. Phenotypic screening
B. Serendipitous discovery
C. Structure-based drug design
D. Ethnopharmacology
Correct Answer: C
Rationale:
Structure-based drug design uses the three-dimensional
structure of targets such as receptors or enzymes to design
ligands.
Citation: Goodman & Gilman, 14th ed., Chapter 1 – Drug
Discovery
5.
Which term describes the interaction between a drug
candidate and its molecular target?
A. Pharmacokinetics
B. Pharmacodynamics
C. Bioavailability
D. Metabolism
