Final exam question bank_fall - A Grade

Final exam question bank_ Page 1 of 36 In matching questions each lettered heading may be selected once, more than once, or not at all. 1. All of the following are true about organ transplantation except: A. Identical twins can usually accept grafts from one another B. A xenograft is one that comes from a different species C. Hyperacute rejection can be mediated by antibodies D. Persons who are MHC identical will give a high level of DNA synthesis in a MLR E. A second allograft from the same donor will be rejected faster than the first one Questions Indicate which of the types of specific immunity would be most effective for protection against 2. intravesicular bacteria. A. T-cell mediated macrophage activation B. CD8 T-cells (cytotoxic T-cells) C. Neutralization by IgG D. Neutralization by IgA E. Opsonization by antibody 3. virus that lands on mucous membrane 4. Virus replicating within host cell 5. Viral particles released into the bloodstream 6. extracellular pathogens that resist ingestion by phagocytes. 7. intracellular cytosolic pathogens. 8. toxins secreted into bloodstream 9. Which of the following statements about CD4 and CD 8 T-cells is true A. Both recognize [MHC class 2+peptide] B. Both secrete TCRs C. Both are self-MHC restricted D. CD8 T-cells help B-cells make antibody E. CD4 T-cells require “help” from CD8 T-cells to become activated 10.Which of the following statements about MHC genes/molecules is true A. MHC class 1 will present peptides from a killed viral vaccine B. MHC class 1 genes include DR,DQ,DP C. MHC class 2 has an alpha chain and Beta 2 microglobulin D. MHC class 2 is present on macrophages, dendritic cells and B cells E. Both bind polysaccharide epitopes 11.Which of the following statements about MHC class 1 pathway and MHC class 2 pathway of antigen processing is true A. MHC class 1 pathway involves proteasome digestion of peptides into small fragments B. MHC class 2 pathway uses TAP to bring peptides to endosomes C. Both pathways require CLIP to prevent the loading of self peptides while the MHC molecule remains in the endoplasmic reticulum D. Peptide production in endosomes is involved in both pathways Match the following types of “pathogen” with the major route of MHC processing and presentation that will occur 12.A live extracelluar bacterial pathogen, such as Hemophilus influenzae type b, is phagocytosed by a macrophage 13.A live virus enters its target cell , an epithelial cell, and replicates CHOICES for Q 12-15 14.An inactivated (dead-cannot replicate) virus is phagocytosed by a macrophage A.MHC class 1 pathway B.MHC class 2 pathway 15.A live intracellular bacterial pathogen, such as Mycobacterium avium intracelluare, is phagocytosed by a macrophage