NU 641 Exam 1 Practice Questions and
answers 2026\2027 A+ Grade
Ch 1 Prescriptive Authority 2. Which factors increase the need for APRNs to have full prescriptive
authority?
- correct answer a. More patients will have access to health care.
Ch 1 Prescriptive Authority 3. Which factors could be attributed to limited prescriptive authority for
APRNs? Select all that apply.
- correct answer a. Inaccessibility of patient care
b. Higher health care costs
Ch 1 Prescriptive Authority 4. Which aspects support the APRN's provision for full prescriptive authority?
Select all that apply
- correct answer a. Clinical education includes prescription of medications and disease processes.
c. National examinations provide validation of the APRN's ability to provide safe care.
d. Licensure ensures compliance with health care and safety standards.
Ch 1 Prescriptive Authority 5. Which aspects support the APRN's provision for full prescriptive authority?
Select all that apply.
- correct answer a. Clinical education includes prescription of medications and disease processes.
c. National examinations provide validation of the APRN's ability to provide safe care.
d. Licensure ensures compliance with health care and safety standards.
Ch 1 Prescriptive Authority 6. A family nurse practitioner practicing in Maine is hired at a practice across
state lines in Virginia. Which aspect of practice may change for the APRN?
- correct answer a. The APRN will have less prescriptive authority in the new position.
,Ch 2 Rational Drug Selection and Prescription Writing 7. How can collaboration with a pharmacist
improve positive outcomes for patients? Select all that apply.
- correct answer b. Pharmacists have additional information on drug interactions.
c. The pharmacist can suggest adequate medication dosing.
d. Pharmacists have firsthand knowledge of the facility formulary.
Ch 2 Rational Drug Selection and Prescription Writing 8. A patient presents with delirium tremens
requiring Ativan administration. The provider of care is not in the facility. Which action by the nurse is
most appropriate?
- correct answer a. Obtain a telephone order.
Ch 2 Rational Drug Selection and Prescription Writing 9. A patient with chronic pain calls the provider's
office to request a refill on their oxycontin. Which action is most appropriate?
- correct answer b. Schedule an appointment with the patient.
Ch 2 Rational Drug Selection and Prescription Writing 10. A patient prescribed amoxicillin for
streptococcal pharyngitis reports new onset of a flat, itchy red rash on the chest and neck. Which action
is most important?
- correct answer b. Discontinue the medication.
Ch 2 Rational Drug Selection and Prescription Writing 11. A patient taking three medications for
hypertension is diagnosed with COPD. Which action should be taken prior to prescribing medications to
treat COPD?
- correct answer b. Obtain a complete medication history.
Ch 2 Rational Drug Selection and Prescription Writing 12. A patient with diabetes reports losing their job
and an inability to purchase required medications. Which action is most appropriate?
- correct answer c. Contact a different pharmacy.
Ch 2 Rational Drug Selection and Prescription Writing 13. A patient recently prescribed hydrocodone
calls to report they are unable to fill the prescription. Which factors could contribute to the inability to
fill the prescription? Select all that apply.
- correct answer a. DEA number missing from prescription
b. Prescription sent via electronic messenger
d. Prescriber license number not included
,Ch 3 Promoting Positive Outcomes of Drug Therapy 14. A patient reports that a medication prescribed
for recurrent migraine headaches is not working. Which action should be taken first?
- correct answer a. Ask the patient about the number and frequency of tablets taken.
Ch 3 Promoting Positive Outcomes of Drug Therapy 15. A patient is prescribed metronidazole for
bacterial vaginosis. Which patient history finding would be most concerning?
- correct answer c. Drinks two glasses of wine every night
Ch 3 Promoting Positive Outcomes of Drug Therapy 16. A patient is using a metered-dose inhaler
containing albuterol for asthma. The medication label instructs the patient to administer "two puffs
every 4 hours as needed for coughing or wheezing." The patient reports feeling jittery sometimes when
taking the medication, and she doesn't feel that the medication is always effective. Which action is most
appropriate?
- correct answer c. Auscultating lung sounds and obtaining vital signs
Ch 3 Promoting Positive Outcomes of Drug Therapy 17. A patient newly diagnosed with diabetes is to be
discharged from the hospital. Which action should be taken first during medication education?
- correct answer a. Asking the patient to demonstrate how to measure and administer insulin
Ch 3 Promoting Positive Outcomes of Drug Therapy 18. The drug manual states that older adult patients
are at increased risk for hepatic side effects. Which action is most important when prescribing this
medication to an 80-year-old patient?
- correct answer a. Obtain pretreatment laboratory work.
Ch 3 Promoting Positive Outcomes of Drug Therapy 19. A patient recently diagnosed with HIV is
prescribed several medications to treat the condition. Which factors could impact the patient's
adherence to the treatment regimen? Select all that apply.
- correct answer a. The patient is uninsured
b. The patient works three part-time jobs
c. The medication regimen includes six different pills
e. Medication regimen requires medication be taken at regular 4-hour intervals.
Ch 3 Promoting Positive Outcomes of Drug Therapy 20. A patient diagnosed with bipolar disorder is
prescribed daily lithium. Which action is most important to determine if the therapeutic level is
, maintained?
- correct answer c. Ensure periodic laboratory testing is completed.
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 21. The nurse administers naloxone
[Narcan] to a patient who has received a toxic dose of morphine sulfate. The nurse understands that the
naloxone is effective because of which action?
- correct answer c. Preventing activation of opioid receptors through antagonist actions
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 22. A patient is taking drug X and
receives a new prescription for drug Y, which is listed as an inducing agent. The nurse caring for this
patient understands that this patient may require doses of drug
- correct answer c. higher X
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 23. The nurse is preparing to
administer penicillin G intramuscularly to a child. The child's parents ask why the drug cannot be given in
an oral liquid form. What is the nurse's reply?
- correct answer d. "This drug would be inactivated by enzymes in the stomach."
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 24. Which statement about food and
drug interactions is true?
- correct answer d. Some foods can inhibit CYP isoenzymes and alter drug metabolism.
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 25. A nurse is teaching a patient
about a drug that induces P-glycoprotein. The nurse will explain that this drug may cause which effect
on other drugs?
- correct answer b. Decreased elimination through the kidneys
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 26. A patient claims to get better
effects with a tablet of Brand X of a drug than with a tablet of Brand Y of the same drug. Both brands
contain the same amount of the active ingredient. What does the nurse know to be most likely?
- correct answer c. Tablets can differ in composition and can have differing rates of disintegration and
dissolution, which can alter the drug's effects in the body.
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 27. Two nurses are discussing
theories of drug-receptor interaction. Which statements are true regarding the affinity of a drug and its
receptor?
- correct answer b. Affinity refers to the strength of the attraction between a drug and its receptor.
answers 2026\2027 A+ Grade
Ch 1 Prescriptive Authority 2. Which factors increase the need for APRNs to have full prescriptive
authority?
- correct answer a. More patients will have access to health care.
Ch 1 Prescriptive Authority 3. Which factors could be attributed to limited prescriptive authority for
APRNs? Select all that apply.
- correct answer a. Inaccessibility of patient care
b. Higher health care costs
Ch 1 Prescriptive Authority 4. Which aspects support the APRN's provision for full prescriptive authority?
Select all that apply
- correct answer a. Clinical education includes prescription of medications and disease processes.
c. National examinations provide validation of the APRN's ability to provide safe care.
d. Licensure ensures compliance with health care and safety standards.
Ch 1 Prescriptive Authority 5. Which aspects support the APRN's provision for full prescriptive authority?
Select all that apply.
- correct answer a. Clinical education includes prescription of medications and disease processes.
c. National examinations provide validation of the APRN's ability to provide safe care.
d. Licensure ensures compliance with health care and safety standards.
Ch 1 Prescriptive Authority 6. A family nurse practitioner practicing in Maine is hired at a practice across
state lines in Virginia. Which aspect of practice may change for the APRN?
- correct answer a. The APRN will have less prescriptive authority in the new position.
,Ch 2 Rational Drug Selection and Prescription Writing 7. How can collaboration with a pharmacist
improve positive outcomes for patients? Select all that apply.
- correct answer b. Pharmacists have additional information on drug interactions.
c. The pharmacist can suggest adequate medication dosing.
d. Pharmacists have firsthand knowledge of the facility formulary.
Ch 2 Rational Drug Selection and Prescription Writing 8. A patient presents with delirium tremens
requiring Ativan administration. The provider of care is not in the facility. Which action by the nurse is
most appropriate?
- correct answer a. Obtain a telephone order.
Ch 2 Rational Drug Selection and Prescription Writing 9. A patient with chronic pain calls the provider's
office to request a refill on their oxycontin. Which action is most appropriate?
- correct answer b. Schedule an appointment with the patient.
Ch 2 Rational Drug Selection and Prescription Writing 10. A patient prescribed amoxicillin for
streptococcal pharyngitis reports new onset of a flat, itchy red rash on the chest and neck. Which action
is most important?
- correct answer b. Discontinue the medication.
Ch 2 Rational Drug Selection and Prescription Writing 11. A patient taking three medications for
hypertension is diagnosed with COPD. Which action should be taken prior to prescribing medications to
treat COPD?
- correct answer b. Obtain a complete medication history.
Ch 2 Rational Drug Selection and Prescription Writing 12. A patient with diabetes reports losing their job
and an inability to purchase required medications. Which action is most appropriate?
- correct answer c. Contact a different pharmacy.
Ch 2 Rational Drug Selection and Prescription Writing 13. A patient recently prescribed hydrocodone
calls to report they are unable to fill the prescription. Which factors could contribute to the inability to
fill the prescription? Select all that apply.
- correct answer a. DEA number missing from prescription
b. Prescription sent via electronic messenger
d. Prescriber license number not included
,Ch 3 Promoting Positive Outcomes of Drug Therapy 14. A patient reports that a medication prescribed
for recurrent migraine headaches is not working. Which action should be taken first?
- correct answer a. Ask the patient about the number and frequency of tablets taken.
Ch 3 Promoting Positive Outcomes of Drug Therapy 15. A patient is prescribed metronidazole for
bacterial vaginosis. Which patient history finding would be most concerning?
- correct answer c. Drinks two glasses of wine every night
Ch 3 Promoting Positive Outcomes of Drug Therapy 16. A patient is using a metered-dose inhaler
containing albuterol for asthma. The medication label instructs the patient to administer "two puffs
every 4 hours as needed for coughing or wheezing." The patient reports feeling jittery sometimes when
taking the medication, and she doesn't feel that the medication is always effective. Which action is most
appropriate?
- correct answer c. Auscultating lung sounds and obtaining vital signs
Ch 3 Promoting Positive Outcomes of Drug Therapy 17. A patient newly diagnosed with diabetes is to be
discharged from the hospital. Which action should be taken first during medication education?
- correct answer a. Asking the patient to demonstrate how to measure and administer insulin
Ch 3 Promoting Positive Outcomes of Drug Therapy 18. The drug manual states that older adult patients
are at increased risk for hepatic side effects. Which action is most important when prescribing this
medication to an 80-year-old patient?
- correct answer a. Obtain pretreatment laboratory work.
Ch 3 Promoting Positive Outcomes of Drug Therapy 19. A patient recently diagnosed with HIV is
prescribed several medications to treat the condition. Which factors could impact the patient's
adherence to the treatment regimen? Select all that apply.
- correct answer a. The patient is uninsured
b. The patient works three part-time jobs
c. The medication regimen includes six different pills
e. Medication regimen requires medication be taken at regular 4-hour intervals.
Ch 3 Promoting Positive Outcomes of Drug Therapy 20. A patient diagnosed with bipolar disorder is
prescribed daily lithium. Which action is most important to determine if the therapeutic level is
, maintained?
- correct answer c. Ensure periodic laboratory testing is completed.
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 21. The nurse administers naloxone
[Narcan] to a patient who has received a toxic dose of morphine sulfate. The nurse understands that the
naloxone is effective because of which action?
- correct answer c. Preventing activation of opioid receptors through antagonist actions
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 22. A patient is taking drug X and
receives a new prescription for drug Y, which is listed as an inducing agent. The nurse caring for this
patient understands that this patient may require doses of drug
- correct answer c. higher X
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 23. The nurse is preparing to
administer penicillin G intramuscularly to a child. The child's parents ask why the drug cannot be given in
an oral liquid form. What is the nurse's reply?
- correct answer d. "This drug would be inactivated by enzymes in the stomach."
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 24. Which statement about food and
drug interactions is true?
- correct answer d. Some foods can inhibit CYP isoenzymes and alter drug metabolism.
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 25. A nurse is teaching a patient
about a drug that induces P-glycoprotein. The nurse will explain that this drug may cause which effect
on other drugs?
- correct answer b. Decreased elimination through the kidneys
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 26. A patient claims to get better
effects with a tablet of Brand X of a drug than with a tablet of Brand Y of the same drug. Both brands
contain the same amount of the active ingredient. What does the nurse know to be most likely?
- correct answer c. Tablets can differ in composition and can have differing rates of disintegration and
dissolution, which can alter the drug's effects in the body.
Ch 4 Pharmacokinetics, Pharmacodynamics, and Drug Interactions 27. Two nurses are discussing
theories of drug-receptor interaction. Which statements are true regarding the affinity of a drug and its
receptor?
- correct answer b. Affinity refers to the strength of the attraction between a drug and its receptor.
