EDAPT NCLEX Readiness Exam – Pharmacological & Parenteral
Therapies Part 2: Blood Transfusions, Reactions & Nursing
Interventions |Verified Questions Provided with A+ Graded
Rationales Latest Updated 2026
For each blood transfusion reaction, match the blood transfusion reaction to the prevention
strategy.
Acute hemolytic reaction - Confirm that the blood to be transfused is compatible with the
client's blood type.
Febrile reaction - Consider leukocyte-reduced blood products.
Mild allergic reaction - Consider premedication with diphenhydramine.
Circulatory overload reaction - Adjust transfusion volume and slow the flow rate.
A nurse is caring for a client who is prescribed one unit of packed red blood cells to treat
anemia. Pre-infusion vital signs are T 101.2 °F (38.4 °C), pulse 104, blood pressure 124/76, and
respiratory rate 20. Which action should the nurse take?
Delay starting the transfusion and contact the healthcare provider.
Which items should be checked during the verification process? Select all that apply.
Correct blood product based on the prescription
Expiration date on blood product bag
Client's name and date of birth
After reviewing the electronic health record, which information should be clarified by the
nurse?
Laboratory values
The client asks the nurse which type of packed red blood cells are acceptable for transfusion.
The nurse responds that the client can receive __________ blood products.
O negative
If the nurse were to transfuse O positive blood to a client whose blood type is O negative, the
client is likely to experience a __________ caused by __________.
, Acute hemolytic reaction
RBC destruction
The nurse is providing preoperative education to a client who will undergo a left hip
arthroplasty in 3 weeks. The client asks the nurse if they will need a blood transfusion after the
surgery. Since the client has a very rare blood type, the nurse recommends the client consider
__________.
Elective phlebotomy
The nurse is preparing to administer one unit of packed red blood cells to client and has just
completed the verification process. Place the steps the nurse should take to transfuse the blood
into the correct order.
1. Spike the normal saline bag and prime the Y tubing.
2. Close the clamp that leads to the normal saline bag.
3. Spike the blood bag, open the upper clamp, and allow blood to flow through the tubing.
4. Start the transfusion slowly for 15 minutes.
5. Obtain vital signs and compare them to baseline.
The charge nurse is observing a nurse during orientation who is administering a blood
transfusion. Which action taken by the nurse would require the charge nurse to intervene?
Prepares to administer cefotaxime intravenously in the port closest to the insertion site.
The nurse is caring for several clients who need blood component transfusions. Match the client
to the appropriate component to be transfused.
Packed red blood cells - A client whose hemoglobin and hematocrit are low following a bowel
resection surgery
Fresh frozen plasma - A client with liver disease and a vitamin K deficiency
Platelets - A client who has thrombocytopenia
Albumin - A client who has hypovolemic shock following a motor vehicle accident
Therapies Part 2: Blood Transfusions, Reactions & Nursing
Interventions |Verified Questions Provided with A+ Graded
Rationales Latest Updated 2026
For each blood transfusion reaction, match the blood transfusion reaction to the prevention
strategy.
Acute hemolytic reaction - Confirm that the blood to be transfused is compatible with the
client's blood type.
Febrile reaction - Consider leukocyte-reduced blood products.
Mild allergic reaction - Consider premedication with diphenhydramine.
Circulatory overload reaction - Adjust transfusion volume and slow the flow rate.
A nurse is caring for a client who is prescribed one unit of packed red blood cells to treat
anemia. Pre-infusion vital signs are T 101.2 °F (38.4 °C), pulse 104, blood pressure 124/76, and
respiratory rate 20. Which action should the nurse take?
Delay starting the transfusion and contact the healthcare provider.
Which items should be checked during the verification process? Select all that apply.
Correct blood product based on the prescription
Expiration date on blood product bag
Client's name and date of birth
After reviewing the electronic health record, which information should be clarified by the
nurse?
Laboratory values
The client asks the nurse which type of packed red blood cells are acceptable for transfusion.
The nurse responds that the client can receive __________ blood products.
O negative
If the nurse were to transfuse O positive blood to a client whose blood type is O negative, the
client is likely to experience a __________ caused by __________.
, Acute hemolytic reaction
RBC destruction
The nurse is providing preoperative education to a client who will undergo a left hip
arthroplasty in 3 weeks. The client asks the nurse if they will need a blood transfusion after the
surgery. Since the client has a very rare blood type, the nurse recommends the client consider
__________.
Elective phlebotomy
The nurse is preparing to administer one unit of packed red blood cells to client and has just
completed the verification process. Place the steps the nurse should take to transfuse the blood
into the correct order.
1. Spike the normal saline bag and prime the Y tubing.
2. Close the clamp that leads to the normal saline bag.
3. Spike the blood bag, open the upper clamp, and allow blood to flow through the tubing.
4. Start the transfusion slowly for 15 minutes.
5. Obtain vital signs and compare them to baseline.
The charge nurse is observing a nurse during orientation who is administering a blood
transfusion. Which action taken by the nurse would require the charge nurse to intervene?
Prepares to administer cefotaxime intravenously in the port closest to the insertion site.
The nurse is caring for several clients who need blood component transfusions. Match the client
to the appropriate component to be transfused.
Packed red blood cells - A client whose hemoglobin and hematocrit are low following a bowel
resection surgery
Fresh frozen plasma - A client with liver disease and a vitamin K deficiency
Platelets - A client who has thrombocytopenia
Albumin - A client who has hypovolemic shock following a motor vehicle accident
