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BIOS-252: Anatomy & Physiology II - Examination 1 | Core Domains: Endocrine System (Glands,
Hormones, Mechanisms), Cardiovascular System (Heart Anatomy, Blood Flow, Conduction), Blood
(Components, Hemostasis, Blood Typing), Lymphatic System & Immunity (Innate/Adaptive, Cells,
Organs), and Respiratory System (Anatomy, Mechanics, Gas Exchange) | Anatomy & Physiology
Course Focus | Mid-Course Systems Exam Format
Exam Structure
The BIOS-252 Exam 1 for the 2026/2027 academic cycle is a 75-question, multiple-choice question
(MCQ) examination.
Introduction
This BIOS-252 Exam 1 guide for the 2026/2027 cycle prepares students for the first major assessment in
the second semester of anatomy and physiology. The content focuses on the structure, function, and
integration of the endocrine, cardiovascular, lymphatic/immune, and respiratory systems, emphasizing
homeostatic mechanisms and inter-system relationships.
Answer Format
All correct answers and physiological concepts must be presented in bold and green, followed by
detailed rationales that explain hormone pathways and feedback loops, trace blood flow through the heart
and body, detail immune response mechanisms, and describe the processes of ventilation and gas
exchange.
Questions (75 Total)
1. Which hormone is released by the posterior pituitary and promotes water reabsorption in the kidneys?
A. Aldosterone
B. Antidiuretic hormone (ADH)
C. Cortisol
D. Adrenocorticotropic hormone (ACTH)
Rationale: ADH (vasopressin) is synthesized in the hypothalamus and stored/released from the
posterior pituitary. It increases water permeability in the collecting ducts of the nephron, reducing urine
output and conserving fluid during dehydration or high plasma osmolarity.
2. Blood flows from the right ventricle to the:
A. Pulmonary veins
B. Pulmonary arteries
,C. Aorta
D. Left atrium
Rationale: Deoxygenated blood exits the right ventricle through the pulmonary semilunar valve into
the pulmonary trunk, which branches into left and right pulmonary arteries leading to the lungs for
oxygenation. Pulmonary veins return oxygenated blood to the left atrium.
3. Which blood component is essential for hemostasis?
A. Erythrocytes
B. Platelets
C. Lymphocytes
D. Plasma proteins only
Rationale: Platelets (thrombocytes) are cell fragments that adhere to damaged endothelium,
aggregate to form a plug, and release chemicals that activate the coagulation cascade—critical steps in
hemostasis. Erythrocytes carry oxygen; lymphocytes are involved in immunity.
4. A person with type O negative blood can donate to:
A. Only other type O individuals
B. All blood types (universal donor)
C. Only Rh-negative recipients
D. Type AB positive only
Rationale: Type O negative lacks A, B, and Rh antigens, so it does not trigger agglutination in any
recipient—making it the universal donor for red blood cells. However, type O individuals can only
receive type O blood due to anti-A and anti-B antibodies in their plasma.
5. Which immune cell is responsible for antibody-mediated (humoral) immunity?
A. Cytotoxic T cells
B. B lymphocytes
C. Neutrophils
D. Macrophages
Rationale: B cells mature in the bone marrow and produce antigen-specific antibodies when activated.
Cytotoxic T cells mediate cell-mediated immunity; neutrophils and macrophages are phagocytic cells of
innate immunity.
, 6. During inspiration, the diaphragm:
A. Relaxes and moves upward
B. Contracts and moves downward
C. Remains stationary
D. Expands laterally only
Rationale: Inspiration is an active process. The diaphragm contracts, flattening and moving
inferiorly, while external intercostal muscles lift the rib cage. This increases thoracic volume, decreasing
intrapulmonary pressure and drawing air in.
7. The primary stimulus for erythropoietin (EPO) release is:
A. High blood glucose
B. Low tissue oxygen levels (hypoxia)
C. High calcium levels
D. Increased blood pH
Rationale: EPO is produced by the kidneys in response to hypoxia (e.g., anemia, high altitude). It
stimulates red bone marrow to increase RBC production, enhancing oxygen-carrying capacity and
restoring homeostasis.
8. Which structure prevents backflow of blood from the aorta into the left ventricle?
A. Tricuspid valve
B. Aortic semilunar valve
C. Mitral valve
D. Pulmonary valve
Rationale: The aortic semilunar valve closes when ventricular pressure drops below aortic pressure
during diastole, preventing regurgitation. The mitral (bicuspid) valve guards the left AV junction;
tricuspid is on the right; pulmonary valve is between right ventricle and pulmonary artery.
9. Gas exchange in the alveoli occurs primarily by:
A. Active transport
B. Simple diffusion
C. Osmosis