NUCLEAR MEDICINE UPDATED END OF COURSE
QUESTIONS AND SOLUTIONS GUARANTEE A+
✔✔Diffuse splenic activity greater than that of _______ is consistent with diffuse
lymphomatous infiltration of the spleen. - ✔✔Liver activity.
✔✔Preferred diagnostic modality for melanoma region lymph node involvement -
✔✔Sentinel lymph node mapping.
✔✔Benign causes of distal esophagus PET activity - ✔✔Distal esophagitis. Gastric
reflux. Barrett's esophagus. Hiatal hernia. Retained saliva.
✔✔Tumor activity more than ____ times that of white matter or more than ____ times
that of gray matter has very high sensitivity and specificity for malignancy - ✔✔1.5 times
white matter. 0.6 times gray matter.
✔✔PET features of Alzheimer disease - ✔✔Bilateral hypometabolism of temporal and
parietal lobes. Sparing of visual and motor cortices.
✔✔PET featurs of Pick disease - ✔✔Hypometabolic areas involving both frontal and
anterior temporal lobes.
✔✔PET features of Multi-infarct dementia - ✔✔Multiple defects throughout brain
parenchyma without sparing of visual and motor cortices.
✔✔PET features of Parkinson disease - ✔✔High FDG activity in lentiform nuclei and
thalami related to lack of dopaminergic inhibition. Caudate nuclei are spared.
✔✔PET features of CNS lymphoma versus toxoplasmosis - ✔✔CNS lymphoma is
hypermetabolic. Toxoplasmosis shows little or no FDG activity.
✔✔Low PET Uptake by Malignant Tumors - ✔✔Lobular breast carcinoma. Low-grade
lymphoma. Salivary gland neoplasms. Necrotic primary tumors and lymph nodes.
✔✔ Gallium-67 dose? Gamma energies? Half-life? Time to imaging? - ✔✔5 mCi
(inflam). 10 mCi (tumor). 93, 184, 296, 388 keV. 78 hrs. 6, 24 (inflam). 48-72 (tumor).
✔✔Gallium-67 mechanism of uptake? - ✔✔Fe analog via transferrin.
✔✔Gallium-67 Normal distribution? - ✔✔Liver > spleen, marrow, bone. Variable: breast,
bowel, salivary glands, lacrimal glands.
✔✔I-131 dose? Gamma energies? Half-life? Time to imaging? - ✔✔2 mCi. 364 keV.
half-life 8 days. 48 hrs.
, ✔✔I-131 mechanism of uptake? - ✔✔Iodine. Thyroid uptake,TSH-mediated
✔✔I-131 Normal distribution? - ✔✔Stomach, GI, bladder. Variable: salivary,
nasopharynx,
✔✔I-131 MIBG dose? Gamma energies? Half-life? Time to imaging? - ✔✔2 mCi. 364
keV. 8 days. 48 hrs.
✔✔I-131 MIBG mechanism of uptake? - ✔✔Guanethidine analog. Norepinephrine
reuptake.
✔✔I-131 MIBG normal distribution? - ✔✔Liver > spleen. Variable: salivary, lung, GI,
bladder, skeletal muscle, heart.
✔✔I-123 MIBG dose? Gamma energies? Half-life? Time to imaging? - ✔✔1-10 mCi.
159 keV. 13 hrs. 24 hrs.
✔✔I-123 MIBG normal distribution? - ✔✔Liver > spleen. Variable: salivary, lung, GI,
bladder, skeletal muscle, heart.
✔✔In-111 octreoscan dose? Gamma energies? Half-life? Time to imaging? - ✔✔6 mCi.
172, 247 keV. 67 hrs. 4, 24 hrs.
✔✔Octreoscan mechanism of uptake? - ✔✔Somatostatin analog. Neuroendocrine
tumors.
✔✔In-111 octreoscan normal distribution? - ✔✔Intense renal cortex. Spleen, liver,
pituitary, salivary, GI, bladder. Variable: breast, thyroid.
✔✔FDG-PET dose? Gamma energies? Half-life? Time to imaging? - ✔✔10-15 mCi. 511
keV. 2 hrs. 1 hr.
✔✔FDG-PET mechanism of uptake? - ✔✔Glucose analog. Active transport into cell.
Phosphorylated and trapped.
✔✔FDG-Pet normal distribution - ✔✔Intense urinary activity and cerebral cortex. GU,
liver, spleen, marrow. Variable: thyroid, cardiac, GI, muscle.
✔✔In-111 WBC dose? Gamma energies? Half-life? Time to imaging? - ✔✔0.5 mCi.
172, 247 keV. 67 hrs. 24 hrs.
✔✔In-111 WBC mechanism of uptake? - ✔✔WBC localized at infection.
QUESTIONS AND SOLUTIONS GUARANTEE A+
✔✔Diffuse splenic activity greater than that of _______ is consistent with diffuse
lymphomatous infiltration of the spleen. - ✔✔Liver activity.
✔✔Preferred diagnostic modality for melanoma region lymph node involvement -
✔✔Sentinel lymph node mapping.
✔✔Benign causes of distal esophagus PET activity - ✔✔Distal esophagitis. Gastric
reflux. Barrett's esophagus. Hiatal hernia. Retained saliva.
✔✔Tumor activity more than ____ times that of white matter or more than ____ times
that of gray matter has very high sensitivity and specificity for malignancy - ✔✔1.5 times
white matter. 0.6 times gray matter.
✔✔PET features of Alzheimer disease - ✔✔Bilateral hypometabolism of temporal and
parietal lobes. Sparing of visual and motor cortices.
✔✔PET featurs of Pick disease - ✔✔Hypometabolic areas involving both frontal and
anterior temporal lobes.
✔✔PET features of Multi-infarct dementia - ✔✔Multiple defects throughout brain
parenchyma without sparing of visual and motor cortices.
✔✔PET features of Parkinson disease - ✔✔High FDG activity in lentiform nuclei and
thalami related to lack of dopaminergic inhibition. Caudate nuclei are spared.
✔✔PET features of CNS lymphoma versus toxoplasmosis - ✔✔CNS lymphoma is
hypermetabolic. Toxoplasmosis shows little or no FDG activity.
✔✔Low PET Uptake by Malignant Tumors - ✔✔Lobular breast carcinoma. Low-grade
lymphoma. Salivary gland neoplasms. Necrotic primary tumors and lymph nodes.
✔✔ Gallium-67 dose? Gamma energies? Half-life? Time to imaging? - ✔✔5 mCi
(inflam). 10 mCi (tumor). 93, 184, 296, 388 keV. 78 hrs. 6, 24 (inflam). 48-72 (tumor).
✔✔Gallium-67 mechanism of uptake? - ✔✔Fe analog via transferrin.
✔✔Gallium-67 Normal distribution? - ✔✔Liver > spleen, marrow, bone. Variable: breast,
bowel, salivary glands, lacrimal glands.
✔✔I-131 dose? Gamma energies? Half-life? Time to imaging? - ✔✔2 mCi. 364 keV.
half-life 8 days. 48 hrs.
, ✔✔I-131 mechanism of uptake? - ✔✔Iodine. Thyroid uptake,TSH-mediated
✔✔I-131 Normal distribution? - ✔✔Stomach, GI, bladder. Variable: salivary,
nasopharynx,
✔✔I-131 MIBG dose? Gamma energies? Half-life? Time to imaging? - ✔✔2 mCi. 364
keV. 8 days. 48 hrs.
✔✔I-131 MIBG mechanism of uptake? - ✔✔Guanethidine analog. Norepinephrine
reuptake.
✔✔I-131 MIBG normal distribution? - ✔✔Liver > spleen. Variable: salivary, lung, GI,
bladder, skeletal muscle, heart.
✔✔I-123 MIBG dose? Gamma energies? Half-life? Time to imaging? - ✔✔1-10 mCi.
159 keV. 13 hrs. 24 hrs.
✔✔I-123 MIBG normal distribution? - ✔✔Liver > spleen. Variable: salivary, lung, GI,
bladder, skeletal muscle, heart.
✔✔In-111 octreoscan dose? Gamma energies? Half-life? Time to imaging? - ✔✔6 mCi.
172, 247 keV. 67 hrs. 4, 24 hrs.
✔✔Octreoscan mechanism of uptake? - ✔✔Somatostatin analog. Neuroendocrine
tumors.
✔✔In-111 octreoscan normal distribution? - ✔✔Intense renal cortex. Spleen, liver,
pituitary, salivary, GI, bladder. Variable: breast, thyroid.
✔✔FDG-PET dose? Gamma energies? Half-life? Time to imaging? - ✔✔10-15 mCi. 511
keV. 2 hrs. 1 hr.
✔✔FDG-PET mechanism of uptake? - ✔✔Glucose analog. Active transport into cell.
Phosphorylated and trapped.
✔✔FDG-Pet normal distribution - ✔✔Intense urinary activity and cerebral cortex. GU,
liver, spleen, marrow. Variable: thyroid, cardiac, GI, muscle.
✔✔In-111 WBC dose? Gamma energies? Half-life? Time to imaging? - ✔✔0.5 mCi.
172, 247 keV. 67 hrs. 24 hrs.
✔✔In-111 WBC mechanism of uptake? - ✔✔WBC localized at infection.
