GCU NUR 635 Midterm Exam – Complete Study Guide With Practice Questions & Detailed Answers
Pharmacokinetics includes - (answer)absorption, distribution, metabolism, elimination
absorption of drugs factors - (answer)PH changes, gastric emptying, gastric enzymes, bile acids, GI flora,
food and nutrient interactions, lipid solubility
Where is cyp450 system found - (answer)endoplasmic reticulum of hepatocytes
CYP3A4/5 - (answer)most abundant CYP450 isoform which metabolizes the most prescribed
" "drugs. Especially important for bioavailability due to its abundance in
" "cells lining the GI tract. Can be induced by a wide variety of drugs "
"and is potently inhibited by ketoconazole and erythromycin.
CYP2D6 - (answer)metabolizes 25% of prescribed drugs
*3*4*5 majority of bad metabolizers
Antidepressants
Antipsychotics
Antiarrythmics
*carvedilol, *metoprolol
*codeine → morphine
*tamoxifen to active
CYP2c8/9 - (answer)warfarin
CYP1A2 - (answer)AcetAminophen
CRAP GPS induces my rage - (answer)carbamazepine, rifampin,
alcohol, phenytoin, griseofulun, phenobarbitone, sulfonylureas
, GCU NUR 635 Midterm Exam – Complete Study Guide With Practice Questions & Detailed Answers
rectal admin has what absorption - (answer)variable and erratic
steady state (SS) is usually reached within how many half-lives of a drug - (answer)4-5
zero-order(nonlinear) pharmacokinetics means a drug is metabolized - (answer)at a constant rate per
unit time
Michaelis-menten pharmacokinetics - (answer)the rate of drug elimination is directly proportion to the
concentration of free drug (phenytoin)
theraputic index - (answer)TD50 = median toxic dose
ED50 = median effective dose
window = between those doses
safe drugs have a wider or high window/index
Agonist - (answer)drugs that alter the physiology of a cell by binding to plasma membrane or
intracellular receptors
Antagonists (drugs) - (answer)These drugs block the actions caused by agonists
off-label use - (answer)a drug can be used for an unapproved indication and is legitimate if there is
clinical data supporting its use for that indication
"safe" drug means - (answer)the FDA has determined the drugs benefits are greater than the possible
risks involved with its use
elimination of drugs most often involves what function - (answer)renal
Beta Blockers - (answer)-olol
Pharmacokinetics includes - (answer)absorption, distribution, metabolism, elimination
absorption of drugs factors - (answer)PH changes, gastric emptying, gastric enzymes, bile acids, GI flora,
food and nutrient interactions, lipid solubility
Where is cyp450 system found - (answer)endoplasmic reticulum of hepatocytes
CYP3A4/5 - (answer)most abundant CYP450 isoform which metabolizes the most prescribed
" "drugs. Especially important for bioavailability due to its abundance in
" "cells lining the GI tract. Can be induced by a wide variety of drugs "
"and is potently inhibited by ketoconazole and erythromycin.
CYP2D6 - (answer)metabolizes 25% of prescribed drugs
*3*4*5 majority of bad metabolizers
Antidepressants
Antipsychotics
Antiarrythmics
*carvedilol, *metoprolol
*codeine → morphine
*tamoxifen to active
CYP2c8/9 - (answer)warfarin
CYP1A2 - (answer)AcetAminophen
CRAP GPS induces my rage - (answer)carbamazepine, rifampin,
alcohol, phenytoin, griseofulun, phenobarbitone, sulfonylureas
, GCU NUR 635 Midterm Exam – Complete Study Guide With Practice Questions & Detailed Answers
rectal admin has what absorption - (answer)variable and erratic
steady state (SS) is usually reached within how many half-lives of a drug - (answer)4-5
zero-order(nonlinear) pharmacokinetics means a drug is metabolized - (answer)at a constant rate per
unit time
Michaelis-menten pharmacokinetics - (answer)the rate of drug elimination is directly proportion to the
concentration of free drug (phenytoin)
theraputic index - (answer)TD50 = median toxic dose
ED50 = median effective dose
window = between those doses
safe drugs have a wider or high window/index
Agonist - (answer)drugs that alter the physiology of a cell by binding to plasma membrane or
intracellular receptors
Antagonists (drugs) - (answer)These drugs block the actions caused by agonists
off-label use - (answer)a drug can be used for an unapproved indication and is legitimate if there is
clinical data supporting its use for that indication
"safe" drug means - (answer)the FDA has determined the drugs benefits are greater than the possible
risks involved with its use
elimination of drugs most often involves what function - (answer)renal
Beta Blockers - (answer)-olol
