Test Bank for Lehne's Pharmacotherapeutics
for Advanced Practice Nurses and Physician
Assistants, 3rd Edition
By Laura D. Rosenthal and Jacqueline Rosenjack Burchum
,Table of Contents
UNIT I: Introduction .................................................................................................................................. 6
Chapter 1: Prescriptive Authority. ........................................................................................................ 6
Chapter 2: Rational Drug Selection and Prescription Writing ............................................................ 20
Chapter 3: Promoting Positive Outcomes of Drug Therapy ............................................................... 34
UNIT II: Basic Principles of Pharmacology............................................................................................... 48
Chapter 4: Pharmacokinetics, Pharmacodynamics, and Drug Interactions........................................ 48
Chapter 5: Adverse Drug Reactions and Medication Errors ............................................................... 62
Chapter 6: Individual Variation in Drug Responses ............................................................................ 76
Chapter 7: Genetic and Genomic Considerations in Pharmacotherapeutics ..................................... 91
UNIT III: Drug Therapy Across the Life Span ......................................................................................... 105
Chapter 8: Drug Therapy During Pregnancy and Breastfeeding ....................................................... 105
Chapter 9: Drug Therapy in Pediatric Patients.................................................................................. 119
Chapter 10: Drug Therapy in Geriatric Patients ................................................................................ 133
UNIT IV Peripheral Nervous System Drugs ........................................................................................... 148
Chapter 11: Basic Principles of Neuropharmacology........................................................................ 148
Chapter 12: Physiology of the Peripheral Nervous System. ............................................................. 162
Chapter 13: Muscarinic Agonists and Cholinesterase Inhibitors. ..................................................... 176
Chapter 14: Muscarinic Antagonists ................................................................................................. 190
Chapter 15: Adrenergic Agonists, in detailed ................................................................................... 205
Chapter 16: Adrenergic Antagonists, in detailed .............................................................................. 220
Chapter 17: Indirect-Acting Antiadrenergic Agents .......................................................................... 234
UNIT V: Central Nervous System Drugs ................................................................................................ 249
Chapter 18: Introduction to Central Nervous System Pharmacology .............................................. 249
Chapter 19: Drugs for Parkinson Disease.......................................................................................... 264
Chapter 20: Drugs for Alzheimer Disease ......................................................................................... 278
Chapter 21: Drugs for Seizure Disorders, in detailed........................................................................ 292
Chapter 22: Drugs for Muscle Spasm and Spasticity ........................................................................ 306
UNIT VI: Drugs for Pain ......................................................................................................................... 320
Chapter 23: Local Anesthetics........................................................................................................... 320
Chapter 24: Opioid Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting Analgesics.... 335
Chapter 25: Drugs for Headache....................................................................................................... 350
UNIT VII: Psychotherapeutic Drugs ....................................................................................................... 364
, Chapter 26: Antipsychotic Agents and Their Use in Schizophrenia .................................................. 364
Chapter 27: Antidepressants ............................................................................................................ 379
Chapter 28: Drugs for Bipolar Disorder ............................................................................................ 393
Chapter 29: Sedative-Hypnotic Drugs ............................................................................................... 407
Chapter 30: Management of Anxiety Disorders ............................................................................... 421
Chapter 31: Central Nervous System Stimulants and Attention-Deficit/Hyperactivity Disorder
(ADHD) .............................................................................................................................................. 435
UNIT VIII: Substance Use Disorders ...................................................................................................... 449
Chapter 32: Substance Use Disorders I: Basic Considerations.......................................................... 449
Chapter 33: Substance Use Disorders II – Alcohol ............................................................................ 463
Chapter 34: Substance Use Disorders III – Nicotine and Smoking .................................................... 477
Chapter 35: Substance Use Disorders IV – Major Drugs of Misuse Other Than Alcohol and Nicotine
.......................................................................................................................................................... 491
UNIT IX: Drugs That Affect the Heart, Blood Vessels, Blood, and Blood Volume ................................. 506
Chapter 36: Review of Hemodynamics ............................................................................................. 506
Chapter 37: Diuretics ........................................................................................................................ 521
Chapter 38: Drugs Acting on the Renin-Angiotensin-Aldosterone System (RAAS) .......................... 536
Chapter 39: Calcium Channel Blockers (CCBs) .................................................................................. 550
Chapter 40: Vasodilators................................................................................................................... 564
Chapter 41: Drugs for Hypertension ................................................................................................. 578
Chapter 42. Drugs for Heart Failure .................................................................................................. 593
Chapter 43. Antidysrhythmic Drugs .................................................................................................. 608
Chapter 44. Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize
Cholesterol and Triglyceride Levels .................................................................................................. 623
Chapter 45. Drugs for Angina Pectoris .............................................................................................. 636
Chapter 46. Anticoagulant and Antiplatelet Drugs ........................................................................... 649
Chapter 47. Drugs for Deficiency Anemias ....................................................................................... 662
UNIT X: Drugs for Endocrine Disorders ................................................................................................. 675
Chapter 48. Drugs for Diabetes......................................................................................................... 675
Chapter 49. Drugs for Thyroid Disorders .......................................................................................... 688
UNIT XI: Reproductive Health ............................................................................................................... 701
Chapter 50. Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications .. 701
Chapter 51. Birth Control .................................................................................................................. 714
Chapter 52: Androgens ..................................................................................................................... 728
, Chapter 53: Drugs for Benign Prostatic Hyperplasia ........................................................................ 744
Chapter 54: Drugs for Sexual Dysfunction — (1–25) ........................................................................ 759
Chapter 55. Transgender Health ....................................................................................................... 773
UNIT XII: Antiinflammatory, Antiallergic, and Immunologic Drugs ...................................................... 787
Chapter 56. Review of the Immune System ..................................................................................... 787
Chapter 57. Childhood Immunization ............................................................................................... 801
Chapter 58. Antihistamines............................................................................................................... 815
Chapter 59. Cyclooxygenase Inhibitors, NSAIDs, and Acetaminophen ............................................ 828
Chapter 60. Glucocorticoids in Nonendocrine Disorders ................................................................. 841
UNIT XII: Antiinflammatory, Antiallergic, and Immunologic Drugs ...................................................... 855
Chapter 61. Drug Therapy for Rheumatoid Arthritis ........................................................................ 855
Chapter 62. Drug Therapy for Gout .................................................................................................. 862
Chapter 63. Drugs Affecting Calcium Levels and Bone Mineralization ............................................. 875
Chapter 64. Drugs for Asthma and COPD ......................................................................................... 888
Chapter 65. Drugs for Allergic Rhinitis, Cough, and Colds ................................................................ 901
Chapter 65. Drugs for Allergic Rhinitis, Cough, and Colds ................................................................ 908
UNIT XV: Gastrointestinal Drugs ........................................................................................................... 915
Chapter 66. Drugs for Peptic Ulcer Disease ...................................................................................... 915
Chapter 67. Laxatives ........................................................................................................................ 929
Chapter 68. Other Gastrointestinal Drugs ........................................................................................ 942
UNIT XVI: Nutrition and Complementary Therapies............................................................................. 955
Chapter 69. Vitamins......................................................................................................................... 955
Chapter 70. Drugs for Obesity .......................................................................................................... 968
Chapter 71. Complementary and Alternative Therapy..................................................................... 981
UNIT XVII: Therapy for Infectious and Parasitic Diseases ..................................................................... 994
Chapter 72. Basic Principles of Antimicrobial Therapy ..................................................................... 994
Chapter 73. Drugs That Weaken the Bacterial Cell Wall I: Penicillins............................................. 1007
Chapter 74. Drugs That Weaken the Bacterial Cell Wall II: Other Drugs ........................................ 1020
Chapter 75. Bacteriostatic Inhibitors of Protein Synthesis ............................................................. 1033
Chapter 76. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis ................................... 1046
Chapter 77. Sulfonamide Antibiotics and Trimethoprim ................................................................ 1059
Chapter 78. Drug Therapy for Urinary Tract Infections .................................................................. 1072
Chapter 79. Drug Therapy for Tuberculosis .................................................................................... 1085
for Advanced Practice Nurses and Physician
Assistants, 3rd Edition
By Laura D. Rosenthal and Jacqueline Rosenjack Burchum
,Table of Contents
UNIT I: Introduction .................................................................................................................................. 6
Chapter 1: Prescriptive Authority. ........................................................................................................ 6
Chapter 2: Rational Drug Selection and Prescription Writing ............................................................ 20
Chapter 3: Promoting Positive Outcomes of Drug Therapy ............................................................... 34
UNIT II: Basic Principles of Pharmacology............................................................................................... 48
Chapter 4: Pharmacokinetics, Pharmacodynamics, and Drug Interactions........................................ 48
Chapter 5: Adverse Drug Reactions and Medication Errors ............................................................... 62
Chapter 6: Individual Variation in Drug Responses ............................................................................ 76
Chapter 7: Genetic and Genomic Considerations in Pharmacotherapeutics ..................................... 91
UNIT III: Drug Therapy Across the Life Span ......................................................................................... 105
Chapter 8: Drug Therapy During Pregnancy and Breastfeeding ....................................................... 105
Chapter 9: Drug Therapy in Pediatric Patients.................................................................................. 119
Chapter 10: Drug Therapy in Geriatric Patients ................................................................................ 133
UNIT IV Peripheral Nervous System Drugs ........................................................................................... 148
Chapter 11: Basic Principles of Neuropharmacology........................................................................ 148
Chapter 12: Physiology of the Peripheral Nervous System. ............................................................. 162
Chapter 13: Muscarinic Agonists and Cholinesterase Inhibitors. ..................................................... 176
Chapter 14: Muscarinic Antagonists ................................................................................................. 190
Chapter 15: Adrenergic Agonists, in detailed ................................................................................... 205
Chapter 16: Adrenergic Antagonists, in detailed .............................................................................. 220
Chapter 17: Indirect-Acting Antiadrenergic Agents .......................................................................... 234
UNIT V: Central Nervous System Drugs ................................................................................................ 249
Chapter 18: Introduction to Central Nervous System Pharmacology .............................................. 249
Chapter 19: Drugs for Parkinson Disease.......................................................................................... 264
Chapter 20: Drugs for Alzheimer Disease ......................................................................................... 278
Chapter 21: Drugs for Seizure Disorders, in detailed........................................................................ 292
Chapter 22: Drugs for Muscle Spasm and Spasticity ........................................................................ 306
UNIT VI: Drugs for Pain ......................................................................................................................... 320
Chapter 23: Local Anesthetics........................................................................................................... 320
Chapter 24: Opioid Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting Analgesics.... 335
Chapter 25: Drugs for Headache....................................................................................................... 350
UNIT VII: Psychotherapeutic Drugs ....................................................................................................... 364
, Chapter 26: Antipsychotic Agents and Their Use in Schizophrenia .................................................. 364
Chapter 27: Antidepressants ............................................................................................................ 379
Chapter 28: Drugs for Bipolar Disorder ............................................................................................ 393
Chapter 29: Sedative-Hypnotic Drugs ............................................................................................... 407
Chapter 30: Management of Anxiety Disorders ............................................................................... 421
Chapter 31: Central Nervous System Stimulants and Attention-Deficit/Hyperactivity Disorder
(ADHD) .............................................................................................................................................. 435
UNIT VIII: Substance Use Disorders ...................................................................................................... 449
Chapter 32: Substance Use Disorders I: Basic Considerations.......................................................... 449
Chapter 33: Substance Use Disorders II – Alcohol ............................................................................ 463
Chapter 34: Substance Use Disorders III – Nicotine and Smoking .................................................... 477
Chapter 35: Substance Use Disorders IV – Major Drugs of Misuse Other Than Alcohol and Nicotine
.......................................................................................................................................................... 491
UNIT IX: Drugs That Affect the Heart, Blood Vessels, Blood, and Blood Volume ................................. 506
Chapter 36: Review of Hemodynamics ............................................................................................. 506
Chapter 37: Diuretics ........................................................................................................................ 521
Chapter 38: Drugs Acting on the Renin-Angiotensin-Aldosterone System (RAAS) .......................... 536
Chapter 39: Calcium Channel Blockers (CCBs) .................................................................................. 550
Chapter 40: Vasodilators................................................................................................................... 564
Chapter 41: Drugs for Hypertension ................................................................................................. 578
Chapter 42. Drugs for Heart Failure .................................................................................................. 593
Chapter 43. Antidysrhythmic Drugs .................................................................................................. 608
Chapter 44. Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize
Cholesterol and Triglyceride Levels .................................................................................................. 623
Chapter 45. Drugs for Angina Pectoris .............................................................................................. 636
Chapter 46. Anticoagulant and Antiplatelet Drugs ........................................................................... 649
Chapter 47. Drugs for Deficiency Anemias ....................................................................................... 662
UNIT X: Drugs for Endocrine Disorders ................................................................................................. 675
Chapter 48. Drugs for Diabetes......................................................................................................... 675
Chapter 49. Drugs for Thyroid Disorders .......................................................................................... 688
UNIT XI: Reproductive Health ............................................................................................................... 701
Chapter 50. Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications .. 701
Chapter 51. Birth Control .................................................................................................................. 714
Chapter 52: Androgens ..................................................................................................................... 728
, Chapter 53: Drugs for Benign Prostatic Hyperplasia ........................................................................ 744
Chapter 54: Drugs for Sexual Dysfunction — (1–25) ........................................................................ 759
Chapter 55. Transgender Health ....................................................................................................... 773
UNIT XII: Antiinflammatory, Antiallergic, and Immunologic Drugs ...................................................... 787
Chapter 56. Review of the Immune System ..................................................................................... 787
Chapter 57. Childhood Immunization ............................................................................................... 801
Chapter 58. Antihistamines............................................................................................................... 815
Chapter 59. Cyclooxygenase Inhibitors, NSAIDs, and Acetaminophen ............................................ 828
Chapter 60. Glucocorticoids in Nonendocrine Disorders ................................................................. 841
UNIT XII: Antiinflammatory, Antiallergic, and Immunologic Drugs ...................................................... 855
Chapter 61. Drug Therapy for Rheumatoid Arthritis ........................................................................ 855
Chapter 62. Drug Therapy for Gout .................................................................................................. 862
Chapter 63. Drugs Affecting Calcium Levels and Bone Mineralization ............................................. 875
Chapter 64. Drugs for Asthma and COPD ......................................................................................... 888
Chapter 65. Drugs for Allergic Rhinitis, Cough, and Colds ................................................................ 901
Chapter 65. Drugs for Allergic Rhinitis, Cough, and Colds ................................................................ 908
UNIT XV: Gastrointestinal Drugs ........................................................................................................... 915
Chapter 66. Drugs for Peptic Ulcer Disease ...................................................................................... 915
Chapter 67. Laxatives ........................................................................................................................ 929
Chapter 68. Other Gastrointestinal Drugs ........................................................................................ 942
UNIT XVI: Nutrition and Complementary Therapies............................................................................. 955
Chapter 69. Vitamins......................................................................................................................... 955
Chapter 70. Drugs for Obesity .......................................................................................................... 968
Chapter 71. Complementary and Alternative Therapy..................................................................... 981
UNIT XVII: Therapy for Infectious and Parasitic Diseases ..................................................................... 994
Chapter 72. Basic Principles of Antimicrobial Therapy ..................................................................... 994
Chapter 73. Drugs That Weaken the Bacterial Cell Wall I: Penicillins............................................. 1007
Chapter 74. Drugs That Weaken the Bacterial Cell Wall II: Other Drugs ........................................ 1020
Chapter 75. Bacteriostatic Inhibitors of Protein Synthesis ............................................................. 1033
Chapter 76. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis ................................... 1046
Chapter 77. Sulfonamide Antibiotics and Trimethoprim ................................................................ 1059
Chapter 78. Drug Therapy for Urinary Tract Infections .................................................................. 1072
Chapter 79. Drug Therapy for Tuberculosis .................................................................................... 1085
