PHARMACOLOOGY, TOXICOLOGY, #z
PHARMACOKINETICS #z
PHARMACOLOGY, #z TOXICOLOGY, #z PHARMACOKINETICS
1. Two #zdose-response #zcurve #zresponse #zplotted #zon #zthe #zsame #zgraph #zshowed #zsigmoid #zcurves #zhaving
#zthe #zsame #zslope #zand #zheight. #zT #zcurve #zis #zlocated #zto #zthe #zright #zof #zthe #zA #zcurve. #zWhich #zof #zthe
#zfollowing #zstatements #zis/are #zcorrect #zregarding #zcurves #zA #zan:
I. A #zis #zmore #zeffective #zthan #zB
II. A #zis #zmore #zpotent #zthan #zB
III. A #zand #zB #zhave #zthe #zsame #zceiling #zdose
IV. B #zis #zthe #zgraph #zproduced #zwhen #zA #zis #zgiven #zwith #zits #zcompetitive #zantagonist
V. B #zis #zthe #zgraph #zproduced #zwhen #zA #zis #zgiven #zwith #zits #znon-competitive #zantagonist
a. Only #zI #zand #zIII #zare #zcorrect
b. Only #zII, #zIII #zand #zIV #zare #zcorrect
c. Only #zII #zand #zIV #zare #zcorrect
d. Only #zIII #zand #zV #zare #zcorrect
e. Only #zV #zis #zcorrect
2. Two #zdose-response #zcurve #zplotted #zon #zthe #zsame #zgraph #zshowed #zsigmoid #zcurves #zA #zand #zB, #zwhere #zA
#zis #zat #zthe #zleft #zof #zthe #zgraph #z with #zthe #zheight #zgreater #zthan #zB. #zWhich #zof #zthe #zfollowing #zstatements
#zis/are #zcorrect #zregarding #zcurves #zA #zand #zB?
I. A #zand #zB #zhas #zequal #zefficacy
II. A #zand #zB #zhave #zequal #zpotency
III. B #zis #za #zpartial #zagonist #zof #zA
IV. B #zis #zthe #zgraph #zproduced #zwhen #zA #zis #zgiven #zwith #zits #zcompetitive #zantagonist
V. B #zis #zthe #zgraph #zproduced #zwhen #zA #zis #zgiven #zwith #zits #znon-competitive #zantagonist
, a. Only #zI #zand #zIII #zare #zcorrect
b. Only #zII, #zIII #zand #zIV #zare #zcorrect
c. Only #zII #zand #zIV #zare #zcorrect
d. Only #zIII #zand #zV #zare #zcorrect
e. Only #zV #zis #zcorrect
3. The #zcumulative #znumber #zof #zsubjects #zwho #zdisplay #za #zcertain #zrersponse #zor #zeffect #zto #za #zdrug #zis
#zplotted #zon #za #zgraph #zas #zshown #zbelow. #zThe #zgraph #zon #zthe #zleft #zrepresents #zbeneficial #zeffect #z while
#zthe #zgraph #zon #zthe #zright #zrepresents #ztoxic #zeffect, #z what #zis #zthe #ztherapeutic #zindex #zof #zthe #zdrug?
a.0.5 b. #z1.5 c. #z2.5 d.4.0 e. #z5.0
4. An #zadministration #zof #zone #zdrug #zleads #zto #za #zshift #zin #zthe #zlog #zdose-response #zcurve #zof #zanother
#zdrug #zto #zthe #zleft #za #zrange #zin #zthe #zmaximal #zefficacy, #zthis #zis #zcalled
a. Agonism
b. Partial #zagonism
c. Non-competitive # z antagonism
d. Competitive #zantagonism
e. Potentiation
5. The #zaction #zof #zthis #zdrug #zis #zdependent #zon #za #zcolligative #zproperty
a. Mannitol
b. Cocaine
c. Reserpine
d. Furosemide
e. Losartan
6. Whiich #zof #zthe #zfollowing #zdrug #zgroups #zhave #zmechanisms #zof #zaaction #zthat #zinvolve #zbinding #zto
#zenzymes #zas #ztarget #zprotiens
a. Benzodiazepines
b. Barbiturates
c. Calcium #zchannel #zblockers
d. Non-steroidal # z anti-inflammatory # z agents
e. Phenothiazine # z antipsychotics
7. Voltage-gated #zion #zchannels #zserve #zas #zsite #zof #zactions #zfor #zdrugs #zsuch #zas
I. Diltiazem #zand #zNifedipine
II. Lidocaine #zand #zProcaine
III. Captopril #zand #zLosartan
a. I #zonly
b. I #zand #zII
c. III #zonly
, d. I and III
e. I, II, and III
8. Drugs with mechanism of action that involves Tubulin-binding leading to loss of function of the structural
protien include
a. Cyclosporine
b. Neostigmine
c. Colchicine
d. Glibenclamide
e. Metformin
9. What type of protien is primarily targeted by Digitalis glycosides when they exert their effect on the heart?
a. Receptors
b. Ion channels
c. Enzymes
d. Transporters
e. Structural protiens
10. Which of the following features cahracterize nicotinic, GABA-A, and Glutamate receptors?
a. Thay control the movements of ions and out of the cell
b. Their action is mediated bysecondary messengers
c. They all have excitatory effect on the cell membrane
d. They are located on the cytoplasm
11. Which of the following drugs bind to receptors located at the cell membrane?
a. Thyroid hormone
b. Prednisone
c. Estrogen
d. Insulin
e. Vitamin D
12. Cyclic Adenosine Monophophate (cAMP) is generated as a secondary messenger by the action of the
enzyme Adenylyl Cyclase. The substrate for the synthesis of cAMP is
a. AMD
b. ADP
c. ATP
d. GTP
e. Adenosine
13. Stimulation of Beta-adrenoceptor, a G-protien-linked receptor involves a generation of a secondary
messenger known as
a. IP3
b. cGTP
c. DAG
d. cAMP
e. Calcium ions
14. What is the mechanism of action of Sildenafil, a drug popularly known as viagra?
a. Inhibits phosphodiesterase (PDE) leading to increase cAMP
b. Inhibits PDE leading to increase cGMP
c. Stimulates adenylyl cyclase leading to increase cAMP
d. Stimulates guanylyl cyclase leading to increase cGMP
e. Inhibits phosphodiesterase leading to increase cGMP
15. Drugs that activate the phospholipase C-inositol phosphate system such as alpha-adrenergic agonists like
phenylephrine primarily cause an increase in the intracellular levels of which ion?
a. Calcium
, b. Magnesium
c. Sodium
d. Potassium
e. Chloride
16. Which #zof #zthe #zfollowing #zstetements #zcharacterizes #zcompetitive #zantagonism?
a. There #zis #za #zshift #zof #zthe # z agonist #zlog #zconcentration-effect #zcurve #zto #zthe #zright #zand
#zdownwards
b. There #zis #za #zshift #zof #zthe #zagonist #zlog #zconcentration-effect #zcurve #zto #zthe #zright #zwithout #za
#zchange #zon #zthe #zslope #zor #zamplitude
c. There #zis #zan #zexponential #zrelationship #zbetween #zdose #zratio #zand #zantagonist #zconcentration
d. There #zis #zno #zcompetition #zfor #zthe #zbinding #zsites
e. There #zis #za #zshift #zof #zthe #zagonist #zlog-concentration #zeffect #zcurve #zto #zthe #zleft #zwithout #za
#zchange #zin #zslope #zand #zamplitude
17. The #zminimum #zdose #zthat #zproduces #zthe #zmaximum #zachievable #zresponse #zis #zknown #zas
a. Potency
b. ED50
c. LD50
d. Ceiling #zdose
e. Minimum #zeffective #zdose
18. The #zmedium #zdose, #zor #zthe #zdose #zof #zthe #zdrug #zthat #zproduces #zhalf #zof #zthe #zmaximum #zachievable
#zresponse #zis #zcalled
a. Potency d. #zCeiling #zdose
b. LD50 e. #zBinding #zconstant
c. Therapeutic #zindex
19. What #zis #zdescribed #zby #zthe #zequation #zgiven #zas
#zfollows: #zResponse=f #z(EN #ztotal # z . # z Xa
# z / #z(Xa # z + #zKa)
a. Relationship #zbetween #zoccupancy #zof #zreceptor #zand #zthe #zdose #zof #zthe #zdrug
b. Relationship #zbetween #zoccupancy #zof #zreceptor #zand #zresponse #zto #zthe #zdrug
c. Relationship #zbetween #zthe #zdose #zof #zthe #zdrug #zand #zthe #zresponse #zto #zthe #zdrug
d. Relationship #zbetween #zthe #znumber #zof #zreceptors #zand #zthe #zdose #zof #zthe #zdrug
e. Relationship #zbetween #zthe #zresponse #zto #zthe #zdrug #zand #zthe #ztransducer #zfunction #zof #zthe #ztissues
20. Competitive #zantagonist #zof #zthe #zreceptors #zof #zDopamine #zand #zBenzodiazepine #zare #zexpected #zto
#zproduced #zwhich #zeffect?
a. Reversal #zof #zthe #zintrinsic #zactivity #zof #zthe #zreceptors
b. Maintain #zthe #zconsitutive #zactivity #zof #zthe #zreceptors
c. Stimulate #zthe #zconstitutive #zactivity #zof #zthe #zreceptors
d. Stimulate #zthe #zconstitutive #zactivity #zof #zthe #zrecptorsin #zthe #zabsence #zof #zany #zligand
e. Produce #za #znegative #zefficacy
21. The #zPT-INR #zof #za #zpatient #zwith #zWarfarin #zhas #zbeen #zmaintained #zat #z2.5 #zfor #zthe #zlast #z3 #zmonths. #z1
#zweek #zearlier, #zthe #zpatient #zwas #zgiven #zPhenobarbital. #zWhat #zcan #zbe #zexpected #zwith #zthe #zPT-INR #zof
#zthe #zpatient?
a. Increased #zPT-INR
b. Decreased #zPT-INR
c. Maintained #zPT-INR
22. Phenobarbital #zwhen #zgiven #zto #za #zpatient #zon #zchronic #zwarfarin #zis #zclassified #zas
a. Pharmacodynamic #z antagonist
b. Pharmacokinetic # z antagonist
c. Physiologic #zantagonist
d. Synergistic #zagonist
e. Additive #zagonist
23. Digibind #zwhich #zeffetively #zterminates #zthe #zaction #zof #zDigitalis #zglycosides #zis #zclassified #zas
#zwhat #ztype #zof #zantagonist?
PHARMACOKINETICS #z
PHARMACOLOGY, #z TOXICOLOGY, #z PHARMACOKINETICS
1. Two #zdose-response #zcurve #zresponse #zplotted #zon #zthe #zsame #zgraph #zshowed #zsigmoid #zcurves #zhaving
#zthe #zsame #zslope #zand #zheight. #zT #zcurve #zis #zlocated #zto #zthe #zright #zof #zthe #zA #zcurve. #zWhich #zof #zthe
#zfollowing #zstatements #zis/are #zcorrect #zregarding #zcurves #zA #zan:
I. A #zis #zmore #zeffective #zthan #zB
II. A #zis #zmore #zpotent #zthan #zB
III. A #zand #zB #zhave #zthe #zsame #zceiling #zdose
IV. B #zis #zthe #zgraph #zproduced #zwhen #zA #zis #zgiven #zwith #zits #zcompetitive #zantagonist
V. B #zis #zthe #zgraph #zproduced #zwhen #zA #zis #zgiven #zwith #zits #znon-competitive #zantagonist
a. Only #zI #zand #zIII #zare #zcorrect
b. Only #zII, #zIII #zand #zIV #zare #zcorrect
c. Only #zII #zand #zIV #zare #zcorrect
d. Only #zIII #zand #zV #zare #zcorrect
e. Only #zV #zis #zcorrect
2. Two #zdose-response #zcurve #zplotted #zon #zthe #zsame #zgraph #zshowed #zsigmoid #zcurves #zA #zand #zB, #zwhere #zA
#zis #zat #zthe #zleft #zof #zthe #zgraph #z with #zthe #zheight #zgreater #zthan #zB. #zWhich #zof #zthe #zfollowing #zstatements
#zis/are #zcorrect #zregarding #zcurves #zA #zand #zB?
I. A #zand #zB #zhas #zequal #zefficacy
II. A #zand #zB #zhave #zequal #zpotency
III. B #zis #za #zpartial #zagonist #zof #zA
IV. B #zis #zthe #zgraph #zproduced #zwhen #zA #zis #zgiven #zwith #zits #zcompetitive #zantagonist
V. B #zis #zthe #zgraph #zproduced #zwhen #zA #zis #zgiven #zwith #zits #znon-competitive #zantagonist
, a. Only #zI #zand #zIII #zare #zcorrect
b. Only #zII, #zIII #zand #zIV #zare #zcorrect
c. Only #zII #zand #zIV #zare #zcorrect
d. Only #zIII #zand #zV #zare #zcorrect
e. Only #zV #zis #zcorrect
3. The #zcumulative #znumber #zof #zsubjects #zwho #zdisplay #za #zcertain #zrersponse #zor #zeffect #zto #za #zdrug #zis
#zplotted #zon #za #zgraph #zas #zshown #zbelow. #zThe #zgraph #zon #zthe #zleft #zrepresents #zbeneficial #zeffect #z while
#zthe #zgraph #zon #zthe #zright #zrepresents #ztoxic #zeffect, #z what #zis #zthe #ztherapeutic #zindex #zof #zthe #zdrug?
a.0.5 b. #z1.5 c. #z2.5 d.4.0 e. #z5.0
4. An #zadministration #zof #zone #zdrug #zleads #zto #za #zshift #zin #zthe #zlog #zdose-response #zcurve #zof #zanother
#zdrug #zto #zthe #zleft #za #zrange #zin #zthe #zmaximal #zefficacy, #zthis #zis #zcalled
a. Agonism
b. Partial #zagonism
c. Non-competitive # z antagonism
d. Competitive #zantagonism
e. Potentiation
5. The #zaction #zof #zthis #zdrug #zis #zdependent #zon #za #zcolligative #zproperty
a. Mannitol
b. Cocaine
c. Reserpine
d. Furosemide
e. Losartan
6. Whiich #zof #zthe #zfollowing #zdrug #zgroups #zhave #zmechanisms #zof #zaaction #zthat #zinvolve #zbinding #zto
#zenzymes #zas #ztarget #zprotiens
a. Benzodiazepines
b. Barbiturates
c. Calcium #zchannel #zblockers
d. Non-steroidal # z anti-inflammatory # z agents
e. Phenothiazine # z antipsychotics
7. Voltage-gated #zion #zchannels #zserve #zas #zsite #zof #zactions #zfor #zdrugs #zsuch #zas
I. Diltiazem #zand #zNifedipine
II. Lidocaine #zand #zProcaine
III. Captopril #zand #zLosartan
a. I #zonly
b. I #zand #zII
c. III #zonly
, d. I and III
e. I, II, and III
8. Drugs with mechanism of action that involves Tubulin-binding leading to loss of function of the structural
protien include
a. Cyclosporine
b. Neostigmine
c. Colchicine
d. Glibenclamide
e. Metformin
9. What type of protien is primarily targeted by Digitalis glycosides when they exert their effect on the heart?
a. Receptors
b. Ion channels
c. Enzymes
d. Transporters
e. Structural protiens
10. Which of the following features cahracterize nicotinic, GABA-A, and Glutamate receptors?
a. Thay control the movements of ions and out of the cell
b. Their action is mediated bysecondary messengers
c. They all have excitatory effect on the cell membrane
d. They are located on the cytoplasm
11. Which of the following drugs bind to receptors located at the cell membrane?
a. Thyroid hormone
b. Prednisone
c. Estrogen
d. Insulin
e. Vitamin D
12. Cyclic Adenosine Monophophate (cAMP) is generated as a secondary messenger by the action of the
enzyme Adenylyl Cyclase. The substrate for the synthesis of cAMP is
a. AMD
b. ADP
c. ATP
d. GTP
e. Adenosine
13. Stimulation of Beta-adrenoceptor, a G-protien-linked receptor involves a generation of a secondary
messenger known as
a. IP3
b. cGTP
c. DAG
d. cAMP
e. Calcium ions
14. What is the mechanism of action of Sildenafil, a drug popularly known as viagra?
a. Inhibits phosphodiesterase (PDE) leading to increase cAMP
b. Inhibits PDE leading to increase cGMP
c. Stimulates adenylyl cyclase leading to increase cAMP
d. Stimulates guanylyl cyclase leading to increase cGMP
e. Inhibits phosphodiesterase leading to increase cGMP
15. Drugs that activate the phospholipase C-inositol phosphate system such as alpha-adrenergic agonists like
phenylephrine primarily cause an increase in the intracellular levels of which ion?
a. Calcium
, b. Magnesium
c. Sodium
d. Potassium
e. Chloride
16. Which #zof #zthe #zfollowing #zstetements #zcharacterizes #zcompetitive #zantagonism?
a. There #zis #za #zshift #zof #zthe # z agonist #zlog #zconcentration-effect #zcurve #zto #zthe #zright #zand
#zdownwards
b. There #zis #za #zshift #zof #zthe #zagonist #zlog #zconcentration-effect #zcurve #zto #zthe #zright #zwithout #za
#zchange #zon #zthe #zslope #zor #zamplitude
c. There #zis #zan #zexponential #zrelationship #zbetween #zdose #zratio #zand #zantagonist #zconcentration
d. There #zis #zno #zcompetition #zfor #zthe #zbinding #zsites
e. There #zis #za #zshift #zof #zthe #zagonist #zlog-concentration #zeffect #zcurve #zto #zthe #zleft #zwithout #za
#zchange #zin #zslope #zand #zamplitude
17. The #zminimum #zdose #zthat #zproduces #zthe #zmaximum #zachievable #zresponse #zis #zknown #zas
a. Potency
b. ED50
c. LD50
d. Ceiling #zdose
e. Minimum #zeffective #zdose
18. The #zmedium #zdose, #zor #zthe #zdose #zof #zthe #zdrug #zthat #zproduces #zhalf #zof #zthe #zmaximum #zachievable
#zresponse #zis #zcalled
a. Potency d. #zCeiling #zdose
b. LD50 e. #zBinding #zconstant
c. Therapeutic #zindex
19. What #zis #zdescribed #zby #zthe #zequation #zgiven #zas
#zfollows: #zResponse=f #z(EN #ztotal # z . # z Xa
# z / #z(Xa # z + #zKa)
a. Relationship #zbetween #zoccupancy #zof #zreceptor #zand #zthe #zdose #zof #zthe #zdrug
b. Relationship #zbetween #zoccupancy #zof #zreceptor #zand #zresponse #zto #zthe #zdrug
c. Relationship #zbetween #zthe #zdose #zof #zthe #zdrug #zand #zthe #zresponse #zto #zthe #zdrug
d. Relationship #zbetween #zthe #znumber #zof #zreceptors #zand #zthe #zdose #zof #zthe #zdrug
e. Relationship #zbetween #zthe #zresponse #zto #zthe #zdrug #zand #zthe #ztransducer #zfunction #zof #zthe #ztissues
20. Competitive #zantagonist #zof #zthe #zreceptors #zof #zDopamine #zand #zBenzodiazepine #zare #zexpected #zto
#zproduced #zwhich #zeffect?
a. Reversal #zof #zthe #zintrinsic #zactivity #zof #zthe #zreceptors
b. Maintain #zthe #zconsitutive #zactivity #zof #zthe #zreceptors
c. Stimulate #zthe #zconstitutive #zactivity #zof #zthe #zreceptors
d. Stimulate #zthe #zconstitutive #zactivity #zof #zthe #zrecptorsin #zthe #zabsence #zof #zany #zligand
e. Produce #za #znegative #zefficacy
21. The #zPT-INR #zof #za #zpatient #zwith #zWarfarin #zhas #zbeen #zmaintained #zat #z2.5 #zfor #zthe #zlast #z3 #zmonths. #z1
#zweek #zearlier, #zthe #zpatient #zwas #zgiven #zPhenobarbital. #zWhat #zcan #zbe #zexpected #zwith #zthe #zPT-INR #zof
#zthe #zpatient?
a. Increased #zPT-INR
b. Decreased #zPT-INR
c. Maintained #zPT-INR
22. Phenobarbital #zwhen #zgiven #zto #za #zpatient #zon #zchronic #zwarfarin #zis #zclassified #zas
a. Pharmacodynamic #z antagonist
b. Pharmacokinetic # z antagonist
c. Physiologic #zantagonist
d. Synergistic #zagonist
e. Additive #zagonist
23. Digibind #zwhich #zeffetively #zterminates #zthe #zaction #zof #zDigitalis #zglycosides #zis #zclassified #zas
#zwhat #ztype #zof #zantagonist?
