Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. Which principle best defines the practice of medicine as
described in Harrison’s?
A. Application of protocols without deviation
B. Integration of science, clinical judgment, and compassion
C. Reliance on technology over physical examination
D. Disease treatment rather than patient-centered care
Correct Answer: B
Rationale: Harrison’s emphasizes medicine as both a science
and an art, requiring evidence-based knowledge combined with
clinical reasoning, ethics, and empathy.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 1: The Practice of Medicine
,2. Which nursing action most directly supports health
promotion at the population level?
A. Administering acute medications
B. Encouraging adherence after diagnosis
C. Supporting lifestyle modification before disease onset
D. Monitoring for disease complications
Correct Answer: C
Rationale: Health promotion focuses on preventing disease
through behavioral, environmental, and social interventions
before illness develops.
Citation: Harrison’s, 22nd ed., Chapter 2: Promoting Good
Health
3. Vaccine hesitancy is most commonly driven by which
factor?
A. Lack of vaccine availability
B. Religious doctrine alone
C. Mistrust and misinformation
D. Vaccine cost
Correct Answer: C
Rationale: Harrison’s identifies misinformation, mistrust of
institutions, and perceived risk as primary contributors to
vaccine opposition.
Citation: Harrison’s, 22nd ed., Chapter 3: Vaccine Opposition
and Hesitancy
,4. A key nursing role in addressing vaccine hesitancy is:
A. Enforcing vaccination policies
B. Avoiding discussion of risks
C. Providing empathetic, evidence-based counseling
D. Delegating education to physicians only
Correct Answer: C
Rationale: Respectful dialogue that acknowledges concerns
while presenting scientific evidence improves vaccine
acceptance.
Citation: Harrison’s, 22nd ed., Chapter 3
5. Clinical decision-making is MOST improved by:
A. Ordering more diagnostic tests
B. Pattern recognition combined with analytic reasoning
C. Relying solely on guidelines
D. Avoiding uncertainty
Correct Answer: B
Rationale: Harrison’s highlights dual-process thinking—intuitive
and analytical—as central to sound clinical decisions.
Citation: Harrison’s, 22nd ed., Chapter 4: Decision-Making in
Clinical Medicine
6. Which factor increases the risk of diagnostic error?
, A. Interprofessional communication
B. Cognitive bias
C. Structured reflection
D. Clinical checklists
Correct Answer: B
Rationale: Cognitive biases such as anchoring and premature
closure are major contributors to diagnostic error.
Citation: Harrison’s, 22nd ed., Chapter 4
7. Precision medicine primarily aims to:
A. Replace clinical judgment
B. Apply population averages to all patients
C. Tailor care based on genetic and molecular data
D. Reduce the need for prevention
Correct Answer: C
Rationale: Precision medicine integrates genomics and
biomarkers to individualize prevention and treatment
strategies.
Citation: Harrison’s, 22nd ed., Chapter 5: Precision Medicine
and Clinical Care
8. A nursing implication of precision medicine includes:
A. Eliminating patient education
B. Increased focus on informed consent
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. Which principle best defines the practice of medicine as
described in Harrison’s?
A. Application of protocols without deviation
B. Integration of science, clinical judgment, and compassion
C. Reliance on technology over physical examination
D. Disease treatment rather than patient-centered care
Correct Answer: B
Rationale: Harrison’s emphasizes medicine as both a science
and an art, requiring evidence-based knowledge combined with
clinical reasoning, ethics, and empathy.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 1: The Practice of Medicine
,2. Which nursing action most directly supports health
promotion at the population level?
A. Administering acute medications
B. Encouraging adherence after diagnosis
C. Supporting lifestyle modification before disease onset
D. Monitoring for disease complications
Correct Answer: C
Rationale: Health promotion focuses on preventing disease
through behavioral, environmental, and social interventions
before illness develops.
Citation: Harrison’s, 22nd ed., Chapter 2: Promoting Good
Health
3. Vaccine hesitancy is most commonly driven by which
factor?
A. Lack of vaccine availability
B. Religious doctrine alone
C. Mistrust and misinformation
D. Vaccine cost
Correct Answer: C
Rationale: Harrison’s identifies misinformation, mistrust of
institutions, and perceived risk as primary contributors to
vaccine opposition.
Citation: Harrison’s, 22nd ed., Chapter 3: Vaccine Opposition
and Hesitancy
,4. A key nursing role in addressing vaccine hesitancy is:
A. Enforcing vaccination policies
B. Avoiding discussion of risks
C. Providing empathetic, evidence-based counseling
D. Delegating education to physicians only
Correct Answer: C
Rationale: Respectful dialogue that acknowledges concerns
while presenting scientific evidence improves vaccine
acceptance.
Citation: Harrison’s, 22nd ed., Chapter 3
5. Clinical decision-making is MOST improved by:
A. Ordering more diagnostic tests
B. Pattern recognition combined with analytic reasoning
C. Relying solely on guidelines
D. Avoiding uncertainty
Correct Answer: B
Rationale: Harrison’s highlights dual-process thinking—intuitive
and analytical—as central to sound clinical decisions.
Citation: Harrison’s, 22nd ed., Chapter 4: Decision-Making in
Clinical Medicine
6. Which factor increases the risk of diagnostic error?
, A. Interprofessional communication
B. Cognitive bias
C. Structured reflection
D. Clinical checklists
Correct Answer: B
Rationale: Cognitive biases such as anchoring and premature
closure are major contributors to diagnostic error.
Citation: Harrison’s, 22nd ed., Chapter 4
7. Precision medicine primarily aims to:
A. Replace clinical judgment
B. Apply population averages to all patients
C. Tailor care based on genetic and molecular data
D. Reduce the need for prevention
Correct Answer: C
Rationale: Precision medicine integrates genomics and
biomarkers to individualize prevention and treatment
strategies.
Citation: Harrison’s, 22nd ed., Chapter 5: Precision Medicine
and Clinical Care
8. A nursing implication of precision medicine includes:
A. Eliminating patient education
B. Increased focus on informed consent
