BCPS STUDY GUIDE 2026 EXAM QUESTIONS AND
ANSWERS GRADED A+
✔✔NNRTI that inhibits not induces - ✔✔delavridine
✔✔what SNP is a problem with carbamazepine - ✔✔HLA-B*1502
✔✔what SNP is a problem with abacavir - ✔✔HLA-B*5701
✔✔more potent isomer of warfarin; cyp it goes - ✔✔S-isomer; 2C9
✔✔less potent isomer of warfarin; Cyp it goes through - ✔✔R-isomer; 3A4
✔✔inhibitors of 2C9 (4 A, S, M, F) - ✔✔Amiodarone, SMX/TMP, metronidazole,
Fluconazole
✔✔what cyp is most important for clopidogrel activation - ✔✔2C19
✔✔Which PPIs inhibit Cyp 2C19 - ✔✔omeprazole, lansoprazole
✔✔diltiazem/verapamil's mechanis of drug interactions (2) - ✔✔3a4, Pgp
✔✔what to paroxetine/fluoxetine inhibit - ✔✔2d6
✔✔how is gemfibrozil and simvastatin interaction mediated - ✔✔UGT
✔✔what drug requires 2d6 to be activated - ✔✔tamoxifen
✔✔lamotrigine and divalproex mechanism of interaction - ✔✔UGT
✔✔digoxin is a major substate of what - ✔✔Pgp
✔✔Iron absorption is inhibited by - ✔✔antacids
✔✔Drugs that need acidic environment for absoprtion (6: I, K, P, A, D, E) -
✔✔Itraconazole capsules, ketoconazole, posaconazole, atazanavir, dasatinib, erlotinib
✔✔What drug should never be used w/ xanthine oxide inhibitors - ✔✔azathioprine
✔✔What mediates Type 1 hypersensitivity reactions - ✔✔IgE, mast cells and basophils
releasing histamine
, ✔✔What are 2 examples of Type 1 hypersnsitivity reactions - ✔✔anaphylaxis and acute
allergic rhinitis
✔✔What is the onset of Type 1 hypersensitivity reactions - ✔✔minutes
✔✔What mediates Type 2 hypersensitivity reactions - ✔✔IGG or IGM binding to surface
Ag and complement activation
✔✔What are 4 examples of Type 2 hypersnsitivity reactions - ✔✔drug allergies, blood
incompatibility, transplant rejections, autoimmune diseases
✔✔What is the onset of Type 2 hypersensitivity reactions - ✔✔hours
✔✔What mediates Type 3 hypersensitivity reactions - ✔✔IgG/AG complex deposit in
vessels
✔✔What are 3 examples of Type 3 hypersnsitivity reactions - ✔✔serum sickness, post
strep glomerulonephritis, subacute bacterial endocarditis
✔✔What is the onset of Type 3 hypersensitivity reactions - ✔✔5 to 10 days
✔✔what is standard treatment for type 2, 3, 4 hypersensitivity reactions - ✔✔avoidance,
steroids
✔✔What mediates Type 4 hypersensitivity reactions - ✔✔T-cells delayed reaction,
particularly NK cells (CD8)
✔✔What are 4 examples of Type 4 hypersnsitivity reactions - ✔✔contact dermatitis,
celiac disease, abacavir and CBZ drug reaction, TB testing
✔✔What is the onset of Type 4 hypersensitivity reactions - ✔✔2 to 3 days
✔✔what are the 3 steps of type 1 hypersensitivity reactions - ✔✔sensitization-
immediate-late-phase
✔✔When to do supplemental oxygen in type 1 hypersensitivity - ✔✔Pulse ox <90
✔✔Epinephrine for hypersensitivity IM dose - ✔✔0.2-0.5mg (use 1:1000)
✔✔Epinephrine for hypersensitivity IV dose - ✔✔0.1mg (use 1:10,000)
✔✔4 drugs to give for type 1 hypersensitivity - ✔✔epinephrine, diphenhydramine,
famotidine, steroids
ANSWERS GRADED A+
✔✔NNRTI that inhibits not induces - ✔✔delavridine
✔✔what SNP is a problem with carbamazepine - ✔✔HLA-B*1502
✔✔what SNP is a problem with abacavir - ✔✔HLA-B*5701
✔✔more potent isomer of warfarin; cyp it goes - ✔✔S-isomer; 2C9
✔✔less potent isomer of warfarin; Cyp it goes through - ✔✔R-isomer; 3A4
✔✔inhibitors of 2C9 (4 A, S, M, F) - ✔✔Amiodarone, SMX/TMP, metronidazole,
Fluconazole
✔✔what cyp is most important for clopidogrel activation - ✔✔2C19
✔✔Which PPIs inhibit Cyp 2C19 - ✔✔omeprazole, lansoprazole
✔✔diltiazem/verapamil's mechanis of drug interactions (2) - ✔✔3a4, Pgp
✔✔what to paroxetine/fluoxetine inhibit - ✔✔2d6
✔✔how is gemfibrozil and simvastatin interaction mediated - ✔✔UGT
✔✔what drug requires 2d6 to be activated - ✔✔tamoxifen
✔✔lamotrigine and divalproex mechanism of interaction - ✔✔UGT
✔✔digoxin is a major substate of what - ✔✔Pgp
✔✔Iron absorption is inhibited by - ✔✔antacids
✔✔Drugs that need acidic environment for absoprtion (6: I, K, P, A, D, E) -
✔✔Itraconazole capsules, ketoconazole, posaconazole, atazanavir, dasatinib, erlotinib
✔✔What drug should never be used w/ xanthine oxide inhibitors - ✔✔azathioprine
✔✔What mediates Type 1 hypersensitivity reactions - ✔✔IgE, mast cells and basophils
releasing histamine
, ✔✔What are 2 examples of Type 1 hypersnsitivity reactions - ✔✔anaphylaxis and acute
allergic rhinitis
✔✔What is the onset of Type 1 hypersensitivity reactions - ✔✔minutes
✔✔What mediates Type 2 hypersensitivity reactions - ✔✔IGG or IGM binding to surface
Ag and complement activation
✔✔What are 4 examples of Type 2 hypersnsitivity reactions - ✔✔drug allergies, blood
incompatibility, transplant rejections, autoimmune diseases
✔✔What is the onset of Type 2 hypersensitivity reactions - ✔✔hours
✔✔What mediates Type 3 hypersensitivity reactions - ✔✔IgG/AG complex deposit in
vessels
✔✔What are 3 examples of Type 3 hypersnsitivity reactions - ✔✔serum sickness, post
strep glomerulonephritis, subacute bacterial endocarditis
✔✔What is the onset of Type 3 hypersensitivity reactions - ✔✔5 to 10 days
✔✔what is standard treatment for type 2, 3, 4 hypersensitivity reactions - ✔✔avoidance,
steroids
✔✔What mediates Type 4 hypersensitivity reactions - ✔✔T-cells delayed reaction,
particularly NK cells (CD8)
✔✔What are 4 examples of Type 4 hypersnsitivity reactions - ✔✔contact dermatitis,
celiac disease, abacavir and CBZ drug reaction, TB testing
✔✔What is the onset of Type 4 hypersensitivity reactions - ✔✔2 to 3 days
✔✔what are the 3 steps of type 1 hypersensitivity reactions - ✔✔sensitization-
immediate-late-phase
✔✔When to do supplemental oxygen in type 1 hypersensitivity - ✔✔Pulse ox <90
✔✔Epinephrine for hypersensitivity IM dose - ✔✔0.2-0.5mg (use 1:1000)
✔✔Epinephrine for hypersensitivity IV dose - ✔✔0.1mg (use 1:10,000)
✔✔4 drugs to give for type 1 hypersensitivity - ✔✔epinephrine, diphenhydramine,
famotidine, steroids
