Medical-Surgical Nursing MCQ Study Guide & Practice Test Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. The Practice of Medicine
1. Which principle best defines evidence-based clinical practice
in modern medicine?
A. Reliance on expert opinion
B. Use of randomized trials only
C. Integration of best evidence with clinical expertise and
patient values
D. Adherence to standardized protocols
Correct Answer: C
Rationale: Evidence-based medicine integrates scientific
evidence, clinician expertise, and patient preferences.
Citation: Harrison’s 22nd ed., Ch. 1 – The Practice of Medicine


2. Promoting Good Health
2. Which intervention has the greatest population-level impact
on reducing cardiovascular disease risk?

,A. Genetic screening
B. Pharmacologic therapy
C. Lifestyle modification
D. Surgical intervention
Correct Answer: C
Rationale: Behavioral changes (diet, exercise, smoking
cessation) yield the greatest public health benefit.
Citation: Harrison’s 22nd ed., Ch. 2 – Promoting Good Health


3. Vaccine Opposition and Hesitancy
3. A major driver of vaccine hesitancy identified in Harrison’s is:
A. Vaccine supply shortages
B. Distrust of health institutions
C. Cost of vaccination
D. Lack of trained providers
Correct Answer: B
Rationale: Mistrust and misinformation are central contributors
to vaccine hesitancy.
Citation: Harrison’s 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy


4. Decision-Making in Clinical Medicine
4. Shared decision-making is most appropriate when:
A. Evidence strongly favors one option

, B. Multiple reasonable options exist
C. The patient lacks decisional capacity
D. Time-sensitive emergencies occur
Correct Answer: B
Rationale: Shared decision-making is essential when benefits
and risks are closely balanced.
Citation: Harrison’s 22nd ed., Ch. 4 – Decision-Making in Clinical
Medicine


5. Precision Medicine and Clinical Care
5. Precision medicine primarily aims to:
A. Reduce health care costs
B. Replace clinical judgment
C. Tailor care using genetic and molecular data
D. Standardize treatment
Correct Answer: C
Rationale: Precision medicine individualizes therapy based on
biological variability.
Citation: Harrison’s 22nd ed., Ch. 5 – Precision Medicine and
Clinical Care


6. Screening and Prevention of Disease
6. The most critical factor determining the value of a screening
test is: