This document features 200+ expertly verified and 100% accurate questions with answers, fully aligned with the 2026 HESI A2 Anatomy and Physiology exam. It serves as a comprehensive and structured study resource for nursing and allied health applicants preparing for program entrance exams. Each question is phrased in HESI format with straightforward, correct responses—perfect for timed practice and rapid revision.
Key concepts covered include:
Cardiovascular system (tricuspid valve, blood flow through the heart, SA node, veins vs arteries, hemoglobin, HDL, capillaries)
Nervous system (phrenic nerve, cerebrum, parasympathetic response, saltatory conduction, Wernicke’s area, neurotransmitters)
Musculoskeletal system (fibula/tibia, scapula, hinge joints, ossification, bone marrow, osteoblasts, diaphysis, cartilage)
Endocrine system and hormones (hypothalamus, pituitary, insulin, calcitonin, aldosterone, progesterone, prolactin, melatonin)
Digestive and excretory systems (bile, chyme, liver, small intestine, kidneys, nephrons, urea, hepatic portal system)
Reproductive and urinary systems (urethra, FSH, LH, estrogen, sperm production, urinary bladder)
Respiratory system (pharynx, diaphragm, tidal volume, alveoli, gas exchange, larynx)
Tissues and cell functions (epithelial, connective, nervous, muscle, phagocytosis, osmosis, cell theory, cellular respiration)
Skin and glands (epidermis layers, sebaceous and eccrine glands, stratum corneum, vitamin D synthesis)
Immune system and blood cells (plasma cells, leukocytes, macrophages, lymphocytes, neutrophils)
This guide is especially beneficial for:
HESI A2 exam candidates for 2026
Nursing, pre-nursing, or LPN/ADN applicants
Allied health students preparing for entrance or certification exams
A&P learners in high school, community college, or university courses
Keywords:
HESI A2 2026, anatomy and physiology, tricuspid valve, SA node, phrenic nerve, cerebrum, fibula, tibia, scapula, Wernicke’s area, saltatory conduction, endocrine glands, insulin, prolactin, hemoglobin, erythrocytes, alveoli, nephron, hepatic portal vein, skeletal joints, epidermis, sensory neurons, digestive system, nursing entrance exam prep
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Hesi A2 Anatomy and Physiology 2026
Exam Questions with 100% Correct
Answers | Latest Update
Tricuspid valve - 🧠ANSWER ✔✔the valve responsible for preventing the
backflow of blood from the right ventricle to the right atrium
Phrenic nerve - 🧠ANSWER ✔✔one of a pair of nerves that arises from
cervical spinal roots and passes down the thorax to innervate the
diaphragm and control breathing
Superior vena cava - 🧠ANSWER ✔✔returns blood to the heart, draining the
head, neck and upper torso
, Which two bones make up the lower leg structure? - 🧠ANSWER ✔✔Fibula
& tibia
Limbic System - 🧠ANSWER ✔✔controls basic emotions and drives
Latissimus dorsi - 🧠ANSWER ✔✔Muscle responsible for the adduction of
the shoulder.
scapula - 🧠ANSWER ✔✔Shoulder blade also categorized as a flat bone (A
flat bone is defined as a bone that provides muscular attachment and also
serves to protect the body's vital organs or sensitive areas.)
Section of the human spine that contains 5 vertebrae - 🧠ANSWER
✔✔Lumbar, the lower region of the back, numbered L1-L5
The following would be a direct result of lipid depletion in the human body -
🧠ANSWER ✔✔the decrease in the amount of estrogen produced
Fats are broken down in the small intestine using which enzyme(s)? -
🧠ANSWER ✔✔Fats also known as lipids are broken down using lipase
produced by the pancreas and bile produced by the liver but transferred to
the small intestine through the bile duct.