1
Mod7,8, Medical Biochemistry Unit 1 Exam,
Week 2 Evaluation, Pre-Evaluation Question
Bank, 1 Questions with Correct Answers |
Updated (100% Correct Answers)
Succinate is a substrate for which complex in the ETC? Answer:
Complex II
In the case of an exothermic reaction: Answer: deltaG0
(spontaneous reaction) would be negative
Last cytochrome in ETC, cytochrome oxidase, passes electrons to O2.
Cytochrome oxidase is able to do this because it has: Answer: lower
Km for oxygen then hemoglobin
The lower Km for oxygen allows cytochrome oxidase to 'pull'
oxygen from myoglobin and hemoglobin, additionally it is bound to
copper ions that allows for the collection of 4 electrons required for
the reduction of oxygen
The addition of dinitrophenol to the ETC will lead to an increase in
O2 consumption. This is an example of: Answer: uncoupler
DNP is an uncoupler of the ETC dissipating the proton gradient
across the inner mitochondrial membrane
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,2
The oxidation of double bonds is coupled to: Answer: the reduction
of FAD
Which of the following components of ETC is not bound to the
mitochondrial membrane? Answer: CoQ--mobile component, able
to accept both electrons and protons
Which is an example of mechanical work? Answer: the energy
required to change the conformation of hemoglobin
ATP is a high energy molecule that is often hydrolyzed during
reactions. The energy within ATP is stored primarily in which of the
following components of the molecule? Answer: high energy
phosphate bonds
Dinitrophenol is an uncoupler of the ETC. The addition of DNP will
have which of the following impacts? Answer: Increase oxygen
consumption
-uncoupler of ETC dissipates the proton gradient across the inner
mitochondrial membrane and increase O2 consumption
As electrons flow through complexes in the inner mitochondrial
membrane, protons are pumped from the matrix to the
intermembrane space. Which of the following statements is most
reflective of the pH in the intermembrane space? Answer: The pH is
higher in the matrix when compared to the intermembrane space
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,3
Heat can be generated in the brown adipose tissue of mammals
due to which of the following processes? Answer: uncoupling of the
ETC by thermogenin
The malate aspartate shuttle is used to move NADH from the
cytosol into the mitochondria where it can be oxidized. Which
compound is used to to move cytosolic NADS into the
mitochondria? Answer: Malate
A series of reactions the the follow deltaG:
deltaG:-1
deltaG:+3
deltaG:-5
What is the overall deltaG for the series of reactions? Answer: -3
Complex II (Succinate dehydrogenase) is not considered to be part
of the process of oxidative phosphorylation because it is unable to
do which of the following activities Answer: Pump protons from the
mitochondrial matrix to the intermembrane space
The glycerol 3-phosphate shuttle is the major shuttle of most
tissues. Which of the following best describes the transfer of
electrons by this shuttle? Answer: electrons are directly transferred
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, 4
from the glycerol 3-P to an FAD containing glycerol phosphate
dehydrogenase
The synthesis of large molecules from smaller compounds is an
example of what type of work? Answer: biochemical
Insulin stimulates fatty acid synthesis in the liver. These fatty acids
are transported to the adipose tissue as: Answer: VLDL particles
The second messenger in the signaling cascade initiated by
glucagon is: Answer: cAMP
Low blood glucose stimulates the release of ACTH which in turn
stimulates the release of: Answer: epinephrine and cortisol
All of the following stimulate the release of insulin Answer: glucose,
AA, gut Hormones (NOT EPINEPHRINE)
Insulin consists of 2 polypeptide chains that are held together
through: Answer: disulfide linkage
Insulin stimulates the following pathways Answer: glycogen
synthesis, fatty acid synthesis, glycolysis (NOT AA CATABOLISM)
The release of insulin from the beta-cells is mediated by which of
the following processes? Answer: increase in intracellular calcium
The association of DNA and histones can be modified by histone
acetylation. A decrease in histone acetylation will have which of the
© 2025 All rights reserved
Mod7,8, Medical Biochemistry Unit 1 Exam,
Week 2 Evaluation, Pre-Evaluation Question
Bank, 1 Questions with Correct Answers |
Updated (100% Correct Answers)
Succinate is a substrate for which complex in the ETC? Answer:
Complex II
In the case of an exothermic reaction: Answer: deltaG0
(spontaneous reaction) would be negative
Last cytochrome in ETC, cytochrome oxidase, passes electrons to O2.
Cytochrome oxidase is able to do this because it has: Answer: lower
Km for oxygen then hemoglobin
The lower Km for oxygen allows cytochrome oxidase to 'pull'
oxygen from myoglobin and hemoglobin, additionally it is bound to
copper ions that allows for the collection of 4 electrons required for
the reduction of oxygen
The addition of dinitrophenol to the ETC will lead to an increase in
O2 consumption. This is an example of: Answer: uncoupler
DNP is an uncoupler of the ETC dissipating the proton gradient
across the inner mitochondrial membrane
© 2025 All rights reserved
,2
The oxidation of double bonds is coupled to: Answer: the reduction
of FAD
Which of the following components of ETC is not bound to the
mitochondrial membrane? Answer: CoQ--mobile component, able
to accept both electrons and protons
Which is an example of mechanical work? Answer: the energy
required to change the conformation of hemoglobin
ATP is a high energy molecule that is often hydrolyzed during
reactions. The energy within ATP is stored primarily in which of the
following components of the molecule? Answer: high energy
phosphate bonds
Dinitrophenol is an uncoupler of the ETC. The addition of DNP will
have which of the following impacts? Answer: Increase oxygen
consumption
-uncoupler of ETC dissipates the proton gradient across the inner
mitochondrial membrane and increase O2 consumption
As electrons flow through complexes in the inner mitochondrial
membrane, protons are pumped from the matrix to the
intermembrane space. Which of the following statements is most
reflective of the pH in the intermembrane space? Answer: The pH is
higher in the matrix when compared to the intermembrane space
© 2025 All rights reserved
,3
Heat can be generated in the brown adipose tissue of mammals
due to which of the following processes? Answer: uncoupling of the
ETC by thermogenin
The malate aspartate shuttle is used to move NADH from the
cytosol into the mitochondria where it can be oxidized. Which
compound is used to to move cytosolic NADS into the
mitochondria? Answer: Malate
A series of reactions the the follow deltaG:
deltaG:-1
deltaG:+3
deltaG:-5
What is the overall deltaG for the series of reactions? Answer: -3
Complex II (Succinate dehydrogenase) is not considered to be part
of the process of oxidative phosphorylation because it is unable to
do which of the following activities Answer: Pump protons from the
mitochondrial matrix to the intermembrane space
The glycerol 3-phosphate shuttle is the major shuttle of most
tissues. Which of the following best describes the transfer of
electrons by this shuttle? Answer: electrons are directly transferred
© 2025 All rights reserved
, 4
from the glycerol 3-P to an FAD containing glycerol phosphate
dehydrogenase
The synthesis of large molecules from smaller compounds is an
example of what type of work? Answer: biochemical
Insulin stimulates fatty acid synthesis in the liver. These fatty acids
are transported to the adipose tissue as: Answer: VLDL particles
The second messenger in the signaling cascade initiated by
glucagon is: Answer: cAMP
Low blood glucose stimulates the release of ACTH which in turn
stimulates the release of: Answer: epinephrine and cortisol
All of the following stimulate the release of insulin Answer: glucose,
AA, gut Hormones (NOT EPINEPHRINE)
Insulin consists of 2 polypeptide chains that are held together
through: Answer: disulfide linkage
Insulin stimulates the following pathways Answer: glycogen
synthesis, fatty acid synthesis, glycolysis (NOT AA CATABOLISM)
The release of insulin from the beta-cells is mediated by which of
the following processes? Answer: increase in intracellular calcium
The association of DNA and histones can be modified by histone
acetylation. A decrease in histone acetylation will have which of the
© 2025 All rights reserved
