TEST BANK
Brody's Human Pharmacology, 5th Edition
by Lynn Crespo, George Dunaway
ST
U
D
YL
AB
, AB
YL
D
U
ST
,Wecker: Brody’s Human Pharmacology, 5th Edition
Chapter 01: Pharmacodynamics: Receptors and Concentration-Response Relationships
Test Bank
Multiple Choice
1. The majority of medications available today act on which superfamily of cellular
membrane receptor?
A. Ligand-gated ion channel
B. G-protein-coupled receptor
C. Receptor tyrosine kinase
ST
D. Nuclear hormone receptor
E. Cytokine receptor
ANS: B. The majority of drugs available act on G-protein-coupled receptors.
2. Nalbuphine is an effective pain reliever because of its activity at mu-opioid receptors.
U
However, if given to a patient who has recently received morphine (which also affects
mu-opioid receptors) for postoperative pain, nalbuphine can worsen his or her pain. Thus
nalbuphine is said to have what kind of activity at mu-opioid receptors?
D
A. Full agonist
B. Partial agonist
YL
C. Competitive antagonist
D. Non-competitive antagonist
E. Allosteric modifier
ANS: B. Nalbuphine is a partial agonist at opioid receptors.
AB
, Wecker: Brody’s Human Pharmacology, 5th Edition
Chapter 02: Pharmacokinetics: Absorption, Distribution, Metabolism, and Elimination
Test Bank
Multiple Choice
1. Which of the following features of a drug would enhance its uptake in the GI tract?
A. Polar
B. Water soluble
C. Ionized
D. Low molecular weight
ST
E. Low concentration gradient
ANS: D. Of the options given, only a low molecular weight will increase uptake of a
drug by the GI tract.
2. Which organ contains predominantly tight intercellular junctions, thereby restricting
U
its uptake of drugs?
A. Kidney
D
B. Liver
C. Brain
D. Heart
YL
E. Lungs
ANS: C. The brain contains tight intercellular junctions, forming the “blood-brain
barrier.”
3. Drugs commonly undergo all of the following types of metabolism in the liver
AB
EXCEPT FOR:
A. Polymerization
B. Conjugation
C. Oxidation
D. Reduction
E. Hydrolysis
ANS: A. Polymerization is not a common process by which drugs are hepatically
metabolized.
4. Which organ contains predominantly tight intercellular junctions, thereby restricting
its uptake of drugs?
A. Kidney
Brody's Human Pharmacology, 5th Edition
by Lynn Crespo, George Dunaway
ST
U
D
YL
AB
, AB
YL
D
U
ST
,Wecker: Brody’s Human Pharmacology, 5th Edition
Chapter 01: Pharmacodynamics: Receptors and Concentration-Response Relationships
Test Bank
Multiple Choice
1. The majority of medications available today act on which superfamily of cellular
membrane receptor?
A. Ligand-gated ion channel
B. G-protein-coupled receptor
C. Receptor tyrosine kinase
ST
D. Nuclear hormone receptor
E. Cytokine receptor
ANS: B. The majority of drugs available act on G-protein-coupled receptors.
2. Nalbuphine is an effective pain reliever because of its activity at mu-opioid receptors.
U
However, if given to a patient who has recently received morphine (which also affects
mu-opioid receptors) for postoperative pain, nalbuphine can worsen his or her pain. Thus
nalbuphine is said to have what kind of activity at mu-opioid receptors?
D
A. Full agonist
B. Partial agonist
YL
C. Competitive antagonist
D. Non-competitive antagonist
E. Allosteric modifier
ANS: B. Nalbuphine is a partial agonist at opioid receptors.
AB
, Wecker: Brody’s Human Pharmacology, 5th Edition
Chapter 02: Pharmacokinetics: Absorption, Distribution, Metabolism, and Elimination
Test Bank
Multiple Choice
1. Which of the following features of a drug would enhance its uptake in the GI tract?
A. Polar
B. Water soluble
C. Ionized
D. Low molecular weight
ST
E. Low concentration gradient
ANS: D. Of the options given, only a low molecular weight will increase uptake of a
drug by the GI tract.
2. Which organ contains predominantly tight intercellular junctions, thereby restricting
U
its uptake of drugs?
A. Kidney
D
B. Liver
C. Brain
D. Heart
YL
E. Lungs
ANS: C. The brain contains tight intercellular junctions, forming the “blood-brain
barrier.”
3. Drugs commonly undergo all of the following types of metabolism in the liver
AB
EXCEPT FOR:
A. Polymerization
B. Conjugation
C. Oxidation
D. Reduction
E. Hydrolysis
ANS: A. Polymerization is not a common process by which drugs are hepatically
metabolized.
4. Which organ contains predominantly tight intercellular junctions, thereby restricting
its uptake of drugs?
A. Kidney
