FCCN 2 Drugs Exam Questions with Verified Answers
Caffeine Addiction
Variations in the CYP1A2 gene also associated with increased caffeine consumption. Those with
low expression have increased risk for cardiovascular toxicity.
Do energy drinks improve reaction time?
No
Do energy drink affect alcohol pharmacokinetics?
No, you will have the same blood alcohol levels
What is the primary enzyme that breaks down cocaine?
hBChE/CocE breaks cocaine down into ecgonine methyl ester and benzoate
What is the secondary enzyme that breaks down cocaine?
hCE-1 breaks cocaine down into benzoylecgonine
When cocaine is mixed with alcohol what does hCE-1 do?
it makes MeOH and Cocaethylene which is very toxic to the body
What is the third pathway of metabolism for cocaine?
CYP3A4 which makes norcocaine
How do you make crack cocaine?
Cocaine + sodium bicarbonate + H2O; it is much cheaper than cocaine
What does cocaine do to the Monoamine Transporter?
, It inhibits the monoamine transporter and this causes the euphoric effects. Monoamine mainly
affects dopamine, then NE and serotonin. It has the largest binding affinity to DAT.
What does cocaine do on the neuronal level?
It blocks the dopamine transporter, which inhibits it from being broken down or repackaged by
VMAT
What do D1 receptors do to the Cocaine reward?
D1 receptors mediate cocaine reward, so D1 antagonists blunt the effect of cocaine.
How do AMPA antagonists effect motor activity when a subject is given cocaine?
It decreases motor activity a lot- a lot more than D1 antagonists.
What is raclopride?
DA receptor antagonist; normally raclopride is high in the brain and dopamine is low. When
people use cocaine, they have low raclopride and high dopamine.
What do Fos Proteins do?
They modulate cellular proliferation, differentiation, and transformation. c-Fos proteins are
associated with neuronal activity.
What does deltaFosB do in chronic cocaine use?
It has an important role in the development of addiction, the amount of this protein increases
when there is increased dopamine binding during chronic cocaine use.
What does deltaFosB do in acute cocaine use?
There is a steady rise of deltaFosB over 12 hours, but it is mostly plateaued. c-Fos increases and
decreases over 6 hours, and then other acute Fos Proteins increase and decrease over 12 hours.
What does BDNF do when cocaine is administered?
Caffeine Addiction
Variations in the CYP1A2 gene also associated with increased caffeine consumption. Those with
low expression have increased risk for cardiovascular toxicity.
Do energy drinks improve reaction time?
No
Do energy drink affect alcohol pharmacokinetics?
No, you will have the same blood alcohol levels
What is the primary enzyme that breaks down cocaine?
hBChE/CocE breaks cocaine down into ecgonine methyl ester and benzoate
What is the secondary enzyme that breaks down cocaine?
hCE-1 breaks cocaine down into benzoylecgonine
When cocaine is mixed with alcohol what does hCE-1 do?
it makes MeOH and Cocaethylene which is very toxic to the body
What is the third pathway of metabolism for cocaine?
CYP3A4 which makes norcocaine
How do you make crack cocaine?
Cocaine + sodium bicarbonate + H2O; it is much cheaper than cocaine
What does cocaine do to the Monoamine Transporter?
, It inhibits the monoamine transporter and this causes the euphoric effects. Monoamine mainly
affects dopamine, then NE and serotonin. It has the largest binding affinity to DAT.
What does cocaine do on the neuronal level?
It blocks the dopamine transporter, which inhibits it from being broken down or repackaged by
VMAT
What do D1 receptors do to the Cocaine reward?
D1 receptors mediate cocaine reward, so D1 antagonists blunt the effect of cocaine.
How do AMPA antagonists effect motor activity when a subject is given cocaine?
It decreases motor activity a lot- a lot more than D1 antagonists.
What is raclopride?
DA receptor antagonist; normally raclopride is high in the brain and dopamine is low. When
people use cocaine, they have low raclopride and high dopamine.
What do Fos Proteins do?
They modulate cellular proliferation, differentiation, and transformation. c-Fos proteins are
associated with neuronal activity.
What does deltaFosB do in chronic cocaine use?
It has an important role in the development of addiction, the amount of this protein increases
when there is increased dopamine binding during chronic cocaine use.
What does deltaFosB do in acute cocaine use?
There is a steady rise of deltaFosB over 12 hours, but it is mostly plateaued. c-Fos increases and
decreases over 6 hours, and then other acute Fos Proteins increase and decrease over 12 hours.
What does BDNF do when cocaine is administered?
