GUIDE
FOR THE CARE AND USE OF
LABORATORY ANIMALS
Eighth Edition
, Contents
1 Key concepts 1
Applicability and goals, 2
Intended audiences and uses of the guide, 3 et
hics and animal use, 4
The threejrs, 4
Key terms used in the guide, 5 human
ejcare, 6
Animal care and usejprogram, 6
Engineering, performance, andjpractice standards, 6 polic
ies, principles, and procedures, 7
Must, should, and may, 8 refe
rences, 8
2 Animal care and use program 11
Regulations, policies, and principles, 12 progra
m management, 13
Program management responsibility, 13 th
ejinstitutional official, 13
The attending veterinarian, 14
Thejinstitutional animaljcare and usejcommittee, 14 collaboratio
ns, 15
Personnel management, 15 traini
ng and education, 15
Occupational health and safety of personnel, 17
Xxi
,Xxii contents
Personnel security, 23
Investigating and reporting animal welfare concerns, 23 prog
ram oversight, 24
The rolejof the iacuc, 24
Iacuc constitution and function, 24jpr
otocol review, 25
Special considerations for iacuc review, 27 postap
proval monitoring, 33
Disaster planning and emergency preparedness, 35 referenc
es, 35
3 Environment, housing, and management 41
Terrestrialjanimals, 42
Terrestrial environment, 42
Microenvironment and macroenvironment, 42 temp
erature and humidity, 43
Ventilation and air quality, 45
illumination, 47
Noise and vibration, 49 terres
trial housing, 50
Microenvironment (primary enclosure), 50jenvironm
ental enrichment, 52
Sheltered or outdoor housing, 54 natu
ralistic environments, 55
Space, 55
Terrestrialjmanagement, 63
Behavioral and social management, 63 husbandry
, 65
Population management, 75
Aquatic animals, 77
Aquaticjenvironment, 77
Microenvironment and macroenvironment, 77 wa
ter quality, 78
Life support system, 79
Temperature, humidity, and ventilation, 80jilluminati
on, 81
Noise and vibration, 81 aquati
c housing, 82
Microenvironment (primary enclosure), 82 environ
mental enrichment and social housing, 82 sheltered
, outdoor, and naturalistic housing, 83 space, 83
, Contents xxiii
Aquatic management, 84
Behavior and social management, 84jhusbandry
, 84
Population management, 87
References, 88
4 Veterinary care 105
Animaljprocurementjand transportation, 106jan
imal procurement, 106
Transportation of animals, 107 pre
ventive medicine, 109
Animal biosecurity, 109 quarantin
ejand stabilization, 110
Separation by health statusjandjspecies, 111
Surveillance, diagnosis, treatment, and control of disease, 112 clinica l
care and management, 113
Medical management, 114
Emergency care, 114
Recordkeeping, 115
Surgery, 115
Training, 115
Presurgical planning, 116
Surgicaljfacilities, 116
Surgicaljprocedures, 117
Asepticjtechnique, 118
Intraoperativejmonitoring, 119
postoperative care, 119 p
Ain and distress, 120 anesthes
ia and analgesia, 121 euthanas
ia, 123
References, 124
5 Physical plant 133
General considerations, 133
Location, 134
Centralization versus decentralization, 134 function
al areas, 135
Construction guidelines, 136
Corridors, 136
Animal room doors, 137 e
xteriorjwindows, 137
Floors, 137
FOR THE CARE AND USE OF
LABORATORY ANIMALS
Eighth Edition
, Contents
1 Key concepts 1
Applicability and goals, 2
Intended audiences and uses of the guide, 3 et
hics and animal use, 4
The threejrs, 4
Key terms used in the guide, 5 human
ejcare, 6
Animal care and usejprogram, 6
Engineering, performance, andjpractice standards, 6 polic
ies, principles, and procedures, 7
Must, should, and may, 8 refe
rences, 8
2 Animal care and use program 11
Regulations, policies, and principles, 12 progra
m management, 13
Program management responsibility, 13 th
ejinstitutional official, 13
The attending veterinarian, 14
Thejinstitutional animaljcare and usejcommittee, 14 collaboratio
ns, 15
Personnel management, 15 traini
ng and education, 15
Occupational health and safety of personnel, 17
Xxi
,Xxii contents
Personnel security, 23
Investigating and reporting animal welfare concerns, 23 prog
ram oversight, 24
The rolejof the iacuc, 24
Iacuc constitution and function, 24jpr
otocol review, 25
Special considerations for iacuc review, 27 postap
proval monitoring, 33
Disaster planning and emergency preparedness, 35 referenc
es, 35
3 Environment, housing, and management 41
Terrestrialjanimals, 42
Terrestrial environment, 42
Microenvironment and macroenvironment, 42 temp
erature and humidity, 43
Ventilation and air quality, 45
illumination, 47
Noise and vibration, 49 terres
trial housing, 50
Microenvironment (primary enclosure), 50jenvironm
ental enrichment, 52
Sheltered or outdoor housing, 54 natu
ralistic environments, 55
Space, 55
Terrestrialjmanagement, 63
Behavioral and social management, 63 husbandry
, 65
Population management, 75
Aquatic animals, 77
Aquaticjenvironment, 77
Microenvironment and macroenvironment, 77 wa
ter quality, 78
Life support system, 79
Temperature, humidity, and ventilation, 80jilluminati
on, 81
Noise and vibration, 81 aquati
c housing, 82
Microenvironment (primary enclosure), 82 environ
mental enrichment and social housing, 82 sheltered
, outdoor, and naturalistic housing, 83 space, 83
, Contents xxiii
Aquatic management, 84
Behavior and social management, 84jhusbandry
, 84
Population management, 87
References, 88
4 Veterinary care 105
Animaljprocurementjand transportation, 106jan
imal procurement, 106
Transportation of animals, 107 pre
ventive medicine, 109
Animal biosecurity, 109 quarantin
ejand stabilization, 110
Separation by health statusjandjspecies, 111
Surveillance, diagnosis, treatment, and control of disease, 112 clinica l
care and management, 113
Medical management, 114
Emergency care, 114
Recordkeeping, 115
Surgery, 115
Training, 115
Presurgical planning, 116
Surgicaljfacilities, 116
Surgicaljprocedures, 117
Asepticjtechnique, 118
Intraoperativejmonitoring, 119
postoperative care, 119 p
Ain and distress, 120 anesthes
ia and analgesia, 121 euthanas
ia, 123
References, 124
5 Physical plant 133
General considerations, 133
Location, 134
Centralization versus decentralization, 134 function
al areas, 135
Construction guidelines, 136
Corridors, 136
Animal room doors, 137 e
xteriorjwindows, 137
Floors, 137
