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Summary Neurology - Syndromes & Diseases

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Notes on neurology syndromes and diseases

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NELROLOGICAL SYNDROMES DISEASE LEVEL OF UMN LESION
>
-


leg affected :
11 or above


>
-
arm affected =
C3 or above



"VASCULAR DISEASE
Lintharain
>
-
face affected =
pons or above

or spinal
(STROKE OR TIA) >
-

diplopia = midbrain or above

-
transient isshemic attask (TIA) is an episode of facal neurological
DEFINITIONS disturbance attributable to a transient vascular occlusion without ,
J
-

spasticity -> occurs because of destruction of evidence of a stroke on
imaging CALISES Of CEREBRAL EMBOLISM
the corticoreticulospinal tract resulting in , doesn't usually last larger than an hour or 2
>
-




Stretch reflex hyperactivity -

lesions in the territory of the internal sarotid artery result in >
-
atrial fibrillation
-

monaplegia > paralysis affecting only 1 limb
-

,
hemiplegia on the apposite side of the body if a large area of the >
-
carotid atheroma
When there is a motor cartex/ partial internal internal capsule of hemisphere is involved cortis arch atheroma
>
-




capsule lesion -
stenasis of the internal carotid artery in the neck may be associated >
-


patent foramen audie or strial septal defect sparadoxical embolus
-


hemiplegia -> affects are side of the body with a bruit from venoussystem)
Owing to a lesion affecting projection of -


haemorrhagic stookes often involve the internal capsule putamen
-
cerebral abscesses mysatis aneurysms may also sause hemiplegia
pathways from the contralateral motor cortex (sansing santralateral hemiparesis often sensory lass)
a or the
-


paraplegia > affects both legs whereas
-

,
thalamus /sausing a contralateral hemianaesthesial

&uadriplegia affects all 4 limbs 3 is the lesians in the territory of the vertebrabasilar artery may produce
-




result of spinal cord trauma or , less after , a cranial nerve palsies Cerebellar signs Hooner syndrome 3 sensory loss
, .
,


. basilar sirtery thrombosis/
brainstem lesion Se g . as well as UMN signs (often bilateral because of close proximity of
structures in the brainster)



·
LATERAL MEDLILLARY SYNDROME
INFECTION (WALLENBERG SYNDROME)
-

HIV is an importantsause of -
this syndrome demonstrates the importance of examining pain 3
neurological problems including , temperature rather than light taush
LI MN syndromes
L
-
occlusion of the posterior inferior cerebellar or lateral
vertebral
or

medullary arteries ipsilateral' crossed' neurological signs
causes :




DEMYELINATING DISEASE signs (ipsilateral)
> carebellar
-




> Horner's
-


syndrome Sipsilateral)
>
-
lower cranial nerves /IX X)- Palate is vocal cord weakness
.
ANATOMY OF THE CIRCLE OF WILLIS
-

multiple sclerosis SMS) results in lesians in different lipsilateral)
sensoryloss of painipsilateralla lateral)
relapsing
> facial
areas , usually with a is remitting course
-




>
-
na UMN weakness



J




COMPRESSIVE BINFILTRATIVE LESIONS
in the lobes of the brain focal signs will depend a
Tumourstendto
-
occur in


-

signs localised to the parietal temporal occipital
, , or frontal lobe suggest
this disease process
may be false localising signs in the presence of 41P
-




2 g a unilateral or bilateral 6th [N palsy
>
-
. .




-

Papilloedema is usuallyassociated if there is ↑1P




LMLSON wasting ,
ex arc

recused/absent reflexes 3 sometimes
3 : cause musale


- asciculations
-
results from a lesion of the spinal motor neurons
,


mator root or peripheral nerve

, ·
MONONEURITIS MULTIPLEX
DEFINITION


LNERVES refers to the separate involvement of >1
-



-
often cranial) nerve by a
peripheral for less
-
if there is evidence of a peripheral nerve lesion peripheral ,
neuropathy single disease
or a mononeuritis multiplex palpate for thiskened nerves
,

>
-
Median nervs at wrist , ulnar nerve at elbow , greater auricular
in the neck nerve at the head of the
A CLITE CALISES (USUALLY VASCULARI
nerve common peroneal
fibula are the most easily accessible -
7
polyarteritis nadosa
-
if nerves are thickened , consider the following diagnoses : >
-
diabetes mellitus
>
-

acromegaly >
-
connective tissue disease Je g . . rheumatoid
>
-

amyloidosis arthritis , systemis lupus erythematosus)
>
-
shronis inflammatory demyelinating polyradiculoneuropathy
CHRONIC SAUSES
>
-

leprosy
>
-

hereditary motor 3 sensory neuropathy >
-

multiple compressive neuropathies
>
-
other (e g
. . sarcoidosis , diabetes mellitus , neurafibromatosis) >
-
sarcoidosis
>
-

asromegaly
>
-
HIV infection
>
-

leprasy
> lyme disease
-




>
-
others /e g . . Carcinoma-rarel

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January 12, 2026
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