PCB 3233 - Immunology Exam 3 Chapter 5 and 6
Questions and Correct Answers (verified
answers) | Graded A+ | New Update 2025 |
University of Central Florida
Helper T cells associate with which class of MHC molecules? - ANSWERS MHC
Class 2 (extracellular infection)
BCR (B cell receptor) and TCR (T cell receptor), how are they created and where in
the body are they created? - ANSWERS As a result of Gene Arrangement (VDJ
Somatic Recombination).
- BCR: produced in Bone Marrow
- TCR: produced in Thymus
Interferon function - ANSWERS Viral fighting, they activate NK cells which then
tell our infected cells to die by apoptosis.
BCR and TCR how are they created? - ANSWERS somatic recombination - gene
rearrangement = sequence variability in V regions (bone marrow vs. thymus)
What process creates the variable region domain for both TCRs and BCRs? -
ANSWERS Somatic Recombination
Structure of immunoglobulin and the T cell receptor (TCR)? - ANSWERS Ig:
- Ig = Heavy and light chains, Fab and Fc regions, 4 polypeptide chains, secreted.
,TCR:
- (alpha) chain and (beta) chain each with variability and constant region.
- TCR = α and β chains, 2 polypeptide chains, CD3 complex (4 proteins for
signaling), 2 zeta chains, transmembrane.
Each chain has a variable and a constant region
What the different types IFN-1? - ANSWERS Alpha and Beta
structure of immunoglobulin and the TCR - ANSWERS a. BCR: 4 polypeptide
chain with a and b for signalling on the surface of a B cell
b. Domain structure of TCR is similar to lg
c. TCR: 2 polypeptide, CD3 complex (4 proteins for signaling), and 2 zeta chains
d. each chain has variable region and constant region
What are the differences and similarities between CD8 T Cells and NK cells? -
ANSWERS The both have the same cytotoxic granules, NK cells are activated
faster, because they come out of the bone marrow "ready to go". CD8 T cells
recognizes MHC Class 1 + peptide (antigen) on a pathogen, while NK cells
recognize normal MHC Class 1 molecules on the surface of our cells and activating
ligands that infected cells put up on their surface.
The T cell receptor *(TCR) type of antigen* vs. Ig (BCR) type of antigen?
a) TCR - ANSWERS TCR:
- bind to peptide antigens which are derived from the pathogen's proteins.
,- It requires presentation by MHC molecules.
- Cells bind one type of antigen which must be presented to them on the surface
of another human cell.
2 types of activating ligands - ANSWERS MIC - A and MIC - B, they bind to
activating receptors on activating NK cells
The TCR type of antigen vs. lg type of antigen. - ANSWERS a. TCR only found
on the surface of their t cells; multipoint attachement; multiple copies of TCR bind
to multiple copies of antigen (MHC complex on opposing cell)
b. BCR can be secreted in the form of an antibody; bind epitopes on intact
molecules
Type 2 interferon - ANSWERS Also know as IFN- gamma, activates
macrophages
The T cell receptor (TCR) type of antigen vs. *Ig (BCR) type of antigen*?
b) BCR - ANSWERS BCR:
- bind intact molecules and DO NOT require presentation.
- bind to proteins/carbohydrates/lipids on the surfaces of pathogens.
IL - 12 - ANSWERS Inflammatory cytokine that activates NK cells which then
produces IFN - gamma which then activate macrophages.
Function of a TCR. - ANSWERS a. used only to recognize antigens
, b. TCR membrane bound glycoprotein: recognize cell-to-cell contact.
Which complement receptors can recognize C3b? - ANSWERS CR 1 - CR 4
For expression of the TCR at the cell surface what is needed?
(list all proteins and the name given to all the proteins and TCR when on the
surface) - ANSWERS - needs the CD3 complex (Chr 11, homologous CD3
gamma, CD3 delta, & CD3 Epsilon)
- needs a zeta chain
Which Professional Antigen Presenting Cell (Professional - APC) is strong enough
to activate a CD8 T cell from a naive state? - ANSWERS Dendritic cells
What is a TCR complex? - ANSWERS a. all 8 polypeptides
b. aB chains from core; stable association w/4 invariant membrane proteins
c. z chain and CD3 complex interact w/intracellular signaling transduction.
i. lack of CD3δ in CD3ε = low expression and impaired signal transduction
C3 convertase of the Alternative Pathway - ANSWERS C3bBb
Function of a T cell receptor (TCR); TCR complex. - ANSWERS Function of a
TCR:
- is to recognize MHC bound Ag's.
- used only to recognize antigens (not effectors themselves.
TCR Complex:
Questions and Correct Answers (verified
answers) | Graded A+ | New Update 2025 |
University of Central Florida
Helper T cells associate with which class of MHC molecules? - ANSWERS MHC
Class 2 (extracellular infection)
BCR (B cell receptor) and TCR (T cell receptor), how are they created and where in
the body are they created? - ANSWERS As a result of Gene Arrangement (VDJ
Somatic Recombination).
- BCR: produced in Bone Marrow
- TCR: produced in Thymus
Interferon function - ANSWERS Viral fighting, they activate NK cells which then
tell our infected cells to die by apoptosis.
BCR and TCR how are they created? - ANSWERS somatic recombination - gene
rearrangement = sequence variability in V regions (bone marrow vs. thymus)
What process creates the variable region domain for both TCRs and BCRs? -
ANSWERS Somatic Recombination
Structure of immunoglobulin and the T cell receptor (TCR)? - ANSWERS Ig:
- Ig = Heavy and light chains, Fab and Fc regions, 4 polypeptide chains, secreted.
,TCR:
- (alpha) chain and (beta) chain each with variability and constant region.
- TCR = α and β chains, 2 polypeptide chains, CD3 complex (4 proteins for
signaling), 2 zeta chains, transmembrane.
Each chain has a variable and a constant region
What the different types IFN-1? - ANSWERS Alpha and Beta
structure of immunoglobulin and the TCR - ANSWERS a. BCR: 4 polypeptide
chain with a and b for signalling on the surface of a B cell
b. Domain structure of TCR is similar to lg
c. TCR: 2 polypeptide, CD3 complex (4 proteins for signaling), and 2 zeta chains
d. each chain has variable region and constant region
What are the differences and similarities between CD8 T Cells and NK cells? -
ANSWERS The both have the same cytotoxic granules, NK cells are activated
faster, because they come out of the bone marrow "ready to go". CD8 T cells
recognizes MHC Class 1 + peptide (antigen) on a pathogen, while NK cells
recognize normal MHC Class 1 molecules on the surface of our cells and activating
ligands that infected cells put up on their surface.
The T cell receptor *(TCR) type of antigen* vs. Ig (BCR) type of antigen?
a) TCR - ANSWERS TCR:
- bind to peptide antigens which are derived from the pathogen's proteins.
,- It requires presentation by MHC molecules.
- Cells bind one type of antigen which must be presented to them on the surface
of another human cell.
2 types of activating ligands - ANSWERS MIC - A and MIC - B, they bind to
activating receptors on activating NK cells
The TCR type of antigen vs. lg type of antigen. - ANSWERS a. TCR only found
on the surface of their t cells; multipoint attachement; multiple copies of TCR bind
to multiple copies of antigen (MHC complex on opposing cell)
b. BCR can be secreted in the form of an antibody; bind epitopes on intact
molecules
Type 2 interferon - ANSWERS Also know as IFN- gamma, activates
macrophages
The T cell receptor (TCR) type of antigen vs. *Ig (BCR) type of antigen*?
b) BCR - ANSWERS BCR:
- bind intact molecules and DO NOT require presentation.
- bind to proteins/carbohydrates/lipids on the surfaces of pathogens.
IL - 12 - ANSWERS Inflammatory cytokine that activates NK cells which then
produces IFN - gamma which then activate macrophages.
Function of a TCR. - ANSWERS a. used only to recognize antigens
, b. TCR membrane bound glycoprotein: recognize cell-to-cell contact.
Which complement receptors can recognize C3b? - ANSWERS CR 1 - CR 4
For expression of the TCR at the cell surface what is needed?
(list all proteins and the name given to all the proteins and TCR when on the
surface) - ANSWERS - needs the CD3 complex (Chr 11, homologous CD3
gamma, CD3 delta, & CD3 Epsilon)
- needs a zeta chain
Which Professional Antigen Presenting Cell (Professional - APC) is strong enough
to activate a CD8 T cell from a naive state? - ANSWERS Dendritic cells
What is a TCR complex? - ANSWERS a. all 8 polypeptides
b. aB chains from core; stable association w/4 invariant membrane proteins
c. z chain and CD3 complex interact w/intracellular signaling transduction.
i. lack of CD3δ in CD3ε = low expression and impaired signal transduction
C3 convertase of the Alternative Pathway - ANSWERS C3bBb
Function of a T cell receptor (TCR); TCR complex. - ANSWERS Function of a
TCR:
- is to recognize MHC bound Ag's.
- used only to recognize antigens (not effectors themselves.
TCR Complex:
