FUNDAMENTALS OF BIOCHEMISTRY LIFE AT THE
LIFE
AT
, THE MOLECULAR
LEVEL
TABLES OF Contents
1 Introduction to the Chemistry of Life 1
2 Water 9
3 Nucleotides, Nucleic Acids, and Genetic Information 21
4 Amino Acids 29
5 Proteins: Primary Structure 40
6 Proteins: Three-Dimensional Structure 49
7 Protein Function: Myoglobin and Hemoglobin, Muscle
Contraction, and Antibodies 60
8 Carbohydrates 72
9 Lipids and Biological Membranes 80
10 Membrane Transport 90
11 Enzymatic Catalysis 96
12 Enzyme Kinetics, Inhibition, and Control 108
,13 Biochemical Signaling 121
14 Introduction to Metabolism 128
15 Glucose Catabolism 137
16 Glycogen Metabolism and Gluconeogenesis 146
17 Citric Acid Cycle 154
18 Electron Transport and Oxidative Phosphorylation 160
, 19 Photosynthesis 169
20 Lipid Metabolism 176
21 Amino Acid Metabolism 188
22 Mammalian Fuel Metabolism: Integration and Regulation 197
23 Nucleotide Metabolism 203
24 Nucleic Acid Structure 210
25 DNA Replication, Repair, and Recombination 219
26 Transcription and RNA Processing 230
27 Protein Synthesis 238
28 Regulation of Gene Expression 247
Answers to Questions AQ-1
Solutions to Problems SP-1
LIFE
AT
, THE MOLECULAR
LEVEL
TABLES OF Contents
1 Introduction to the Chemistry of Life 1
2 Water 9
3 Nucleotides, Nucleic Acids, and Genetic Information 21
4 Amino Acids 29
5 Proteins: Primary Structure 40
6 Proteins: Three-Dimensional Structure 49
7 Protein Function: Myoglobin and Hemoglobin, Muscle
Contraction, and Antibodies 60
8 Carbohydrates 72
9 Lipids and Biological Membranes 80
10 Membrane Transport 90
11 Enzymatic Catalysis 96
12 Enzyme Kinetics, Inhibition, and Control 108
,13 Biochemical Signaling 121
14 Introduction to Metabolism 128
15 Glucose Catabolism 137
16 Glycogen Metabolism and Gluconeogenesis 146
17 Citric Acid Cycle 154
18 Electron Transport and Oxidative Phosphorylation 160
, 19 Photosynthesis 169
20 Lipid Metabolism 176
21 Amino Acid Metabolism 188
22 Mammalian Fuel Metabolism: Integration and Regulation 197
23 Nucleotide Metabolism 203
24 Nucleic Acid Structure 210
25 DNA Replication, Repair, and Recombination 219
26 Transcription and RNA Processing 230
27 Protein Synthesis 238
28 Regulation of Gene Expression 247
Answers to Questions AQ-1
Solutions to Problems SP-1
