Genetics Essentials: Concepts and Connections 5th Edition by
k k k k k k k
Benjamin A. Pierce
k k
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,TABLEkOFkCONTENT
Chapterk01:kIntroductionktokGenetics....................................................................................................................... 3
Chapterk02:kChromosomeskandkCellularkReproduction ......................................................................................... 15
Chapterk03:kBasickPrincipleskofkHeredity .............................................................................................................. 32
Chapterk04:kExtensionskandkModificationskofkBasickPrinciples ............................................................................ 59
Chapterk05:kLinkage,kRecombination,kandkEukaryotickGenekMapping ................................................................ 98
Chapterk06:kChromosomekVariation .................................................................................................................... 115
Chapterk07:kBacterialkandkViralkGenetickSystems ............................................................................................... 139
Chapterk08kDNA:kThekChemicalkNaturekofkthekGene ......................................................................................... 152
Chapterk09:kDNAkReplicationkandkRecombination ............................................................................................. 181
Chapterk10:kFromkDNAktokProteins:kTranscriptionkandkRNAkProcessing .......................................................... 198
Chapterk11:kFromkDNAktokProteins:kTranslation ................................................................................................ 224
Chapterk12:kControlkofkGenekExpression............................................................................................................. 244
Chapterk13:kGenekMutations,kTransposablekElements,kandkDNAkRepair ........................................................... 278
Chapterk14:kMolecularkGenetickAnalysiskandkBiotechnology ............................................................................. 298
Chapterk15:kGenomicskandkProteomics ............................................................................................................... 314
Chapterk16:kCancerkGenetics ............................................................................................................................... 332
Chapterk17:kQuantitativekGenetics ....................................................................................................................... 346
Chapterk18:kPopulationkandkEvolutionarykGenetics ............................................................................................ 366
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,Chapterk01:kIntroductionktokGenetics
1. Albinismkiskrarekinkmostkhumankpopulations,koccurringkatkakfrequencykofkaboutk1kink20,000kpeople.kHoweve
r,kthektraitkoccurskatkakfrequencykofk1kink200kinkcertainkHopikvillageskofkBlackkMesakinkArizona.kExplainkinkter
mskofknaturalkselectionkwhykalbinismkisksokrarekinkmostkhumankpopulations.
ANSWER:kInkmostkpopulations,ktherekiskfairlykstrongkselectionkagainstkalbinismkbecausekalbinoskdon’tkproducek
melanin,kcausingktheirkskinkcellsknotktokbekprotectedkfromkthekdamagingkeffectskofksunlight.kAlso,kth
eklackkofkmelaninkinktheirkeyeskcauseskthemktokhavekpoorkeyesight.kFinally,kinkmostkcultureskalbinos
karekseenkaskabnormal,kandktheykareknotknormallyksoughtkoutkforkmarriagekandkmating.kTherefore,kin
kmostkpopulationskthekalleleskthatkcausekalbinismkarekselectedkagainst,kandktheykdecreasekinkfrequenc
ykorkarekkeptkatkaklowklevel,kcausingkthekrecessivektraitktokbekrare.
2. Albinismkiskrarekinkmostkhumankpopulations,koccurringkatkakfrequencykofkaboutk1kink20,000kpeople.kHoweve
r,kthektraitkoccurskatkakfrequencykofk1kink200kinkcertainkHopikvillageskofkBlackkMesakinkArizona.kExplainkinkter
mskofknaturalkselectionkwhykthektraitkisksokmuchkmorekcommonkamongkthekHopiskofkBlackkMesa.
ANSWER:kAlbinoskoccupykakprivilegedkpositionkamongkthekHopiskofkBlackkMesa.kInkthiskculture,kalbinoskar
ekviewedkaskespeciallykpretty,kclean,kandkintelligent,kandktheykoftenkoccupykpositionskofkleadersh
ip.kAlbinoskarekcelebratedkinkthekvillageskaskaksignkofkpuritykofkHopikbloodkinkthekcommunity.
Furthermore,kalbinoskarekoftenkexcusedkfromknormalkmalekfieldklaborkbecausekofktheirksensitivitykto
ksunlight,kcausingkthemktokbekleftkbehindkinkthekvillagekwithkthekwomenkduringkthekdaytime.kThiskal
lowskthemkextrakmatingkopportunitieskcomparedktokthekotherkmenkofkthekvillage.kTherefore,kthekalle
leskthatkcausekalbinismkarekeitherkselectedkforkinkthiskculturekorkatkleastknotkselectedkagainstkaskstron
glykaskinkotherkcultures,kallowingkthektraitktokoccurkatkakmuchkhigherkfrequency.
3. Whichkonekofkthekfollowingkpairingskbetweenktheksubdisciplinekofkgeneticskandkthekphenomenonki
skINCORRECT?
a. evolution—populationkgenetics
b. genekregulation—molecularkgenetics
c. allelickfrequencykalteration—populationkgenetics
d. arrangementkofkgeneskonkchromosome—transmissionkgenetics
e. chemicalknaturekofkthekgene—transmissionkgenetics
ANSWER:ke
4. Whichkonekofkthekfollowingktopicskofkresearchkbelongsktokthekdisciplinekofktransmissionkgenetics?
a. inheritancekpatternkofkgenekalleles
b. mechanismkofkDNAkreplication
c. genekexpressionkpatterns
d. evolution
e. chemicalkmodificationkofknucleickacids
ANSWER:ka
5. Thekcompletekgenetickmakeupkofkankorganismkiskreferredktokaskits
a. chromosome.
b. alleles.
c. locus.
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, d. genome.
e. phenotype.
ANSWER:kd
6. IdentifykakTRUEkstatementkfromkthekfollowingkdescriptionskconcerningkgenetics.
a. Thektheorykofkpangenesiskstateskthatkallklivingkorganismskarekcomposedkofkcells.
b. Bacteriakandkviruseskareknotkusefulkinkstudyingkgeneskandkinheritancekbecausektheykarekstructurall
ykandkmetabolicallykdifferentkfromkeukaryotickcells.
c. CharleskDarwinkaccuratelykdescribedktheklawskofkinheritancekinkhisklandmarkkbook,kOnkthekOrigink
ofkSpecies.
d. Manykhumanktraits,ksuchkaskskinkandkhairkcolor,karekdeterminedkbykmorekthankaksinglekgene.
e. Evolutionkcankoccurkwithoutkgenetickchangeskinkthekpopulation.
ANSWER:kd
7. IdentifykakFALSEkstatementkfromkthekfollowingkdescriptionskofkgenetics.
a. Humanskfirstkappliedkgeneticsktokthekdomesticationkofkplantskandkanimalskbetweenkapproximatel
yk10,000kandk12,000kyearskago.
b. SomekviruseskusekRNAktokcarryktheirkgenetickinformation.
c. Albinismkresultskfromkakmutationkinkthekgeneskthatkcontrolktheksynthesiskandkstoragekofkmelanin.
d. Allkhumanktraitskthatkdisplaykblendingkinheritancekarekaffectedkbykaksinglekgene.
e. Thekprocesskbykwhichkgenetickinformationkiskcopiedkandkdecodedkisksimilarkforkallkformskofklife.
ANSWER:kd
8. Whichkofkthekfollowingkspecieskiskconsideredkakmodelkgenetickorganism?
a. thekplantkLinariakvulgaris
b. thekdeerkmousekPeromyscuskmaniculatus
c. thekwormkCaenorhabditiskelegans
d. thekfrogkHylakchrysoscelis
e. thekchimpanzeekPanktroglodytes
kANSWER:kc
9. WhichkofkthekfollowingkwouldkservekthekLEASTkwellkaskakmodelkforkunderstandingkbasickmechanismsk
ofkinheritance?
a. fruitkflies
b. humans
c. yeast
d. mice
e. zebrafish
ANSWER:kb
10. WhichkofkthekfollowingkstatementskiskTRUE?
a. Eachksubdisciplinekofkgeneticskiskverykspecifickasktokwhatkiskexploredkandkdoesknotkoverlapkwithkthe
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