Immunodeficiency and Autoimmunity: Practice Questions and Key
Concepts, Exams of Public Health
What is autoimmunity? - ANSWERA complex condition where the immune
system loses its ability to distinguish "self" from "non-self" leading to a
misguided immune response agains the body's own components
Most autoimmune diseases are due to defects in what genes? -
ANSWERMHC-associated genes
What are immune-privileged sites? - ANSWEROften targets of autoimmune
attack
Shielded from active immune system
Lack/minimal lymphatic drainage
Surrounded by tissue barrier: BBB, BRB
High levels of soluble anti-inflammatory molecules such as TGF-β, IL-10
Induce strong regulatory T cell responses
Examples of immunologically privileged sites - ANSWERBrain
Eye
Testis
Concepts, Exams of Public Health
What is autoimmunity? - ANSWERA complex condition where the immune
system loses its ability to distinguish "self" from "non-self" leading to a
misguided immune response agains the body's own components
Most autoimmune diseases are due to defects in what genes? -
ANSWERMHC-associated genes
What are immune-privileged sites? - ANSWEROften targets of autoimmune
attack
Shielded from active immune system
Lack/minimal lymphatic drainage
Surrounded by tissue barrier: BBB, BRB
High levels of soluble anti-inflammatory molecules such as TGF-β, IL-10
Induce strong regulatory T cell responses
Examples of immunologically privileged sites - ANSWERBrain
Eye
Testis
