1
WGU D116 Unit 8 OA Review Questions with Answers
(100% Correct Answers)
A nursing student asks for clarification on the differences between the
mechanisms of spontaneous mutation and conjugation in acquired
resistance of microbes.
Which statement is correct? Answer: Spontaneous mutation leads to
resistance to only one antimicrobial agent
A patient receiving a cephalosporin develops a secondary intestinal
infection caused by Clostridium difficile.
What is an appropriate treatment for this patient? Answer:
Discontinuing the cephalosporin and beginning flagyl
A patient is diagnosed with a lung infection caused by Pseudomonas
aeruginosa. The culture and sensitivity report shows sensitivity to all
aminoglycosides. The provider knows that the rate of resistance to
gentamicin is common in this hospital.
Which medication should the provider be expected to order? Answer:
Amikacin
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,2
When resistance to gentamicin and tobramycin is common, amikacin is
the drug of choice for the initial treatment of aminoglycoside-sensitive
infections
A child with otitis media has had three ear infections in the past year.
The child has just completed a ten-day course of amoxicillin with no
improvement. The parent asks the provider why this drug is not
working because it has worked in the past.
What should the provider tell the patient? Answer: "The bacteria have
synthesized penicillinase"
Beta-lactamases are enzymes that cleave the beta-lactam ring and
render the PCN inactive (amoxicillin)
Pt will need to start augmentin
A patient who is taking acetaminophen for pain wants to know why it
does not cause gastrointestinal upset as other over-the-counter pain
medications do.
Which property of acetaminophen is the most likely explanation for
this? Answer: It has minimal effects at peripheral sites
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, 3
Tylenol central effects
NSAIDs peripheral effects
A patient who has arthritis has been taking ibuprofen and a
glucocorticoid medication. The patient reports having tarry stools but
denies gastric pain.
Which action by the provider is correct? Answer: Prescribing an
antiulcer medication
Glucocorticoid therapy, especially when combined with NSAIDs, can
increase the risk of gastric ulcer and possibly bleeding
A patient will begin taking hydroxychloroquine for rheumatoid arthritis.
The patient is currently taking high-dose NSAIDs and methotrexate.
What should the patient be taught about hydroxychloroquine? Answer:
An eye exam is necessary at the beginning of therapy with this drug
Can cause retinal damage - eye exam at the onset of treatment as well
as every 6 months during treatment
A patient with gout who has increasingly frequent acute gouty attacks
will begin receiving allopurinol and colchicine.
© 2025 All rights reserved
WGU D116 Unit 8 OA Review Questions with Answers
(100% Correct Answers)
A nursing student asks for clarification on the differences between the
mechanisms of spontaneous mutation and conjugation in acquired
resistance of microbes.
Which statement is correct? Answer: Spontaneous mutation leads to
resistance to only one antimicrobial agent
A patient receiving a cephalosporin develops a secondary intestinal
infection caused by Clostridium difficile.
What is an appropriate treatment for this patient? Answer:
Discontinuing the cephalosporin and beginning flagyl
A patient is diagnosed with a lung infection caused by Pseudomonas
aeruginosa. The culture and sensitivity report shows sensitivity to all
aminoglycosides. The provider knows that the rate of resistance to
gentamicin is common in this hospital.
Which medication should the provider be expected to order? Answer:
Amikacin
© 2025 All rights reserved
,2
When resistance to gentamicin and tobramycin is common, amikacin is
the drug of choice for the initial treatment of aminoglycoside-sensitive
infections
A child with otitis media has had three ear infections in the past year.
The child has just completed a ten-day course of amoxicillin with no
improvement. The parent asks the provider why this drug is not
working because it has worked in the past.
What should the provider tell the patient? Answer: "The bacteria have
synthesized penicillinase"
Beta-lactamases are enzymes that cleave the beta-lactam ring and
render the PCN inactive (amoxicillin)
Pt will need to start augmentin
A patient who is taking acetaminophen for pain wants to know why it
does not cause gastrointestinal upset as other over-the-counter pain
medications do.
Which property of acetaminophen is the most likely explanation for
this? Answer: It has minimal effects at peripheral sites
© 2025 All rights reserved
, 3
Tylenol central effects
NSAIDs peripheral effects
A patient who has arthritis has been taking ibuprofen and a
glucocorticoid medication. The patient reports having tarry stools but
denies gastric pain.
Which action by the provider is correct? Answer: Prescribing an
antiulcer medication
Glucocorticoid therapy, especially when combined with NSAIDs, can
increase the risk of gastric ulcer and possibly bleeding
A patient will begin taking hydroxychloroquine for rheumatoid arthritis.
The patient is currently taking high-dose NSAIDs and methotrexate.
What should the patient be taught about hydroxychloroquine? Answer:
An eye exam is necessary at the beginning of therapy with this drug
Can cause retinal damage - eye exam at the onset of treatment as well
as every 6 months during treatment
A patient with gout who has increasingly frequent acute gouty attacks
will begin receiving allopurinol and colchicine.
© 2025 All rights reserved
