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NCA 622 Module 2 - Hypersensitivity Reactions,
Immunology, Transplantation Questions with Answers
(100% Correct Answers)
What is primary immune deficiencies vs secondary? Answer: -Primary -
congenital or inherited (sex-linked, autosomal dominant/recessive)
-Secondary - acquired later in life - AIDS, corticosteroids for
suppression meds, etc
Which types of hypersensitivity reactions are antibody-mediated
reaction, which are cell-mediated? Answer: -Antibody-mediated - Type
I, II, III (immediate)
-Cell-mediated - Type IV (Delayed)
What are the 4 types of Hypersensitivity reactions Answer: ACID:
I - Allergic, Anaphylactic and Atopic (IgE)
II - Cytotoxic (antibody-mediated)(IgG/IgM) - will see hemolysis
III - Immune complex (autoimmune disease) -vasculitis, arthritis, etc
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IV - Delayed (cell-mediated) T-cell
All of the following are associated with type 1 hypersensitivity allergic
reactions EXCEPT:
-hay fever
-angioedema
-serum sickness
-systemic anaphylaxis
-asthma
-eczema
-food and drug allergies
-allergic rhinitis Answer: Serum sickness
What is hay fever? Answer: It is an allergic response usually to outdoor
airborne allergens such as pollen or sometimes indoor allergens such
as dust mites or pet dander also called allergic rhinitis
-Type I hypersensitivity reaction
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What is serum sickness? Answer: allergic rxn 7 days after a new drug
given.
you get immune complexes and fever, urticaria, etc.
-Type III hypersensitivity reaction
-Common causes are vaccines like rabies, immune modulating agents
(rituximab and infliximab) and anti-venoms
-Rash can kind of look like cauliflower
What is number 1 choice of medication for anaphylaxis? Answer:
Epinephrine
When do Type 1 Hypersensitivity Reactions occur? Answer: Usually w/in
15min - 30min of exposure
-Immediate
-Or longer if drug was given orally w food
When do type IV hypersensitivity reactions occur? Answer: Around 72
hours later
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, 4
A 21 y/o male with no PMH presents to the ED with facial swelling,
urticaria, and hives after attending a part where he ate lunch. As the
ACNP, you are concerned with type 1 hypersensitivity reaction and
know that this is due to a:
-IgM mediated reaction
-IgE mediated reaction
-IgG mediated reaction
-Unrelated to any immunoglobulin mediated reaction. Answer: IgE
mediated reaction
As an ACNP whom understands about Type 2 cytotoxic compliment
mediated hypersensitivity reactions, you also know that all of the
following are examples of this type of reaction EXCEPT:
-Rheumatic fever
-ABO blood transfusion reactions
-Steven Johnson's Syndrome (SJS)
-Hemolytic Anemia
© 2025 All rights reserved
NCA 622 Module 2 - Hypersensitivity Reactions,
Immunology, Transplantation Questions with Answers
(100% Correct Answers)
What is primary immune deficiencies vs secondary? Answer: -Primary -
congenital or inherited (sex-linked, autosomal dominant/recessive)
-Secondary - acquired later in life - AIDS, corticosteroids for
suppression meds, etc
Which types of hypersensitivity reactions are antibody-mediated
reaction, which are cell-mediated? Answer: -Antibody-mediated - Type
I, II, III (immediate)
-Cell-mediated - Type IV (Delayed)
What are the 4 types of Hypersensitivity reactions Answer: ACID:
I - Allergic, Anaphylactic and Atopic (IgE)
II - Cytotoxic (antibody-mediated)(IgG/IgM) - will see hemolysis
III - Immune complex (autoimmune disease) -vasculitis, arthritis, etc
© 2025 All rights reserved
,2
IV - Delayed (cell-mediated) T-cell
All of the following are associated with type 1 hypersensitivity allergic
reactions EXCEPT:
-hay fever
-angioedema
-serum sickness
-systemic anaphylaxis
-asthma
-eczema
-food and drug allergies
-allergic rhinitis Answer: Serum sickness
What is hay fever? Answer: It is an allergic response usually to outdoor
airborne allergens such as pollen or sometimes indoor allergens such
as dust mites or pet dander also called allergic rhinitis
-Type I hypersensitivity reaction
© 2025 All rights reserved
,3
What is serum sickness? Answer: allergic rxn 7 days after a new drug
given.
you get immune complexes and fever, urticaria, etc.
-Type III hypersensitivity reaction
-Common causes are vaccines like rabies, immune modulating agents
(rituximab and infliximab) and anti-venoms
-Rash can kind of look like cauliflower
What is number 1 choice of medication for anaphylaxis? Answer:
Epinephrine
When do Type 1 Hypersensitivity Reactions occur? Answer: Usually w/in
15min - 30min of exposure
-Immediate
-Or longer if drug was given orally w food
When do type IV hypersensitivity reactions occur? Answer: Around 72
hours later
© 2025 All rights reserved
, 4
A 21 y/o male with no PMH presents to the ED with facial swelling,
urticaria, and hives after attending a part where he ate lunch. As the
ACNP, you are concerned with type 1 hypersensitivity reaction and
know that this is due to a:
-IgM mediated reaction
-IgE mediated reaction
-IgG mediated reaction
-Unrelated to any immunoglobulin mediated reaction. Answer: IgE
mediated reaction
As an ACNP whom understands about Type 2 cytotoxic compliment
mediated hypersensitivity reactions, you also know that all of the
following are examples of this type of reaction EXCEPT:
-Rheumatic fever
-ABO blood transfusion reactions
-Steven Johnson's Syndrome (SJS)
-Hemolytic Anemia
© 2025 All rights reserved
