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Georgette Q-Bank Domain 1 – PMHNP Board Review | Verified Practice Questions 2025/2026

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Georgette Q-Bank: Domain 1 – PMHNP Board Review (2025/2026) offers a targeted set of verified practice questions with clear, well-explained answers designed to reinforce the foundational competencies tested on the PMHNP certification exam. This question bank focuses on core principles, clinical reasoning, and exam-relevant concepts aligned with Domain 1 content areas. Ideal for candidates preparing for the PMHNP boards, this resource serves as an effective practice tool, study companion, and self-assessment guide to strengthen understanding and improve exam readiness.

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Georgette Q-Bank: Domain 1
Study online at https://quizlet.com/_f7k569

1. *A 42-year-old male patient with a history of bipolar disorder presents to a
psychiatric outpatient clinic. He has been stable on Lithium Carbonate for the
past three ears and has been compliant with his medication regimen. Recently,
he complained of increased thirst and urination, muscle weakness, severe diar-
rhea, and vomiting. The Psychiatric Mental Health Nurse Practitioner (PMHIP)
reviews his recent laboratory results, which shows a serum Lithium level of 1.6.
What is the initial action of the PMHNP?: Discontinue Lithium and Start the patient on an alternative
mood stabilizer.
Correct answer: Discontinuing Lithium and starting the patient on an alternative mood stabilizer is the most appropriate
action in this scenario.
Normal serum lithium level is 0.6-1.2mEq/L
The presence of severe symptoms and a high serum Lithium level of 1.6 suggests severe Lithium toxicity, which can
be life-threatening. Discontinuation of Lithium is crucial to stop further exposure to the toxic effects, and an alternative
mood stabilizer should be initiated to manage the patient's bipolar disorder.
2. *A 26-year-old patient presents to the clinic with a history of recurrent
episodes of depression and anxiety. The patient describes periods of low mood,
fatigue, excessive guilt, and poor concentration. Additionally, the patient ex-
periences episodes of heightened anxiety, restlessness, and racing thoughts.
Based on the patient's presentation, which neurotransmitter systems are most
likely implicated in the pathophysiology of this mood disorder?
A. Serotonin and Norepinephrine
B. Dopamine and GABA
C. Glutamate and Acetylcholine
D. Endorphins and Histamine: **Serotonin and Dopamine
Serotonin and Dopamine Mood disorders, including bipolar disorder, often involve dysregulation of both serotonin and
dopamine systems. Low serotonin levels are associated with depressive symptoms, while elevated dopamine levels are
linked to manic or hypomanic symptoms. The patient's presentation of both depressive and elevated mood episodes
suggests involvement of these two neurotransmitter systems.
3. *A 38-year-old patient with a history of schizophrenia has been taking Olan-
zapine (Zyprexa) for the past year. The patient reports minimal physical activity,
a diet high in processed foods, and a sedentary lifestyle. Recent lab results in-
dicate the development of metabolic syndrome. What is the most appropriate
1/8

, Georgette Q-Bank: Domain 1
Study online at https://quizlet.com/_f7k569

initial action for the psychiatric-mental health nurse practitioner?: ***Educate the
patient on lifestyle modifications, including diet and exercise.
Educate the patient on lifestyle modifications, including diet and exercise. The initial action should be to educate
the patient on lifestyle modifications, including diet and exercise, as these changes can help manage and even
reverse metabolic syndrome. Lifestyle modifications are essential for improving overall health and reducing the risk
of cardiovascular complications.
4. *A 45-year-old patient with bipolar disorder has been taking Quetiapine
(Seroquel) for mood stabilization. The patient leads a sedentary lifestyle and
consumes a high-calorie, low-nutrient diet. Recent assessments reveal the on-
set of metabolic syndrome. What action should the psychiatric-mental health
nurse practitioner (PMHNP) prioritize?

A. Initiate counseling on smoking cessation to address a potential contributing
factor.

B. Prescribe metformin to address insulin resistance and manage weight.

C. Recommend a switch to a different antipsychotic with a lower metabolic
impact.

D. Collaborate with a dietitian to develop a personalized nutrition and exercise
plan.: Correct answer
Collaborate with a dietitian to develop a personalized nutrition and exercise plan.

Rationale: The correct answer is collaborating with a dietitian to develop a personalized nutrition and exercise plan is
essential in addressing the modifiable risk factors associated with metabolic syndrome.
5. You are a PHNP conducting an assessment on a patient who presents with be-
havioral changes, personality disturbances, and language difficulties. Imaging
studies show atrophy in the frontal and temporal lobes. Which of the following
clinical findings is most indicative of possible Pick's disease (frontotemporal
lobar degeneration) in this patient?

A. Gradual and progressive decline in memory and cognitive function over
2/8

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